Announcements Trials
Browse Landscape

Phase

Phase 1 4

Status

Unknown 2Terminated 1Active not recruiting 1

Sponsor Class

OTHER 4

Study Type

Interventional 4

Sponsor

Cancer Type

Sarcoma 9Gynecologic 4Dermatologic 4Gastrointestinal 3Thoracic 2Plasma cell 2Head & Neck 2Genitourinary 2CNS 1Breast 1

Conditions

Melanoma 68Skin Neoplasms 15Neoplasm Metastasis 14Lymphoma, T-Cell, Cutaneous 9Carcinoma, Renal Cell 8Carcinoma, Non-Small-Cell Lung 8Breast Neoplasms 8Neoplasms 7Lymphoma 7Ovarian Neoplasms 6Mycosis Fungoides 6Kidney Neoplasms 6Colorectal Neoplasms 6Carcinoma, Merkel Cell 6Uveal Melanoma 5Uterine Cervical Neoplasms 5Sezary Syndrome 5Multiple Myeloma 5Esophageal Neoplasms 5Carcinoma, Hepatocellular 5Stomach Neoplasms 4Sarcoma, Synovial 4Pancreatic Neoplasms 4Lung Neoplasms 4Head and Neck Neoplasms 4Urinary Bladder Neoplasms 3Triple Negative Breast Neoplasms 3Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 3Neuroblastoma 3Lymphoma, Non-Hodgkin 3

Interventions

Cyclophosphamide 7fludarabine 4pembrolizumab 2fludarabine phosphate 1aldesleukin 1Radiation 1Quality of Life 1Patient Reported Outcome Measures 1Molecular Diagnostic Techniques 1Mass Spectrometry 1Leukapheresis 1Interleukin-2 1Injections 1Immunotherapy, Adoptive 1Immunotherapy 1Imatinib Mesylate 1Drug Therapy 1Decitabine 1Chromatography, High Pressure Liquid 1Biological Therapy 1BI 2536 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Sarcoma, Synovial × fludarabine × Dermatologic × Clear all
NCT02869217 2025-12-03

Study of TBI-1301 (NY-ESO-1 Specific TCR Gene Transduced Autologous T Lymphocytes) in Patients With Solid Tumors

University Health Network, Toronto

Phase 1 Active not recruiting
22 enrolled
DermatologicGastrointestinalGenitourinaryGynecologicSarcomaThoracic

Urinary Bladder Neoplasms, Esophageal Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Ovarian Neoplasms, Sarcoma, Synovial

NCT03399448 2023-06-22

NY-ESO-1-redirected CRISPR (TCRendo and PD1) Edited T Cells (NYCE T Cells)

University of Pennsylvania

Phase 1 Terminated
3 enrolled
DermatologicPlasma cellSarcoma

Melanoma, Multiple Myeloma, Sarcoma, Synovial, Liposarcoma, Myxoid

NCT02366546 2018-10-24

Investigator Initiated Phase 1 Study of TBI-1301

Mie University

Phase 1 Unknown
9 enrolled
DermatologicGastrointestinalGynecologicHead & NeckSarcoma

Esophageal Neoplasms, Head and Neck Neoplasms, Melanoma, Ovarian Neoplasms, Sarcoma, Synovial

NCT02457650 2016-08-03

T Cell Receptor-transduced T Cells Targeting NY-ESO-1 for Treatment of Patients With NY-ESO-1- Expressing Malignancies

Shenzhen Second People's Hospital

Phase 1 Unknown
36 enrolled
BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicPlasma cellSarcomaThoracic

Urinary Bladder Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Lung Neoplasms, Melanoma, Multiple Myeloma, Neuroblastoma, Ovarian Neoplasms, Sarcoma, Synovial

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