Clinical Trials

Neoplasm Metastasis, Skin Neoplasms, Carcinoma, Merkel Cell

NCT06362369 2026-04-13

A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab Monotherapy

DermatologicGastrointestinalGenitourinaryOther solid neoplasmThoracic

126 enrolled

Turcot syndrome, Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Kidney Neoplasms, Liver Neoplasms, Melanoma, Neoplasm Metastasis, Skin Neoplasms, Colorectal Neoplasms

NCT06585410 2026-04-08

Study of Intralesional Cemiplimab in Adult Patients With Early Stage Cutaneous Squamous Cell Carcinoma

Phase 3 Recruiting

369 enrolled

Skin Neoplasms

NCT05047094 2026-04-06

Alpha Radiation Emitters Device (DaRT) in Combination With Check Point Inhibitor for the Treatment of Recurrent Unresectable or mHNSCC

48 enrolled

DermatologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Recurrence, Skin Neoplasms

NCT05727904 2026-04-03

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

Phase 3 Recruiting

670 enrolled

Melanoma, Skin Neoplasms

NCT07510061 2026-04-03

ICARUS

80 enrolled

Hyperthermia, Skin Neoplasms, Heat Stress Disorders, Cognitive Dysfunction

NCT02621021 2026-04-01

A Phase 2 Trial for Metastatic Melanoma Using Adoptive Cell Therapy With Tumor Infiltrating Lymphocytes Plus IL-2 Either Alone or Following the Administration of Pembrolizumab

170 enrolled

Melanoma, Skin Neoplasms

NCT04562129 2026-04-01

IL2 With Ipilimumab Followed by Nivolumab in Stage 3 or 4 Melanoma Patients

29 enrolled

Melanoma, Skin Neoplasms

NCT05070403 2026-04-01

Study of Afatinib in Advanced Cutaneous Squamous Cell Carcinoma

25 enrolled

Phase EARLY_PHASE1 Recruiting

Carcinoma, Squamous Cell, Skin Neoplasms

NCT05651828 2026-04-01

Adaptive Therapy of Vismodegib in Advanced Basal Cell Carcinoma

34 enrolled

Skin Neoplasms

NCT06298734 2026-04-01

High-Intensity Exercise and High-Fiber Diet for Immunotherapy Outcomes in Melanoma Patients: The DUO Trial

40 enrolled

Melanoma, Skin Neoplasms

NCT06875609 2026-03-30

ctDNA in Cutaneous Squamous Cell Carcinoma

60 enrolled

Skin Neoplasms, Neoplasm, Residual

NCT06060613 2026-03-27

Agni-01

208 enrolled

DermatologicThoracic

Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Melanoma, Skin Neoplasms

NCT07349940 2026-03-27

MEL

1,440 enrolled

Phase EARLY_PHASE1 Recruiting

Melanoma, Nevus, Skin Neoplasms

NCT05702398 2026-03-20

Pilot Trial of Supplemental Vitamin A and Nicotinamide

30 enrolled

Skin Neoplasms

NCT06926075 2026-03-17

ADVICE

BreastCNSDermatologicGastrointestinalGenitourinaryGynecologicThoracic

80 enrolled

Breast Neoplasms, Glioblastoma, Lung Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Skin Neoplasms

NCT06349642 2026-03-12

ELEPHAS-04

DermatologicGastrointestinalGenitourinaryGynecologicSarcomaThoracic

324 enrolled

Clear-cell metastatic renal cell carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinosarcoma, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Neoplasm Metastasis, Skin Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT06981325 2026-03-11

CEMI-first

34 enrolled

Carcinoma, Basal Cell, Skin Neoplasms

NCT00040352 2026-03-09

Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Melanoma

3,000 enrolled

Dysplastic Nevus Syndrome, Melanoma, Skin Neoplasms

NCT06171750 2026-03-06

ANCHOR

Phase 1 Recruiting

97 enrolled

DermatologicThoracic

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Skin Neoplasms

NCT04349436 2026-02-27

ARTACUS

90 enrolled

Carcinoma, Carcinoma, Basal Cell, Neoplasms, Skin Neoplasms, Carcinoma, Merkel Cell

NCT04354064 2026-02-20

Circulating Tumor DNA (ctDNA) for Early Treatment Response Assessment of Solid Tumors

BreastDermatologicGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Prostatic Neoplasms, Sarcoma, Skin Neoplasms, Urogenital Neoplasms

NCT07042243 2026-02-20

The Florida ASCENT Study

BreastDermatologicGastrointestinalGenitourinaryOther hematologic neoplasmThoracic

Breast Neoplasms, Feeding Behavior, Food Preferences, Lung Neoplasms, Melanoma, Neoplasms, Prostatic Neoplasms, Skin Neoplasms, Colorectal Neoplasms, Hematologic Neoplasms, Malnutrition

NCT07422779 2026-02-20

MAK

Melanoma, Skin Neoplasms

NCT07404605 2026-02-19

Electrochemotherapy-Induced Changes in Tumor Microenvironment in Cutaneous Melanoma

150 enrolled

Melanoma, Skin Neoplasms

NCT07288073 2026-02-13

TIL Therapy in cSCC and MCC

14 enrolled

Skin Neoplasms, Carcinoma, Merkel Cell

NCT06675643 2026-02-10

Digital Remote Monitoring of Immune Checkpoint Inhibitor Therapy Induced Toxicity Using the Vigilant App

Melanoma, Skin Neoplasms

NCT07222995 2026-02-05

Hybrid Effectiveness-Implementation Trial to Integrate Precision Skin Cancer Risk Feedback in FQHCs

2,900 enrolled

Skin Neoplasms

NCT07138222 2026-01-28

IMPACT

80 enrolled

Inflammation, Melanoma, Skin Neoplasms

NCT02012699 2026-01-22

iCaRe2

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckNETOther hematologic neoplasmOther solid neoplasmPlasma cellSarcomaThoracic

999,999 enrolled

Anus Neoplasms, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Breast Neoplasms, Colonic Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Duodenal Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Hypopharyngeal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Lip Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Mesothelioma, Mouth Neoplasms, Multiple Myeloma, Nasopharyngeal Neoplasms, Neoplasms, Unknown Primary, Oropharyngeal Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Paranasal Sinus Neoplasms, Paraproteinemias, Penile Neoplasms, Peritoneal Neoplasms, Adenomatous Polyposis Coli, Prostatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Sarcoma, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Ureteral Neoplasms, Urethral Neoplasms, Vaginal Neoplasms, Central Nervous System Neoplasms, Thyroid Nodule, Endometrial Neoplasms, Neuroendocrine Tumors, Gastrointestinal Stromal Tumors

NCT06932172 2026-01-12

AI-DSSC

3,000 enrolled

Skin Neoplasms

NCT07288203 2026-01-12

A Study of Lifileucel (Tumor-infiltrating Lymphocytes) in Adults With Advanced Melanoma

Melanoma, Skin Neoplasms

NCT07327489 2026-01-08

ELEPHAS-05

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

2,000 enrolled

Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Kidney Neoplasms, Liver Neoplasms, Melanoma, Neoplasms, Skin Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT05779423 2026-01-06

Cryoablation+Ipilimumab+Nivolumab in Melanoma

37 enrolled

Melanoma, Skin Neoplasms

NCT05520099 2025-12-26

ELEPHAS-02

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

416 enrolled

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Neoplasms, Skin Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms

NCT06022029 2025-12-24

ON-5001

Phase 1 Recruiting

168 enrolled

BreastDermatologicGenitourinaryGynecologicHead & NeckLymphoid

Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Bites and Stings, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma in Situ, Uterine Cervical Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Melanoma, Neoplasm Metastasis, Neoplasms, Recurrence, Skin Neoplasms, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell, Triple Negative Breast Neoplasms

NCT07251335 2025-12-18

Mesur

300 enrolled

Melanoma, Occupational Diseases, Skin Neoplasms

NCT06608511 2025-12-17

Liquid Biomarker Study in Melanoma and Non-Melanoma Skin Cancers

20 enrolled

Carcinoma, Basal Cell, Melanoma, Skin Neoplasms

NCT05389332 2025-12-16

A Mobile Health Intervention Among Hispanics

114 enrolled

Skin Neoplasms

NCT07213154 2025-12-16

Optical Imaging Scans for the Diagnosis of Skin Cancer in Patients With Lesions

10 enrolled

Skin Diseases, Skin Neoplasms

NCT07200544 2025-12-15

Meloxicam in Mohs Micrographic Surgery

Phase 4 Recruiting

300 enrolled

Pain, Postoperative, Skin Neoplasms

NCT07266142 2025-12-12

Prospective Collection of Clinical Data and Human Body Material (HBM) of Cutaneous Melanoma and Non Melanoma Patients. Biobank Huidkanker

7,500 enrolled

Melanoma, Skin Neoplasms

NCT07062003 2025-12-09

Minibeam Radiation Therapy With Tungsten Slit Collimator for the Treatment of Recurrent or Metastatic Skin or Soft Tissue Tumors, MBRT1 Trial

60 enrolled

DermatologicSarcoma

Sarcoma, Skin Neoplasms, Soft Tissue Neoplasms

NCT04996823 2025-12-04

Axitinib + Ipilimumab in Advanced Melanoma

25 enrolled

DermatologicHead & NeckSarcoma

Melanoma, Skin Neoplasms

NCT05859074 2025-12-03

A Study of MQ710 With and Without Pembrolizumab in People With Solid Tumor Cancer

Phase 1 Recruiting

56 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Hemangiosarcoma, Melanoma, Neoplasm Metastasis, Neoplasms, Paget Disease, Extramammary, Sarcoma, Kaposi, Skin Neoplasms, Carcinoma, Merkel Cell, Adenocarcinoma, Sebaceous, Carcinoma, Skin Appendage

NCT03889899 2025-12-02

Alpha Radiation Emitters Device (DaRT) for the Treatment of Cutaneous, Mucosal or Superficial Soft Tissue Neoplasia.

DermatologicHead & NeckSarcoma

30 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Lip Neoplasms, Sarcoma, Kaposi, Skin Neoplasms, Soft Tissue Neoplasms, Tongue Neoplasms

NCT05323253 2025-12-02

A Clinical Study to Assess the Efficacy and Safety of Alpha DaRT224 for the Treatment of Patients With Recurrent Cutaneous Squamous Cell Carcinoma

86 enrolled

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckOther hematologic neoplasmThoracic

Carcinoma, Squamous Cell, Skin Neoplasms

NCT05786716 2025-12-02

DETERMINE

Phase 2/3 Recruiting

30 enrolled

Urinary Bladder Neoplasms, Gallbladder Neoplasms, Lung Neoplasms, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Skin Neoplasms, Colorectal Neoplasms, Hematologic Neoplasms

NCT03452774 2025-10-28

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidMyeloidNETOther hematologic neoplasmThoracic

50,000 enrolled

Turcot syndrome, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Glioblastoma, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Kidney Neoplasms, Laryngeal Neoplasms, Leukemia, Liver Neoplasms, Lung Neoplasms, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Melanoma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Skin Neoplasms, Stomach Neoplasms, Testicular Neoplasms, Central Nervous System Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma, Neuroendocrine Tumors, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Primary Myelofibrosis

NCT06664151 2025-10-02

A Phase 0 Window of Opportunity Trial of Intratumoral Seasonal Influenza Immunization in Cutaneous Squamous Cell Carcinoma (CSCC) Patients Awaiting Curative Excision

Phase EARLY_PHASE1 Recruiting

25 enrolled