Announcements Trials
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Phase

Phase 3 2Phase 1 2

Status

Completed 3Active not recruiting 1

Sponsor Class

NIH 2INDUSTRY 2

Study Type

Interventional 4

Sponsor

Cancer Type

Dermatologic 4Gastrointestinal 3Sarcoma 2Tumor-Agnostic 1Head & Neck 1

Conditions

Melanoma 3Squamous Cell Carcinoma of Head and Neck 1Skin Neoplasms 1Sarcoma, Kaposi 1HIV Infections 1Acquired Immunodeficiency Syndrome 1

Interventions

pembrolizumab 339Nivolumab 305Ipilimumab 274Cyclophosphamide 195aldesleukin 148Interleukin-2 110fludarabine phosphate 107trametinib 85Temozolomide 83fludarabine 81Dacarbazine 81dabrafenib 77Radiotherapy 75Biopsy 75Vemurafenib 71Imiquimod 53Bevacizumab 51sargramostim 50Magnetic Resonance Spectroscopy 50Specimen Handling 49Radiosurgery 49Peripheral Blood Stem Cell Transplantation 49Paclitaxel 49Aminolevulinic Acid 49binimetinib 48Carboplatin 48Blood Specimen Collection 47cemiplimab 46Cisplatin 453-ingenyl angelate 45

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Tumor Necrosis Factor-alpha × Dermatologic × Clear all
NCT05222932 2025-08-07

AVENTIL

TILT Biotherapeutics Ltd.

Phase 1 Active not recruiting
15 enrolled
DermatologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Melanoma

NCT00003789 2013-07-16

Melphalan With or Without Tumor Necrosis Factor in Treating Patients With Locally Advanced Melanoma of the Arm or Leg

National Cancer Institute (NCI)

Phase 3 Completed
216 enrolled
Dermatologic

Melanoma

NCT00001296 2008-03-04

A Randomized Phase III Trial of Hyperthermic Isolated Limb Perfusion With Melphalan, Tumor Necrosis Factor, and Interferon-Gamma in Patients With Locally Advanced Extremity Melanoma

National Institutes of Health Clinical Center (CC)

Phase 3 Completed
122 enrolled
Dermatologic

Melanoma

NCT00002262 2005-06-24

A Phase I/II Study of Intralesional Recombinant Tumor Necrosis Factor in Patients With AIDS-Related Cutaneous Kaposi's Sarcoma

NIH AIDS Clinical Trials Information Service

Phase 1 Completed
DermatologicSarcoma

Acquired Immunodeficiency Syndrome, Sarcoma, Kaposi, Skin Neoplasms, HIV Infections

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