Announcements Trials
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Phase

Phase 3 2Phase 1 2

Status

Completed 3Active not recruiting 1

Sponsor Class

NIH 2INDUSTRY 2

Study Type

Interventional 4

Sponsor

Cancer Type

Dermatologic 4Gastrointestinal 3Sarcoma 2Head & Neck 1

Conditions

Melanoma 3Squamous Cell Carcinoma of Head and Neck 1Skin Neoplasms 1Sarcoma, Kaposi 1HIV Infections 1Acquired Immunodeficiency Syndrome 1

Interventions

pembrolizumab 326Nivolumab 289Ipilimumab 260Cyclophosphamide 194aldesleukin 145Interleukin-2 109fludarabine phosphate 107Temozolomide 83fludarabine 81Dacarbazine 81Radiotherapy 74trametinib 73Vemurafenib 69dabrafenib 66Biopsy 65sargramostim 50Bevacizumab 50Radiosurgery 49Paclitaxel 49Peripheral Blood Stem Cell Transplantation 48Magnetic Resonance Spectroscopy 48Carboplatin 48Imiquimod 47Aminolevulinic Acid 47binimetinib 45Cisplatin 45CTLA-4 Antigen 43cemiplimab 42Specimen Handling 42atezolizumab 41

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Interventional × Tumor Necrosis Factor-alpha × Dermatologic × Clear all
NCT05222932 2025-08-07

AVENTIL

TILT Biotherapeutics Ltd.

Phase 1 Active not recruiting
15 enrolled
DermatologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Melanoma

NCT00003789 2013-07-16

Melphalan With or Without Tumor Necrosis Factor in Treating Patients With Locally Advanced Melanoma of the Arm or Leg

National Cancer Institute (NCI)

Phase 3 Completed
216 enrolled
Dermatologic

Melanoma

NCT00001296 2008-03-04

A Randomized Phase III Trial of Hyperthermic Isolated Limb Perfusion With Melphalan, Tumor Necrosis Factor, and Interferon-Gamma in Patients With Locally Advanced Extremity Melanoma

National Institutes of Health Clinical Center (CC)

Phase 3 Completed
122 enrolled
Dermatologic

Melanoma

NCT00002262 2005-06-24

A Phase I/II Study of Intralesional Recombinant Tumor Necrosis Factor in Patients With AIDS-Related Cutaneous Kaposi's Sarcoma

NIH AIDS Clinical Trials Information Service

Phase 1 Completed
DermatologicSarcoma

Acquired Immunodeficiency Syndrome, Sarcoma, Kaposi, Skin Neoplasms, HIV Infections

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