Announcements Trials
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Phase

Phase 1/2 1Phase 1 1

Status

Terminated 1Completed 1

Sponsor Class

NIH 2

Study Type

Interventional 2

Sponsor

Cancer Type

Thoracic 3Other solid neoplasm 3Gastrointestinal 2

Conditions

Mesothelioma, Malignant 2Lung Neoplasms 2Esophageal Neoplasms 2Colorectal Neoplasms 2Carcinoma, Non-Small-Cell Lung 2Small Cell Lung Carcinoma 1Pleural Effusion, Malignant 1Pancreatic Neoplasms 1Pancreatic Adenocarcinoma Metastatic 1Neoplasms 1Neoplasm Metastasis 1Metastatic Pancreatic Adenocarcinoma 1Esophageal Squamous Cell Carcinoma 1Colorectal Cancer Metastatic 1Colonic Neoplasms 1

Interventions

Cyclophosphamide 4pembrolizumab 3Nivolumab 3regorafenib 2fludarabine 2SS1(dsFv)PE38 2Ipilimumab 2Hyperthermic Intraperitoneal Chemotherapy 2Doxorubicin 2Decitabine 2Cisplatin 2tislelizumab 1sodium thiosulfate 1sargramostim 1entinostat 1durvalumab 1cemiplimab 1bemcentinib 1avelumab 1atezolizumab 1alvocidib 1alanosine 1X-Rays 1Tetrahydrouridine 1Tamoxifen 1Surveys and Questionnaires 1Surgical Procedures, Operative 1Specimen Handling 1Referral and Consultation 1Radiotherapy 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Mesothelioma, Malignant × Decitabine × Gastrointestinal × Clear all
NCT03233724 2023-05-31

Oral Decitabine and Tetrahydrouridine as Epigenetic Priming for Pembrolizumab-Mediated Immune Checkpoint Blockade in Patients With Inoperable, or Unresectable Locally Advanced or Metastatic Non-Small Cell Lung Cancers and Esophageal Carcinomas

National Institutes of Health Clinical Center (CC)

Phase 1/2 Terminated
9 enrolled 14 charts
GastrointestinalOther solid neoplasmThoracic

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Lung Neoplasms

NCT00019825 2015-04-29

Decitabine in Treating Patients With Unresectable Lung or Esophageal Cancer or Malignant Mesothelioma of the Pleura

National Cancer Institute (NCI)

Phase 1 Completed
GastrointestinalOther solid neoplasmThoracic

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Pleural Effusion, Malignant, Small Cell Lung Carcinoma

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