Clinical Trials

780 enrolled

Postoperative Complications, Stomach Neoplasms, Microsatellite Instability

NCT06004245 2026-05-08

A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors

Phase 1 Recruiting

280 enrolled

Colorectal Neoplasms, Microsatellite Instability

NCT06428487 2026-04-27

Neoadjuvant Prolgolimab Monotherapy in Locally Advanced MMR-deficient Colorectal Cancer

Phase 2 Completed

Colorectal Neoplasms, Microsatellite Instability

NCT03519412 2026-03-03

ARETHUSA

Phase 2 Completed

107 enrolled 14 charts

GastrointestinalGynecologic

Colorectal Neoplasms, Microsatellite Instability

NCT06625515 2026-02-24

First-in-Human Study of ATX-559, an Oral Inhibitor of DHX9, in Patients With Advanced or Metastatic Solid Tumors, and Molecularly Defined Cancers

Phase 1 Terminated

17 enrolled

Colonic Neoplasms, Rectal Neoplasms, Endometrial Neoplasms, Microsatellite Instability

NCT03228667 2026-01-14

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

40 enrolled

Turcot syndrome, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Carcinoma, Hepatocellular, Melanoma, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Microsatellite Instability, Small Cell Lung Carcinoma

NCT02628067 2025-09-22

KEYNOTE 158

EndocrineGastrointestinalGynecologicHead & NeckNETOther solid neoplasmThoracic

1,609 enrolled 4 FDA

Parkinson Disease 4, Autosomal Dominant Lewy Body, Anus Neoplasms, Bile Duct Neoplasms, Biliary Tract Neoplasms, Carcinoid Tumor, Uterine Cervical Neoplasms, Mesothelioma, Parotid Neoplasms, Salivary Gland Neoplasms, Thyroid Neoplasms, Vulvar Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Cholangiocarcinoma, Neuroendocrine Tumors, Microsatellite Instability, Small Cell Lung Carcinoma

NCT05511688 2025-09-02

National Cohort of Colorectal Cancers With Microsatellite Instability

Active not recruiting

637 enrolled

Colorectal Neoplasms, Microsatellite Instability

NCT03350126 2025-07-23

NIPICOL

57 enrolled

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Colonic Neoplasms, Microsatellite Instability

NCT05592626 2025-07-09

START-001

Phase 1/2 Recruiting

365 enrolled

Abdominal Neoplasms, Biliary Tract Neoplasms, Urinary Bladder Neoplasms, Carcinoma, Carcinoma, Basal Cell, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Genital Neoplasms, Female, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Nasopharyngeal Neoplasms, Neoplasms, Neoplasms by Site, Stomach Neoplasms, Urogenital Neoplasms, Vulvar Diseases, Vulvar Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Endometrial Neoplasms, Epstein-Barr Virus Infections, Papillomavirus Infections, Microsatellite Instability, Small Cell Lung Carcinoma

NCT06414304 2025-06-27

BLOOMSI

Phase 2 Not yet recruiting

Colonic Neoplasms, Neoplasms, Colorectal Neoplasms, Microsatellite Instability

NCT06646445 2025-06-13

PREMICES

60 enrolled

Turcot syndrome, Colonic Neoplasms, Microsatellite Instability

NCT04817826 2025-06-10

INFINITY

31 enrolled

Stomach Neoplasms, Microsatellite Instability

NCT05257057 2025-03-28

Frequency of Endometrial Cancer Precursors Associated with Lynch Syndrome

GastrointestinalGynecologic

91 enrolled

Turcot syndrome, Colorectal Neoplasms, Hereditary Nonpolyposis, Endometrial Hyperplasia, Endometrial Neoplasms, Microsatellite Instability

NCT03436563 2024-11-27

M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instability

Phase 1/2 Completed

4 enrolled 7 charts

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms, Microsatellite Instability

NCT03594448 2024-08-29

Detection of MSI in Circulating Tumor DNA of Colorectal Carcinoma Patients

Terminated

6 enrolled

Colorectal Neoplasms, Microsatellite Instability

NCT05177133 2024-08-02

AuspiCiOus

Phase 2 Recruiting

25 enrolled

Adenocarcinoma Of Esophagus, Microsatellite Instability

NCT06238193 2024-02-02

Molecular Characteristics of Early-onset Compared With Late-onset Colorectal Cancer

11,344 enrolled

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidThoracic

Colorectal Neoplasms, Microsatellite Instability

NCT04106167 2023-09-21

Long-term, Non-interventional, Observational Study Following Treatment With Fate Therapeutics FT500 Cellular Immunotherapy

Terminated

20 enrolled

Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Lymphoma, Melanoma, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Microsatellite Instability, Small Cell Lung Carcinoma

NCT03841110 2023-05-01

FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumors

Phase 1 Completed

37 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidThoracic

Breast Neoplasms, Carcinoma, Renal Cell, Carcinoma, Squamous Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Lymphoma, Melanoma, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Microsatellite Instability, Small Cell Lung Carcinoma

NCT03827044 2022-10-07

POLEM

Phase 3 Terminated

Colonic Neoplasms, Microsatellite Instability

NCT03485196 2022-08-10

The Relationship Between Microsatellite Instability and Efficacy of Fluorouracil Based Adjuvant Chemotherapy in Gastric Cancer After Operation

1,000 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidThoracic

Stomach Neoplasms, Microsatellite Instability

NCT02178722 2022-02-14

Study to Explore the Safety, Tolerability and Efficacy of MK-3475 in Combination With INCB024360 in Participants With Selected Cancers

Phase 1/2 Completed

444 enrolled 19 charts

Urinary Bladder Neoplasms, Carcinoma, Renal Cell, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Lung Neoplasms, Lymphoma, Melanoma, Ovarian Neoplasms, Stomach Neoplasms, Endometrial Neoplasms, Microsatellite Instability, Triple Negative Breast Neoplasms

NCT05162248 2021-12-17

MSI-CRC

231 enrolled

Colorectal Neoplasms, Microsatellite Instability

NCT03047226 2021-07-15

Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Colorectal Cancer

311 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidOther solid neoplasmThoracic

Colorectal Neoplasms, Hereditary Nonpolyposis, Microsatellite Instability

NCT03538028 2020-10-30

A Safety and Tolerability Study of INCAGN02385 in Select Advanced Malignancies

Phase 1 Completed

22 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Transitional Cell, Uterine Cervical Neoplasms, Esophageal Neoplasms, Carcinoma, Hepatocellular, Melanoma, Mesothelioma, Neoplasm Metastasis, Ovarian Neoplasms, Recurrence, Stomach Neoplasms, Carcinoma, Merkel Cell, Lymphoma, Large B-Cell, Diffuse, Microsatellite Instability, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT03447431 2019-07-02

Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact

350 enrolled

Colorectal Neoplasms, Microsatellite Instability

NCT03774862 2018-12-13

Clinicopathological Importance of Colorectal Medullary Carcinoma: Retrospective Cohort Study

13 enrolled

Colorectal Neoplasms, Carcinoma, Medullary, Microsatellite Instability

NCT03744962 2018-11-19

MSI in Circulatory DNA of Endometrial Cancer

GastrointestinalGynecologic

100 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Neoplastic Cells, Circulating, Endometrial Neoplasms, Microsatellite Instability

NCT03561350 2018-06-19

Detect Microsatellite Instability Status in Blood Sample of Advanced Colorectal Cancer Patients by Next-Generation Sequencing

60 enrolled

Colorectal Neoplasms, Microsatellite Instability

NCT00952874 2010-06-25

Molecular Biology of Anal Cancer in HIV-Positive Patients

Anus Neoplasms, Carcinoma, HIV Infections, Papillomavirus Infections, Microsatellite Instability

NCT00141466 2008-04-23

Implementation of a New Strategy to Identify HNPCC Patients

Phase NA Unknown

360 enrolled

Colorectal Neoplasms, Hereditary Nonpolyposis, Colorectal Neoplasms, Microsatellite Instability

NCT00220246 2007-03-01

Clinical and Molecular Characterization of Familial Microsatellite Stable Colorectal Cancer

130 enrolled

Colorectal Neoplasms, Chromosomal Instability, Microsatellite Instability

NCT00172757 2005-11-28

Association of Colorectal Cancer With Nutrition, Diet, Obesity, Diabetes Mellitus, and Genetic Alterations in Taiwan

1,000 enrolled

Colorectal Neoplasms, Microsatellite Instability

NCT00173472 2005-11-24

Association of MSI, TS, DPD, MVD and EGFR With Chemosensitivity in Stage IV in Colorectal Cancer

200 enrolled