Clinical Trials

Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasm Metastasis, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT05665348 2026-03-09

TRIPLET

Phase 2/3 Completed

229 enrolled

Carcinoma, Hepatocellular, Neoplasm Metastasis

NCT07407465 2026-02-17

CHIMERA

Phase 2 Recruiting

42 enrolled

Phase 1 Active not recruiting

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT04449874 2026-02-12

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation

498 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Neoplasm Metastasis, Colorectal Neoplasms

NCT06268015 2026-02-05

BBOpCo

Phase 2 Active not recruiting

16 enrolled

Neoplasm Metastasis, Colorectal Neoplasms

NCT06792695 2026-01-20

CANTOR

Phase 2 Recruiting

120 enrolled

Neoplasm Metastasis, Colorectal Neoplasms

NCT05678257 2025-09-12

A Study of NUC-3373 in Combination With Other Agents in Patients With Colorectal Cancer

180 enrolled 16 charts

Phase 3 Not yet recruiting

Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT06680258 2025-09-03

A Study of TPST-1120 With Atezolizumab Plus Bevacizumab in Patients With Unresectable or Metastatic HCC Not Previously Treated With Systemic Therapy

740 enrolled

Carcinoma, Hepatocellular, Liver Neoplasms, Neoplasm Metastasis

NCT02885753 2025-07-09

OSCAR

Phase 3 Recruiting

348 enrolled

GastrointestinalLymphoidOther hematologic neoplasmSarcoma

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT04553692 2025-03-28

Phase 1a/1b Study of Aplitabart (IGM-8444) Alone or in Combination in Participants with Relapsed, Refractory, or Newly Diagnosed Cancers

Phase 1 Terminated

272 enrolled

Chondrosarcoma, Lymphoma, Non-Hodgkin, Neoplasm Metastasis, Sarcoma, Colorectal Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Acute

NCT05087992 2025-02-19

A Study to Find the Best Dose of BI 905711 in Combination With Chemotherapy and to Test Whether This Dose Helps People With Advanced Gastrointestinal Cancers

13 enrolled 17 charts

DermatologicGastrointestinalGenitourinarySarcoma

Gastrointestinal Neoplasms, Neoplasm Metastasis

NCT05824975 2024-11-25

A Study to Evaluate the Safety and Therapeutic Activity of GI-102 As a Single Agent and in Combination with Conventional Anti-cancer Drugs, Pembrolizumab or Trastuzumab Deruxtecan(T-DXd) in Patients with Advanced Solid Tumors (KEYNOTE-G08)

Phase 1/2 Recruiting

358 enrolled

Diabetes Mellitus, Insulin-Dependent, 12, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Melanoma, Neoplasm Metastasis, Sarcoma, Colorectal Neoplasms

NCT06448364 2024-11-06

LTbR

Phase 1 Terminated

4 enrolled

DermatologicGastrointestinalGenitourinaryThoracic

Non-Muscle Invasive Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Melanoma, Neoplasm Metastasis, Colorectal Neoplasms

NCT04999761 2024-09-25

AB122 Platform Study

Phase 1 Recruiting

917 enrolled

GastrointestinalHead & NeckSarcomaThoracic

Biliary Tract Neoplasms, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Head and Neck Neoplasms, Neoplasm Metastasis, Stomach Neoplasms, Colorectal Neoplasms, Sarcoma, Alveolar Soft Part

NCT03475004 2024-09-19

Study of Pembrolizumab, Binimetinib, and Bevacizumab in Patients With Refractory Colorectal Cancer

53 enrolled 14 charts

Neoplasm Metastasis, Colorectal Neoplasms

NCT02743221 2024-08-20

TASCO1

154 enrolled 15 charts

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT02848443 2024-07-25

Study of S 95005 in Combination With Oxaliplatin in Metastatic Colorectal Cancer

78 enrolled

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT02842580 2024-07-10

HIGH-LIGHT

21 enrolled 12 charts

BreastClassical hematologyGastrointestinalGenitourinaryLymphoidMyeloidOther hematologic neoplasmPlasma cell

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT03878524 2024-03-04

Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

Phase 1 Terminated

2 enrolled

Anemia, Blast Crisis, Breast Neoplasms, Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma, Myelodysplastic Syndromes, Myeloproliferative Disorders, Neoplasm Metastasis, Pancreatic Neoplasms, Prostatic Neoplasms, Thrombocytosis, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Accelerated Phase, Leukemia, Myeloid, Chronic-Phase, Leukemia, Myeloid, Acute, Leukemia, Myelomonocytic, Chronic, Hematologic Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Myelodysplastic-Myeloproliferative Diseases, Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative, Primary Myelofibrosis

NCT03698461 2024-01-31

CLIMB

20 enrolled

Phase 2 Not yet recruiting

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT06192680 2024-01-18

Liposomal Irinotecan and Capecitabine Plus Bevacizumab as Second-line Therapy in Metastatic Colorectal Cancer

63 enrolled

Neoplasm Metastasis, Colorectal Neoplasms

NCT01718873 2023-04-12

OBELICS

230 enrolled 12 charts

Neoplasm Metastasis, Colorectal Neoplasms

NCT00819780 2022-12-06

PEAK: Panitumumab Plus mFOLFOX6 vs. Bevacizumab Plus mFOLFOX6 for First Line Treatment of Metastatic Colorectal Cancer (mCRC) Patients With Wild-Type Kirsten Rat Sarcoma-2 Virus (KRAS) Tumors

285 enrolled 31 charts

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT01759238 2022-07-01

OLGA

1 enrolled

Neoplasm Metastasis, Colorectal Neoplasms

NCT00321100 2022-01-12

Combination of Cetuximab, Capecitabine, and Oxaliplatin With or Without Bevacizumab

23 enrolled 8 charts

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT01442649 2022-01-11

Efficacy of Chemotherapy, Associated to Either Cetuximab or Bevacizumab, in KRAS Wild-type Metastatic Colorectal Cancer Patients With Progressive Disease After Receiving First-line Treatment With Bevacizumab

133 enrolled

Adenocarcinoma, Neoplasm Metastasis, Colorectal Neoplasms

NCT02015923 2021-03-16

CCRe-IV

Phase 4 Terminated

107 enrolled

Colonic Neoplasms, Neoplasm Metastasis

NCT01327612 2021-02-21

Open Label Extension Study of Conatumumab and Ganitumab (AMG 479)

EndocrineGastrointestinalLymphoidSarcomaThoracic

12 enrolled 21 charts

Carcinoid Tumor, Carcinoma, Non-Small-Cell Lung, Lymphoma, Neoplasm Metastasis, Sarcoma, Colorectal Neoplasms

NCT01858649 2020-10-22

BEV-ONCO2012

60 enrolled

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT02226289 2020-09-02

BATTLE

Phase 2 Unknown

46 enrolled

Neoplasm Metastasis, Neoplasms, Colorectal Neoplasms

NCT04380103 2020-05-08

A Phase I/II Study of XELOXIRI and Bevacizumab as First-line Treatment in Metastatic Colorectal Cancer

Phase 1/2 Unknown

106 enrolled

Neoplasm Metastasis, Colorectal Neoplasms

NCT02069704 2019-07-23

Bioequivalence Study Bevacizumab Biosimilar (BEVZ92) Versus Bevacizumab (AVASTIN®) in First-line Treatment mCRC Patients

142 enrolled 28 charts

Neoplasm Metastasis, Colorectal Neoplasms

NCT01206530 2019-04-18

FOLFOX/Bevacizumab/Hydroxychloroquine (HCQ) in Colorectal Cancer

Phase 1/2 Completed

50 enrolled

Adenocarcinoma, Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms

NCT00483834 2019-02-15

A Phase II Study of Bevacizumab, Irinotecan and Capecitabine in Patients With Previously Untreated Metastatic Colorectal Cancer

50 enrolled

Neoplasm Metastasis, Colorectal Neoplasms

NCT01996306 2019-01-08

AXEPT

650 enrolled

Digestive System Neoplasms, Gastrointestinal Neoplasms, Intestinal Neoplasms, Neoplasm Metastasis, Colorectal Neoplasms

NCT00418938 2018-10-17

SPIRITT - Second-Line Panitumumab Irinotecan Treatment Trial

266 enrolled 17 charts

Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Rectal Neoplasms, Colorectal Neoplasms

NCT01918852 2018-03-14

SALTO

161 enrolled

Neoplasm Metastasis, Colorectal Neoplasms, Hand-Foot Syndrome

NCT03303495 2017-10-06

A Study of 2nd-line FOLFIRI ± Bevacizumab vs. Irinotecan ± Bevacizumab in mCRC

Phase 3 Unknown

280 enrolled

Digestive System Neoplasms, Gastrointestinal Neoplasms, Intestinal Neoplasms, Neoplasm Metastasis, Colorectal Neoplasms

NCT00408772 2017-06-09

Oxaliplatin, Capecitabine, and Bevacizumab Followed By Surgery and/or Radiofrequency Ablation in Patients With Colorectal Cancer

Phase 2 Withdrawn

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT00609765 2017-03-23

Avastin, Fluorouracil, Doxorubicin and Streptozocin in Locally Advanced and Metastatic Pancreatic Endocrine Tumors

1 enrolled 3 charts

Neoplasm Metastasis, Neoplasms, Pancreatic Neoplasms

NCT00537823 2016-12-20

Pre- and Post-operative FOLFOX Based Therapy for Patients With Colorectal Cancer With Liver Involvement

9 enrolled 12 charts

Neoplasm Metastasis, Colorectal Neoplasms

NCT01322815 2016-08-15

A Pilot Trial of GI-4000 Plus Bevacizumab and Either FOLFOX or FOLFIRI

11 enrolled 8 charts

Colonic Neoplasms, Neoplasm Metastasis

NCT01183663 2016-06-03

Lenalidomide in Combination With Bevacizumab, Sorafenib, Temsirolimus, or 5-Fluorouracil, Leucovorin, Oxaliplatin (FOLFOX)

BreastCNSDermatologicGastrointestinalGenitourinaryOther hematologic neoplasmPlasma cell

180 enrolled

Breast Neoplasms, Carcinoma, Renal Cell, Colonic Neoplasms, Glioblastoma, Melanoma, Multiple Myeloma, Neoplasm Metastasis, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Hematologic Neoplasms

NCT00390416 2016-03-14

Study of Docetaxel, Cisplatin, and Fluorouracil (Modified DCF) With Bevacizumab in Patients With Unresectable or Metastatic Gastroesophageal Adenocarcinoma

48 enrolled 8 charts

Esophageal Neoplasms, Neoplasm Metastasis, Stomach Neoplasms

NCT01405430 2015-06-29

AVECC

Phase NA Completed

63 enrolled

Neoplasm Metastasis, Colorectal Neoplasms

NCT00447330 2015-02-13

XAGastric

60 enrolled 9 charts

Adenocarcinoma, Esophageal Neoplasms, Neoplasm Metastasis, Stomach Neoplasms

NCT00096967 2014-03-26

A Study to Evaluate Avastin in Patients Treated in a Previous Genentech-Sponsored Cancer Study

100 enrolled

BreastGastrointestinal

Breast Neoplasms, Neoplasm Metastasis, Colorectal Neoplasms

NCT00433927 2014-03-14

5-FU, Folinic Acid and Irinotecan (FOLFIRI) Plus Cetuximab Versus FOLFIRI Plus Bevacizumab in First Line Treatment Colorectal Cancer (CRC)

Phase 3 Unknown

568 enrolled