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Phase

Phase 3 2Phase EARLY_PHASE1 1

Status

Completed 2Suspended 1

Sponsor Class

OTHER 2NETWORK 1

Study Type

Interventional 3

Sponsor

Cancer Type

Gastrointestinal 3Sarcoma 1Gynecologic 1Genitourinary 1CNS 1

Conditions

Hepatoblastoma 5Ovarian Neoplasms 3Ototoxicity 3Gastrointestinal Neoplasms 3Stomach Neoplasms 2Sarcoma 2Liver Neoplasms 2Testicular Neoplasms 1Teratoma 1Rhabdomyosarcoma 1Rectal Neoplasms 1Peritoneal Neoplasms 1Pelvic Neoplasms 1Ovarian Germ Cell Cancer 1Osteosarcoma 1Neuroblastoma 1Neoplasms, Germ Cell and Embryonal 1Necrosis 1Mesothelioma, Malignant 1Medulloblastoma 1Liposarcoma 1Hearing Loss 1Fallopian Tube Neoplasms 1Desmoplastic Small Round Cell Tumor 1Colorectal Neoplasms 1Colonic Neoplasms 1Central Nervous System Neoplasms 1Brain Neoplasms 1Appendiceal Neoplasms 1Adenocarcinoma 1

Interventions

sodium thiosulfate 3Cisplatin 2Vorinostat 1Restraint, Physical 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

3 trials
RecentStart dateEnrollment
Ototoxicity × sodium thiosulfate × Gastrointestinal × Clear all
NCT05756660 2025-10-20

Sodium Thiosulfate Otoprotection During Salvage Cisplatin Therapy

Children's Hospital Medical Center, Cincinnati

Phase EARLY_PHASE1 Suspended
33 enrolled
Gastrointestinal

Ototoxicity, Neoplasms, Germ Cell and Embryonal, Hepatoblastoma

NCT00716976 2023-11-09

Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy

Children's Oncology Group

Phase 3 Completed
131 enrolled 18 charts 1 FDA
CNSGastrointestinalGenitourinaryGynecologicSarcoma

Ovarian Germ Cell Cancer, Ototoxicity, Brain Neoplasms, Liver Neoplasms, Medulloblastoma, Neuroblastoma, Ovarian Neoplasms, Sarcoma, Osteosarcoma, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Hepatoblastoma

NCT00652132 2018-05-29

SIOPEL6

University of Birmingham

Phase 3 Completed
116 enrolled 1 FDA
Gastrointestinal

Ototoxicity, Liver Neoplasms, Hepatoblastoma

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