Clinical Trials

385 enrolled 17 charts 4 FDA

GastrointestinalOther solid neoplasm

Microsatellite Unstable Colorectal Cancer

NCT04472429 2025-11-03

Carboplatin-paclitaxel With Retifanlimab or Placebo in Participants With Locally Advanced or Metastatic Squamous Cell Anal Carcinoma (POD1UM-303/InterAACT 2).

308 enrolled 17 charts 3 FDA

Anus Neoplasms, Carcinoma, Squamous Cell

NCT04466891 2025-09-15

HERIZON-BTC-01

87 enrolled 25 charts 3 FDA

Biliary Tract Neoplasms, Gallbladder Neoplasms

NCT03597295 2025-08-21

A Study of INCMGA00012 in Squamous Carcinoma of the Anal Canal Following Platinum-Based Chemotherapy (POD1UM-202)

94 enrolled 18 charts 3 FDA

Squamous Cell Carcinoma of Anal Canal

NCT02924376 2025-08-14

Efficacy and Safety of Pemigatinib in Subjects With Advanced/Metastatic or Surgically Unresectable Cholangiocarcinoma Who Failed Previous Therapy - (FIGHT-202)

147 enrolled 22 charts 3 FDA

Acrocephalosyndactylia, Cholangiocarcinoma

NCT02872116 2025-08-07

CheckMate649

2,031 enrolled 19 charts 2 FDA

590 enrolled 58 charts 8 FDA

Adenocarcinoma Of Esophagus, Stomach Neoplasms

NCT03037385 2025-05-31

ARROW

Phase 1/2 Completed

EndocrineGastrointestinalHead & NeckNETThoracic

Thyroid Cancer, Papillary, Adenocarcinoma, Adenocarcinoma, Papillary, Bronchial Neoplasms, Carcinoma, Carcinoma, Bronchogenic, Carcinoma, Non-Small-Cell Lung, Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Endocrine System Diseases, Endocrine Gland Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Lung Diseases, Lung Neoplasms, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Germ Cell and Embryonal, Neoplasms, Glandular and Epithelial, Neoplasms, Nerve Tissue, Respiratory Tract Diseases, Respiratory Tract Neoplasms, Thoracic Neoplasms, Thyroid Diseases, Thyroid Neoplasms, Colorectal Neoplasms, Neuroectodermal Tumors, Carcinoma, Medullary, Carcinoma, Neuroendocrine, Neuroendocrine Tumors, Multiple Endocrine Neoplasia Type 2a

NCT04322539 2025-04-04

FRESCO-2

691 enrolled 26 charts 2 FDA

407 enrolled 45 charts 2 FDA

Colonic Neoplasms, Colorectal Neoplasms

NCT02052778 2025-03-27

A Study of TAS-120 in Patients With Advanced Solid Tumors

Phase 1/2 Completed

BreastGastrointestinal

Breast Neoplasms, Stomach Neoplasms, Cholangiocarcinoma

NCT03043313 2024-11-26

Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal Cancer

117 enrolled 21 charts 2 FDA

Colorectal Neoplasms

NCT03189719 2024-10-15

KEYNOTE-590

749 enrolled 40 charts 2 FDA

Parkinson Disease 4, Autosomal Dominant Lewy Body, Esophageal Neoplasms

NCT02563002 2024-10-03

KEYNOTE-177

307 enrolled 16 charts 3 FDA

Parkinson Disease 4, Autosomal Dominant Lewy Body, Colorectal Neoplasms

NCT04737187 2024-09-24

SUNLIGHT

492 enrolled 22 charts 2 FDA

Colorectal Neoplasms

NCT02702414 2024-09-04

KEYNOTE-224

156 enrolled 17 charts 2 FDA

Parkinson Disease 4, Autosomal Dominant Lewy Body, Carcinoma, Hepatocellular

NCT02500043 2024-09-03

Study of TAS-102 or Placebo Plus BSC in Patients With Metastatic Gastric Cancer

507 enrolled 17 charts 2 FDA

Stomach Neoplasms

NCT02989857 2024-08-20

ClarIDHy

187 enrolled 34 charts 2 FDA

Cholangiocarcinoma

NCT02928224 2023-12-21

BEACON CRC

702 enrolled 82 charts 3 FDA

Colorectal Neoplasms

NCT00716976 2023-11-09

Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy

131 enrolled 18 charts 2 FDA

CNSGastrointestinalGenitourinaryGynecologicSarcoma

Ovarian Germ Cell Cancer, Ototoxicity, Brain Neoplasms, Liver Neoplasms, Medulloblastoma, Neuroblastoma, Ovarian Neoplasms, Sarcoma, Osteosarcoma, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Hepatoblastoma

NCT03434379 2023-10-23

IMbrave150

558 enrolled 48 charts 3 FDA

Carcinoma, Hepatocellular

NCT02184195 2023-09-13

POLO

154 enrolled 20 charts 2 FDA

Pancreatic Neoplasms

NCT02034110 2023-08-21

Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Cancers

206 enrolled 40 charts 4 FDA

CNSEndocrineGastrointestinalHead & NeckOther hematologic neoplasmPlasma cellSarcoma

Nonseminomatous germ cell tumor, Biliary Tract Neoplasms, Glioma, Leukemia, Hairy Cell, Multiple Myeloma, Neoplasms, Gastrointestinal Stromal Tumors, Thyroid Carcinoma, Anaplastic

NCT02564263 2023-03-13

KEYNOTE-181

628 enrolled 27 charts 2 FDA

Parkinson Disease 4, Autosomal Dominant Lewy Body, Esophageal Neoplasms

NCT02435433 2023-01-20

REACH-2

399 enrolled 22 charts 2 FDA

Carcinoma, Hepatocellular, Liver Neoplasms

NCT03353753 2022-11-21

INVICTUS

129 enrolled 19 charts 3 FDA

GastrointestinalSarcoma

Gastrointestinal Stromal Tumors

NCT02559687 2022-09-14

KEYNOTE-180

121 enrolled 14 charts 2 FDA

Parkinson Disease 4, Autosomal Dominant Lewy Body, Esophageal Neoplasms

NCT02335411 2022-08-08

KEYNOTE-059

318 enrolled 24 charts 2 FDA

NCT02569242 2022-07-06

Study of Nivolumab in Unresectable Advanced or Recurrent Esophageal Cancer

419 enrolled 20 charts 3 FDA

250 enrolled 36 charts 3 FDA

Esophageal Neoplasms

NCT02508532 2022-06-21

(NAVIGATOR) Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors

Phase 1 Completed

GastrointestinalSarcoma

Gastrointestinal Stromal Tumors

NCT01761266 2022-04-05

A Multicenter, Open-Label, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib (E7080) Versus Sorafenib in First-line Treatment of Participants With Unresectable Hepatocellular Carcinoma

954 enrolled 19 charts 2 FDA

Carcinoma, Hepatocellular, Neoplasms

NCT03329690 2022-03-18

DS-8201a in Human Epidermal Growth Factor Receptor 2 (HER2)-Expressing Gastric Cancer [DESTINY-Gastric01]

233 enrolled 26 charts 2 FDA