Clinical Trials

Pancreatic Adenocarcinoma Locally Advanced

NCT07070700 2025-08-12

CASTLE-ZS-02

Phase 2 Recruiting

56 enrolled

Cirrhosis, Familial, with Pulmonary Hypertension, Cholangiocarcinoma

NCT02534233 2025-08-01

ColdPlay2

Phase NA Completed

58 enrolled 10 charts

Barrett Esophagus, Esophageal Neoplasms

NCT02380443 2025-05-16

AlloStim® Immunotherapy Dosing Alone or in Combination With Cryoablation in Metastatic Colorectal Cancer

13 enrolled 8 charts

Neoplasm Metastasis, Colorectal Neoplasms

NCT05010668 2025-02-21

Cryoablation Combined With Sintilimab Plus Lenvatinib in Patients With Advanced Intrahepatic Cholangiocarcinoma

28 enrolled

Cholangiocarcinoma

NCT05302921 2025-01-01

Neoadjuvant Dual Checkpoint Inhibition and Cryoablation in Relapsed/Refractory Pediatric Solid Tumors

CNSDermatologicGastrointestinalGenitourinarySarcoma

5 enrolled

Carcinoma, Hepatocellular, Melanoma, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma

NCT06530784 2024-07-31

Cryoablation Combined With PD-1 Antibody and Bevacizumab for Hepatocellular Carcinoma

Phase 2 Not yet recruiting

36 enrolled

Carcinoma, Hepatocellular

NCT06265350 2024-02-20

Cryoablation Combined With Cardonilizumab and Bevacizumab in Hepatocellular Carcinoma With Pulmonary Metastases

Phase NA Recruiting

80 enrolled

Carcinoma, Hepatocellular, Liver Neoplasms

NCT05893056 2023-06-27

CASTLE-09

25 enrolled

Gastric Cancer Metastatic to Liver

NCT05897268 2023-06-27

CASTLE-10

25 enrolled

Carcinoma, Hepatocellular

NCT00002997 2023-06-15

Cryosurgery in Treating Patients With Unresectable Liver Metastases From Colorectal Cancer

Colonic Neoplasms, Neoplasm Metastasis, Rectal Neoplasms, Colorectal Neoplasms

NCT02821754 2023-03-28

A Pilot Study of Combined Immune Checkpoint Inhibition in Combination With Ablative Therapies in Subjects With Hepatocellular Carcinoma (HCC) or Biliary Tract Carcinomas (BTC)

54 enrolled 14 charts

Diabetes Mellitus, Insulin-Dependent, 12, Bile Duct Neoplasms, Biliary Tract Neoplasms, Carcinoma, Hepatocellular, Liver Neoplasms, Cholangiocarcinoma

NCT05781074 2023-03-24

CASTLE-08

25 enrolled

Advanced Biliary Tract Cancer

NCT01293448 2022-04-28

Evaluation of Balloon-based Cryoablation of Human Esophageal Epithelium

Phase NA Completed

21 enrolled

Barrett Esophagus, Esophageal Neoplasms

NCT04724226 2021-09-05

C-couple

34 enrolled

Carcinoma, Hepatocellular

NCT01335945 2021-07-16

Safety and Efficacy of Cryoablation for Abdominal Pain Associated With Pancreatic Cancer

Phase 1 Terminated

14 enrolled

Pain, Pancreatic Neoplasms, Abdominal Pain

NCT03183219 2020-07-13

Safety and Efficiency of γδ T Cell Against Liver Cancer

30 enrolled

Liver Neoplasms

NCT01065441 2020-01-22

Experimental Therapeutic Cancer Vaccine Created In-situ in Patients With Stage II-Stage IV Cancer

BreastDermatologicGastrointestinalGenitourinaryGynecologicSarcomaThoracic

9 enrolled

Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Gastrointestinal Neoplasms, Melanoma, Ovarian Neoplasms, Prostatic Neoplasms, Sarcoma, Colorectal Neoplasms

NCT01741038 2020-01-22

AlloStim® In-Situ Vaccine in Pre-Treated Metastatic Colorectal Cancer

Phase 2/3 Withdrawn

Colorectal Neoplasms

NCT01853618 2019-12-10

Tremelimumab With Chemoembolization or Ablation for Liver Cancer

61 enrolled 18 charts

Biliary Tract Neoplasms, Carcinoma, Hepatocellular, Liver Neoplasms

NCT02843581 2019-09-12

Combination of Cryosurgery and NK Immunotherapy for Advanced Esophageal Cancer

60 enrolled

Esophageal Neoplasms

NCT02843802 2019-09-12

Combination of Cryosurgery and NK Immunotherapy for Advanced Liver Cancer

30 enrolled

Liver Neoplasms

NCT02849015 2019-09-12

Combination of Cryosurgery and NK Immunotherapy for Tumors in Transplanted Liver

20 enrolled

Carcinoma, Hepatocellular

NCT03239184 2019-01-25

Bioinformation Therapy for Pancreatic Cancer

Phase 2/3 Completed

120 enrolled

Phase EARLY_PHASE1 Terminated

Unresectable Pancreatic Cancer

NCT00499733 2019-01-18

Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer

19 enrolled

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckLymphoidSarcomaThoracic

Squamous Cell Carcinoma of Head and Neck, Uveal Melanoma, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Chondrosarcoma, Colonic Neoplasms, Carcinoma, Hepatocellular, Melanoma, Neoplasms, Neoplasms, Unknown Primary, Pancreatic Neoplasms, Prostatic Neoplasms, Salivary Gland Neoplasms, Sarcoma, Osteosarcoma, Tongue Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Esthesioneuroblastoma, Olfactory, Breast Neoplasms, Male, Small Cell Lung Carcinoma, Intraocular Lymphoma

NCT03223142 2017-07-21

SMTATS

Phase NA Unknown

100 enrolled

Liver Neoplasms, Neoplasm Metastasis

NCT02545556 2016-08-29

Liver Cancer HepaSphere Combined With Cryosurgery

60 enrolled

Liver Neoplasms

NCT00002655 2013-07-22

Cryosurgery in Treating Patients With Liver Cancer or Liver Metastases