Clinical Trials

Adenocarcinoma Of Esophagus, Stomach Neoplasms

NCT07222800 2026-04-08

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

Phase 3 Recruiting

800 enrolled

Colonic Diseases, Colonic Neoplasms, Digestive System Diseases, Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Intestinal Diseases, Intestinal Neoplasms, Neoplasm Metastasis, Neoplasms by Site, Rectal Diseases, Colorectal Neoplasms

NCT06504615 2026-04-03

METAGIO

Active not recruiting

208 enrolled

Adenocarcinoma Of Esophagus, Esophageal Squamous Cell Carcinoma, Adenocarcinoma

NCT06731478 2026-03-16

Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

Phase 3 Recruiting

726 enrolled

Phase 2/3 Not yet recruiting

Stomach Neoplasms

NCT07454720 2026-03-06

A Randomized, Double-blind, Placebo-controlled, Multicenter Phase II/III Clinical Study of Adebrelimab in Combination With SHR-8068 and Chemoradiotherapy as Perioperative Therapy for Locally Advanced Rectal Cancer

165 enrolled

Locally Advanced Resectable Rectal Cancer

NCT04900818 2026-03-05

Study of TJ033721 (Givastomig) in Subjects With Advanced or Metastatic Solid Tumors

Phase 1 Recruiting

330 enrolled

Phase 1/2 Active not recruiting

Adenocarcinoma Of Esophagus, Biliary Tract Neoplasms, Neoplasm Metastasis, Stomach Neoplasms

NCT04868877 2026-02-19

Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination

194 enrolled

GastrointestinalHead & Neck

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Head and Neck Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT05731947 2026-01-29

Evaluation of Revumenib in Participants With Colorectal Cancer and Other Solid Tumors

42 enrolled

Phase NA Not yet recruiting

Colorectal Neoplasms

NCT07325214 2026-01-12

Chemotherapy With or Without IMD10 (Focused Ultrasound) in the Treatment of Borderline Resectable or Locally Advanced Pancreatic Cancer

136 enrolled

Phase 3 Active not recruiting

Pancreatic Neoplasms

NCT05111626 2025-12-15

FORTITUDE-102

515 enrolled

Phase 3 Not yet recruiting

Stomach Neoplasms

NCT07262567 2025-12-03

Phase III Study to Compare GFH375 and Chemotherapy in Patients With KRAS G12D-Mutant Metastatic Pancreatic Cancer

320 enrolled

Phase 1/2 Active not recruiting

Pancreatic Neoplasms

NCT04888312 2025-10-08

OPTIMIZE-1

94 enrolled

Pancreatic Neoplasms

NCT02327078 2025-08-14

A Study of the Safety, Tolerability, and Efficacy of Epacadostat Administered in Combination With Nivolumab in Select Advanced Cancers (ECHO-204)

CNSDermatologicGastrointestinalGynecologicHead & NeckLymphoidThoracic

307 enrolled 27 charts

Glioblastoma, Head and Neck Neoplasms, Lung Neoplasms, Lymphoma, Melanoma, Ovarian Neoplasms, Colorectal Neoplasms

NCT04082364 2025-06-08

MAHOGANY

Phase 2/3 Completed

82 enrolled 22 charts

Phase 1 Active not recruiting

Stomach Neoplasms

NCT05704985 2025-05-29

Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors

39 enrolled

DermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Kidney Neoplasms, Neoplasms, Pancreatic Neoplasms, Skin Neoplasms, Colorectal Neoplasms

NCT02807181 2025-05-09

SIRCCA

Phase 2/3 Terminated

89 enrolled 23 charts

Cholangiocarcinoma

NCT06962267 2025-05-08

A Clinical Study on the First-line Treatment of Metastatic Pancreatic Cancer With TQB2916 Injection Combined With Gemcitabine Hydrochloride for Injection and Paclitaxel for Injection (Albumin-bound Type)

Phase 2 Recruiting

50 enrolled

Pancreatic Neoplasms

NCT04028479 2024-12-18

ROOT

BreastCNSDermatologicEndocrineGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidMyeloidNETOther hematologic neoplasmOther solid neoplasmPlasma cellSarcomaThoracic

167 enrolled

Nasopharyngeal Carcinoma, Adenocarcinoma, Adrenal Gland Neoplasms, Anus Neoplasms, Appendiceal Neoplasms, Astrocytoma, Bile Duct Neoplasms, Urinary Bladder Neoplasms, Bone Neoplasms, Brain Neoplasms, Breast Neoplasms, Carcinoid Tumor, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Chondrosarcoma, Colonic Neoplasms, Carcinoma, Adenoid Cystic, Esophageal Neoplasms, Fallopian Tube Neoplasms, Glioblastoma, Head and Neck Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Liposarcoma, Liver Neoplasms, Lung Neoplasms, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Melanoma, Mesothelioma, Multiple Myeloma, Neoplasms, Multiple Endocrine Neoplasia, Neoplasms, Unknown Primary, Ovarian Neoplasms, Pancreatic Neoplasms, Parathyroid Neoplasms, Parotid Neoplasms, Penile Neoplasms, Pharyngeal Neoplasms, Pheochromocytoma, Prostatic Neoplasms, Rectal Neoplasms, Salivary Gland Neoplasms, Sarcoma, Sarcoma, Kaposi, Osteosarcoma, Skin Neoplasms, Stomach Neoplasms, Sarcoma, Synovial, Testicular Neoplasms, Thymus Neoplasms, Thyroid Neoplasms, Tongue Neoplasms, Ureteral Neoplasms, Uterine Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Colorectal Neoplasms, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Leukemia, Myeloid, Acute, Central Nervous System Neoplasms, Cholangiocarcinoma, Carcinoma, Small Cell, Neuroendocrine Tumors, Brain Stem Neoplasms, Gestational Trophoblastic Disease, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT02826486 2024-08-28

COMBAT

Phase 2 Completed

80 enrolled 13 charts

BreastGastrointestinalThoracic

Metastatic Pancreatic Adenocarcinoma

NCT04638751 2024-04-05

ARGONAUT: Stool and Blood Sample Bank for Cancer Patients

Recruiting

5,000 enrolled

Carcinoma, Non-Small-Cell Lung, Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms, Triple Negative Breast Neoplasms

NCT03329950 2024-03-28

A Study of CDX-1140 (CD40) as Monotherapy or in Combination in Patients With Advanced Malignancies

Phase 1 Completed

132 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckLymphoidThoracic

Bile Duct Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Esophageal Neoplasms, Fallopian Tube Neoplasms, Gastrointestinal Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Liver Neoplasms, Lung Neoplasms, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Melanoma, Mouth Neoplasms, Oropharyngeal Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Lymphoma, Large B-Cell, Diffuse, Cholangiocarcinoma, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Hyper-IgM Immunodeficiency Syndrome

NCT04431258 2024-03-18

PanC-ASAP

150 enrolled

Pancreatic Neoplasms

NCT01732783 2022-11-08

Observational Study of Vectibix With Chemotherapy for Metastatic Colorectal Cancer Patients

213 enrolled 30 charts

Colorectal Neoplasms

NCT01676259 2021-07-02

PROTACT

Phase 2 Unknown

80 enrolled

Neoplasms, Pancreatic Neoplasms

NCT04229537 2020-01-18

Study of SCT-I10A Combined SCT200 or SCT-I10A Combined SCT200 Plus Chemotherapy in ESCC and CRC

Phase 1 Unknown

60 enrolled

Esophageal Squamous Cell Carcinoma, Colorectal Neoplasms

NCT02082522 2019-08-28

Efficacy and Safety Study of PDT Using Photofrin in Unresectable Advanced Perihilar Cholangiocarcinoma (OPUS)

Phase 3 Terminated

28 enrolled 24 charts

Bile Duct Neoplasms, Cholangiocarcinoma, Klatskin Tumor

NCT02305615 2018-08-23

AVACONT

300 enrolled

Colorectal Neoplasms

NCT01712347 2018-07-31

An Observational Study of First-Line Bevacizumab (Avastin) With Fluoropyrimidine-Based Chemotherapy in Participants With Metastatic Colorectal Cancer

351 enrolled

Colorectal Neoplasms

NCT02831842 2018-01-26

A Real World Study to Evaluate Effectiveness of Avastin (Bevacizumab) for First Line Treatment of Patients With Metastatic Colorectal Cancer and Known KRAS Status

4,278 enrolled

Colorectal Neoplasms

NCT01696695 2017-03-23

AXEL

882 enrolled 12 charts

Colorectal Neoplasms

NCT00510627 2017-03-03

Prometheus

Phase 4 Withdrawn

Liver Neoplasms, Colorectal Neoplasms

NCT02997241 2016-12-20

CCTDRP

Phase NA Unknown

500 enrolled

Colonic Neoplasms, Recurrence

NCT02873520 2016-10-07

Precision Cell Immunotherapy Combined With Chemotherapy in Advanced Gastric Cancer

Phase 1/2 Unknown

40 enrolled

Precision Cell Immunotherapy

NCT02215837 2016-05-24

Study of Autologous Tumor Lysate-pulsed D-CIK Combined With Chemotherapy for Gastric Cancer

Phase 2 Unknown

40 enrolled

Digestive System Neoplasms, Gastrointestinal Diseases, Gastrointestinal Neoplasms, Neoplasms, Stomach Neoplasms

NCT02202928 2015-12-28

Adoptive Cell Therapy Plus Chemotherapy and Radiation After Surgery in Treating Patients With Colorectal Cancer

Phase 2 Unknown

60 enrolled

Digestive System Neoplasms, Gastrointestinal Diseases, Intestinal Neoplasms, Neoplasms, Colorectal Neoplasms

NCT00700102 2015-07-30

A Study of Avastin (Bevacizumab) Plus Crossover Fluoropyrimidine-Based Chemotherapy in Patients With Metastatic Colorectal Cancer.

Phase 3 Completed

820 enrolled 13 charts

Colorectal Neoplasms

NCT00711191 2013-12-24

A Study On An Immunostimulant Antibody In Combination With Chemotherapy For Advanced Cancer Of The Pancreas

Phase 1 Completed

22 enrolled 12 charts

Pancreatic Neoplasms

NCT00358566 2008-05-19

GV1001 and Gemcitabine in Sequential Combination to Gemcitabine Monotherapy in Pancreatic Cancer

Phase 3 Terminated

360 enrolled

Adenocarcinoma, Pancreatic Neoplasms

NCT00083785 2007-04-11

Study of the Litx™ System Combined With Chemotherapy in Patients With Colorectal Liver Metastases

Phase 2 Completed

25 enrolled

Liver Neoplasms, Neoplasm Metastasis, Colorectal Neoplasms

NCT00068068 2006-09-19

Photodynamic Therapy With Talaporfin Sodium (LS11) in Treating Patients With Refractory Colorectal Liver Metastases

Phase 2 Completed

25 enrolled

Liver Neoplasms, Neoplasm Metastasis, Colorectal Neoplasms

NCT00041808 2005-06-24

Magnetic-Targeted Doxorubicin in Treating Patients With Cancer Metastatic to the Liver