Clinical Trials

Colorectal Neoplasms

NCT05419479 2026-02-24

Switch Maintenance in Pancreatic

Phase 1/2 Suspended

46 enrolled

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Pancreatic Neoplasms

NCT04485013 2026-02-18

TTX-080 HLA-G Antagonist in Subjects With Advanced Cancers

Phase 1 Recruiting

240 enrolled

Adenocarcinoma of Lung, Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Renal Cell, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Kidney Neoplasms, Lung Neoplasms, Melanoma, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms, Endometrial Neoplasms, Triple Negative Breast Neoplasms

NCT07323576 2026-02-09

INAVO-CRC

Phase 2 Withdrawn

Colorectal Neoplasms

NCT00208260 2026-02-05

Intensified Chemotherapy in CRC After Resection of Liver Metastases

Phase 2/3 Completed

124 enrolled

Colorectal Neoplasms

NCT04587128 2026-02-05

Early-Line Anti-EGFR Therapy to Facilitate Retreatment for Select Patients With mCRC

34 enrolled

Phase 2 Not yet recruiting

Colorectal Neoplasms

NCT07381309 2026-02-02

VVSHIP

114 enrolled

Phase 2 Not yet recruiting

CRC

NCT07359456 2026-01-22

COLIBRI-GI

130 enrolled

Colorectal Neoplasms

NCT06106308 2026-01-12

Study of Onvansertib in Combination With FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab Versus FOLFIRI and Bevacizumab or FOLFOX and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer in Adult Participants With a KRAS or NRAS Mutation

113 enrolled

Colorectal Neoplasms

NCT03803553 2025-12-23

Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer

Phase 3 Recruiting

400 enrolled

Colonic Neoplasms

NCT05008809 2025-12-12

AIO-KRK-0418

Phase 3 Recruiting

507 enrolled

CNSGastrointestinalHead & NeckMyeloidThoracic

Colorectal Neoplasms

NCT05786924 2025-11-20

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

Phase 1/2 Recruiting

554 enrolled

Brain Neoplasms, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Thyroid Neoplasms, Colorectal Neoplasms, Histiocytosis

NCT06747845 2025-09-16

ParpVax2

Phase 2 Recruiting

68 enrolled

Pancreatic Adenocarcinoma Metastatic

NCT06867822 2025-08-24

Trial of ProAgio in Advanced/Metastatic Colorectal Cancer

Phase 1 Recruiting

27 enrolled

Colorectal Neoplasms

NCT05480306 2025-08-03

DeFianCe

188 enrolled

Colonic Neoplasms, Colorectal Neoplasms

NCT03186326 2025-06-29

SAMCO

132 enrolled

Phase 2 Not yet recruiting

Colorectal Neoplasms

NCT07021950 2025-06-15

AK112 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI as Second-line Treatment of MSS/pMMR Metastatic Colorectal Cancer

130 enrolled

Colorectal Neoplasms

NCT04554836 2025-06-08

MoLiMoR - A Study With FOLFIRI-based First-line Therapy With or Without Intermittent Cetuximab

6 enrolled 9 charts

Colonic Neoplasms, Rectal Neoplasms

NCT05312398 2025-05-25

CAPRI 2 GOIM Study: Investigate the Efficacy and Safety of a Bio-marker Driven Cetuximab-based Treatment Regimen

219 enrolled

Metastatic Colorectal Adenocarcinoma

NCT05848739 2025-05-11

A Phase 1-2 of ST316 With Selected Advanced Unresectable and Metastatic Solid Tumors

Phase 1 Recruiting

130 enrolled

Colonic Neoplasms

NCT05004350 2025-04-15

NAUTICALCRC

107 enrolled

Colorectal Neoplasms

NCT03597581 2025-04-03

A Study of RGX-202-01 (Ompenaclid) as Combination Therapy in RAS Mutant Advanced Colorectal Cancer

89 enrolled

GastrointestinalLymphoidOther hematologic neoplasmSarcoma

Gastrointestinal Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT04553692 2025-03-28

Phase 1a/1b Study of Aplitabart (IGM-8444) Alone or in Combination in Participants with Relapsed, Refractory, or Newly Diagnosed Cancers

Phase 1 Terminated

272 enrolled

Chondrosarcoma, Lymphoma, Non-Hodgkin, Neoplasm Metastasis, Sarcoma, Colorectal Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, Myeloid, Acute

NCT04952753 2025-03-26

daNIS-3

Phase 2 Terminated

204 enrolled

Colorectal Neoplasms

NCT04256707 2025-03-19

SPRINT

Phase 1/2 Completed

126 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms

NCT03829410 2025-03-04

Onvansertib in Combination With FOLFIRI and Bevacizumab for Second Line Treatment of Metastatic Colorectal Cancer Patients With a KRAS Mutation

Phase 1/2 Completed

68 enrolled 21 charts

Colorectal Neoplasms

NCT05087992 2025-02-19

A Study to Find the Best Dose of BI 905711 in Combination With Chemotherapy and to Test Whether This Dose Helps People With Advanced Gastrointestinal Cancers

13 enrolled 17 charts

Gastrointestinal Neoplasms, Neoplasm Metastasis

NCT06640166 2025-02-12

ECLYPse

Phase 2 Recruiting

25 enrolled

Colonic Neoplasms, Colorectal Neoplasms

NCT03117972 2025-02-05

CLavSyn

Phase 2 Terminated

54 enrolled

Colorectal Neoplasms

NCT05593328 2025-01-10

Study of Onvansertib in Combination With FOLFIRI and Bevacizumab Versus FOLFIRI and Bevacizumab for Second Line Treatment of Metastatic Colorectal Cancer in Participants With a Kirsten Rat Sarcoma Virus Gene (KRAS) or Neuroblastoma-RAS (NRAS) Mutation

23 enrolled

307 enrolled 16 charts 3 FDA

Colorectal Neoplasms

NCT02563002 2024-10-03

KEYNOTE-177

Phase 3 Completed

Parkinson Disease 4, Autosomal Dominant Lewy Body, Colorectal Neoplasms

NCT05084859 2024-08-09

A Study Evaluating the Safety, Pharmacokinetics, and Preliminary Efficacy of Orally Administered SM08502 Combined With Hormonal Therapy or Chemotherapy in Subjects With Advanced Solid Tumors

Phase 1 Terminated

30 enrolled

GastrointestinalThoracic

Carcinoma, Non-Small-Cell Lung, Colorectal Neoplasms

NCT05039944 2024-07-18

SI-B001 as a Single Agent or in Combination With Chemotherapy in the Treatment of Digestive System Malignancies

Phase 2 Terminated

7 enrolled

Colorectal Neoplasms

NCT03959293 2024-07-08

Clinical Trial Evaluating FOLFIRI + Durvalumab vs FOLFIRI + Durvalumab and Tremelimumab in Second-line Treatment of Patients With Advanced Gastric or Gastro-oesophageal Junction Adenocarcinoma

107 enrolled

Stomach Neoplasms

NCT03250832 2024-04-11

CITRINO

GastrointestinalGynecologicThoracic

111 enrolled 48 charts

Lung Neoplasms, Neoplasms, Ovarian Neoplasms, Colorectal Neoplasms

NCT01946074 2023-12-15

A Study of ABT-165 in Subjects With Solid Tumors

101 enrolled

Neoplasms, Colorectal Neoplasms

NCT01133990 2023-11-07

FOLFIRI Alone Versus FOLFIRI Plus Bevacizumab Versus FOLFIRI Plus E7820 as Second-Line Therapy in Patients With Locally Advanced or Metastatic Colorectal Cancer

Phase 1/2 Terminated

5 enrolled 12 charts

Colorectal Neoplasms

NCT04259944 2023-09-28

Post-surgical Liquid Biopsy-guided Treatment of Stage III and High-risk Stage II Colon Cancer Patients: the PEGASUS Trial

Phase 2 Unknown

140 enrolled

Colonic Neoplasms, Colorectal Neoplasms

NCT01726582 2023-08-14

Pancreas Cancer: Molecular Profiling as a Guide to Therapy Before and After Surgery ("Personalized Medicine")

229 enrolled 14 charts

Adenocarcinoma, Neoplasms, Pancreatic Neoplasms

NCT01347645 2023-06-22

Irinotecan Plus E7820 Versus FOLFIRI in Second-Line Therapy in Patients With Locally Advanced or Metastatic Colon or Rectal Cancer

Phase 1/2 Terminated

82 enrolled 14 charts

Colonic Neoplasms, Rectal Neoplasms

NCT05684211 2023-02-01

A Study of Ametumumab in Combination With Anti-PD-1 Monoclonal Antibody and FOLFIRI in Patients With RAS Wild-type Advanced Colorectal Cancer

Phase 2 Unknown

84 enrolled