Clinical Trials Browser

Interventional × Metformin × Gastrointestinal × Clear all

NCT04114136 2026-04-24

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Phase 2 Recruiting

DermatologicGastrointestinalHead & Neck

Adenocarcinoma Of Esophagus, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hepatocellular, Melanoma

NCT02437656 2026-03-31

METCAP

Phase 2 Completed

Gastrointestinal

Rectal Neoplasms

NCT02336087 2026-02-04

Gemcitabine Hydrochloride, Paclitaxel Albumin-Stabilized Nanoparticle Formulation, Metformin Hydrochloride, and a Standardized Dietary Supplement in Treating Patients With Pancreatic Cancer That Cannot be Removed by Surgery

Phase 1 Active not recruiting

Gastrointestinal

Pancreatic Adenocarcinoma

NCT03889795 2025-10-20

Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors

Phase 1 Active not recruiting

GastrointestinalOther solid neoplasm

Advanced Pancreatic Cancer

NCT06687876 2025-07-10

MEMENTO

Phase 2 Recruiting

Gastrointestinal

Adenocarcinoma Of Esophagus, Adenocarcinoma, Esophageal Neoplasms

NCT05158374 2025-02-06

Molecular Effects of Aspirin & Metformin on Colonic Epithelium

Phase NA Withdrawn

Gastrointestinal

Colorectal Neoplasms

NCT03047837 2025-01-27

ASAMET

Phase 2 Terminated

Gastrointestinal

Colorectal Neoplasms

NCT03800602 2024-09-05

Nivolumab and Metformin in Patients With Treatment Refractory MSS Colorectal Cancer

Phase 2 Completed

29 enrolled 7 charts

Gastrointestinal

Colorectal Neoplasms

NCT02431676 2024-08-28

SPIRIT

Phase 2 Completed

121 enrolled 12 charts

BreastDermatologicGastrointestinalGenitourinaryGynecologicThoracic

Breast Neoplasms, Colonic Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Endometrial Neoplasms

NCT06030622 2024-04-19

C3

Phase 1/2 Unknown

Gastrointestinal

Pancreatic Neoplasms

NCT05921942 2024-02-02

The Impact of Metformin Administration on the Clinical Outcome of Stage IV Colon Cancer

Phase 3 Completed

Gastrointestinal

Colorectal Neoplasms

NCT04033107 2023-09-28

High Dose Vitamin C Combined With Metformin in the Treatment of Malignant Tumors

Phase 2 Unknown

Gastrointestinal

Liver Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Colorectal Neoplasms

NCT02201381 2022-07-18

METRICS

Phase 3 Withdrawn

BreastCNSGastrointestinalGynecologic

Brain Neoplasms, Breast Neoplasms, Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Triple Negative Breast Neoplasms

NCT03359681 2022-03-03

MECORA

Phase 2 Completed

Gastrointestinal

Colonic Neoplasms

NCT01725490 2021-09-20

The Chemopreventive Effect of Metformin in Patients With Familial Adenomatous Polyposis: Double Blinded Randomized Controlled Study

Phase 2 Completed

Gastrointestinal

Adenomatous Polyposis Coli

NCT01666730 2021-08-10

Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer

Phase 2 Completed

50 enrolled 13 charts

Gastrointestinal

Pancreatic Neoplasms

NCT01210911 2021-04-21

GEM

Phase 2 Completed

Gastrointestinal

Pancreatic Neoplasms

NCT02048384 2021-04-12

A Study of Metformin With or Without Rapamycin as Maintenance Therapy After Induction Chemotherapy in Subjects With Pancreatic Cancer

Phase 1 Completed

Gastrointestinal

Adenocarcinoma, Neoplasm Metastasis, Pancreatic Neoplasms

NCT02153450 2020-06-26

Stereotactic Radiosurgery and Metformin in Patients With Borderline-Resectable or Locally-Advanced Pancreatic Cancer

Phase EARLY_PHASE1 Completed

Gastrointestinal

Pancreatic Neoplasms

NCT02496741 2020-01-09

MACIST

Phase 1/2 Completed

CNSGastrointestinalSarcoma

Chondrosarcoma, Glioma, Cholangiocarcinoma

NCT03053544 2019-09-27

Metformin With Neoadjuvant Chemoradiation to Improve Pathologic Responses in Rectal Cancer

Phase 2 Completed

Gastrointestinal

Rectal Neoplasms

NCT02614339 2019-09-18

Effect of Adjunctive Metformin on Recurrence of Non-DM Colorectal Cancer Stage II High-risk/ III Colorectal Cancer

Phase 3 Unknown

Gastrointestinal

Non-DM Stage II High-risk Colorectal Cancer

NCT03184493 2019-05-31

XBD

Phase 3 Unknown

Gastrointestinal

Liver Neoplasms

NCT01312467 2019-03-05

Trial of Metformin for Colorectal Cancer Risk Reduction for History of Colorectal Adenomas and Elevated BMI

Phase 2 Completed

45 enrolled 7 charts

GastrointestinalOther

Obesity, Colorectal Neoplasms, Adenomatous Polyps

NCT03833466 2019-02-15

ECMTPneo

Phase 2 Unknown

Gastrointestinal

Esophageal Squamous Cell Carcinoma

NCT02005419 2019-02-05

Metformin Combined With Gemcitabine as Adjuvant Therapy for Pancreatic Cancer After Curative Resection

Phase 2 Completed

Gastrointestinal

Pancreatic Neoplasms

NCT01523639 2018-12-19

G-LUCAS

Phase 2 Terminated

Gastrointestinal

Fatty Liver, Colorectal Neoplasms

NCT01340300 2018-06-06

Exercise and Metformin in Colorectal and Breast Cancer Survivors

Phase 2 Completed

139 enrolled 18 charts

BreastGastrointestinal

Breast Neoplasms, Insulin Resistance, Motor Activity, Colorectal Neoplasms

NCT01926769 2018-05-15

A Phase II Study to Determine the Safety and Efficacy of Second-line Treatment With Metformin and Chemotherapy (FOLFOX6 or FOFIRI) in the Second Line Threatment of Advanced Colorectal Cancer

Phase 2 Terminated

Gastrointestinal

Colorectal Neoplasms

NCT02978547 2018-01-18

Metformin 001

Phase 2 Unknown

Gastrointestinal

Resectable Pancreatic Ductal Adenocarcinoma

NCT02473094 2017-11-28

NEOMETRE

Phase 2 Terminated

Gastrointestinal

Adenocarcinoma, Carcinoma, Rectal Neoplasms

NCT01930864 2017-06-22

Metformin Plus Irinotecan for Refractory Colorectal Cancer

Phase 2 Unknown

Gastrointestinal

Adenocarcinoma, Colorectal Neoplasms

NCT02319200 2017-01-11

METFOVIR

Phase 3 Terminated

Gastrointestinal

Death, Fibrosis, Carcinoma, Hepatocellular, Hepatitis C, Chronic

NCT01488552 2016-08-18

Gemcitabine+Nab-paclitaxel and FOLFIRINOX and Molecular Profiling for Patients With Advanced Pancreatic Cancer

Phase 1/2 Completed

Gastrointestinal

Pancreatic Neoplasms

NCT01632020 2016-07-11

Effect of Metformin on Biomarkers of Colorectal Tumor Cell Growth

Phase 2 Terminated

7 enrolled 6 charts

Gastrointestinal

Colorectal Neoplasms

NCT01465113 2016-03-10

Vitamin D Supplementation on 15-Prostaglandin Dehydrogenase Expression in Barrett's Esophagus

Phase EARLY_PHASE1 Completed

Gastrointestinal

Barrett Esophagus

NCT02672488 2016-02-03

Metformin Plus Sorafenib for Advanced HCC

Phase 2 Unknown

Gastrointestinal

Carcinoma, Hepatocellular

NCT01816659 2015-11-18

An Open-Labeled Pilot Study of Biomarker Response Following Short-Term Exposure to Metformin

Phase 1 Terminated

Gastrointestinal

Colorectal Neoplasms

NCT01954732 2015-07-15

Metformin Hydrochloride in Treating Patients With Pancreatic Cancer That Can be Removed by Surgery

Phase 1 Withdrawn

Gastrointestinal

Pancreatic Neoplasms

NCT01167738 2015-04-24

PACT-17

Phase 2 Terminated

Gastrointestinal

Pancreatic Neoplasms

NCT01941953 2015-04-08

Metformin and 5-fluorouracil for Refractory Colorectal Cancer.

Phase 2 Completed

Gastrointestinal

Colorectal Neoplasms

NCT01440127 2015-03-26

Impact of Pretreatment With Metformin on Colorectal Cancer Stem Cells (CCSC) and Related Pharmacodynamic Markers

Phase 1 Terminated

Gastrointestinal

Colonic Neoplasms

NCT01447927 2014-07-21

Metformin Hydrochloride in Preventing Esophageal Cancer in Patients With Barrett Esophagus

Phase 2 Completed

93 enrolled 10 charts

Gastrointestinal

Barrett Esophagus, Esophageal Neoplasms