Clinical Trials

Neoplasm Metastasis, Colorectal Neoplasms

NCT05661643 2026-04-07

GIST

Phase 2 Not yet recruiting

29 enrolled

GastrointestinalSarcoma

Gastrointestinal Stromal Tumors

NCT07492680 2026-03-25

A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)

260 enrolled

CNSDermatologicGastrointestinal

Brain Neoplasms, Melanoma, Pancreatic Neoplasms

NCT04457284 2026-03-13

Temozolomide, Cisplatin, and Nivolumab in People With Colorectal Cancer

18 enrolled

BreastCNSGastrointestinalGenitourinaryGynecologic

Colorectal Adenocarcinoma

NCT05417594 2026-03-12

CERTIS1

Phase 1/2 Recruiting

695 enrolled

Astrocytoma, Breast Neoplasms, Fallopian Tube Neoplasms, Glioma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms

NCT03519412 2026-03-03

ARETHUSA

107 enrolled 14 charts

Colorectal Neoplasms, Microsatellite Instability

NCT04689347 2026-01-12

5FU/LV, Irinotecan, Temozolomide and Bevacizumab for MGMT Silenced, Microsatellite Stable Metastatic Colorectal Cancer.

Phase 1/2 Recruiting

27 enrolled

Colorectal Neoplasms

NCT06630325 2026-01-07

A Precision Medicine Approach (SMMART-ACT) for the Treatment of Patients With Advanced Sarcoma, Prostate, Breast, Ovarian or Pancreatic Cancer

GastrointestinalGenitourinaryGynecologic

30 enrolled

Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms

NCT04337177 2025-09-23

Flavored, Oral Irinotecan VAL-413 (Orotecan®) Given With Temozolomide for Treatment of Recurrent Pediatric Solid Tumors

Phase 1 Recruiting

20 enrolled

CNSGastrointestinalSarcoma

Medulloblastoma, Neuroblastoma, Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Hepatoblastoma

NCT04919226 2025-09-10

COMPOSE

Phase 3 Active not recruiting

259 enrolled

Gastro-enteropancreatic neuroendocrine tumor, Neuroendocrine Tumors

NCT06490536 2025-08-29

The Sagittarius Trial

Phase 3 Recruiting

700 enrolled

Colonic Neoplasms

NCT01205828 2025-02-12

ABT-888 and Temozolomide for Liver Cancer

Phase 2 Terminated

16 enrolled 11 charts

Carcinoma, Hepatocellular, Liver Neoplasms

NCT03150810 2024-12-20

Study to Assess Safety, Tolerability and Clinical Activity of BGB-290 in Combination With Temozolomide (TMZ) in Participants With Locally Advanced or Metastatic Solid Tumors

BreastGastrointestinalGynecologicHead & NeckSarcomaThoracic

139 enrolled 36 charts

Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Head and Neck Neoplasms, Ovarian Neoplasms, Sarcoma, Stomach Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT03556384 2024-11-04

Temozolomide (TMZ) in Advanced Succinate Dehydrogenase (SDH)-Mutant/Deficient Gastrointestinal Stromal Tumor (GIST)

23 enrolled

GastrointestinalSarcoma

Hematoma, Subdural, Neoplasms, Gastrointestinal Stromal Tumors

NCT04893785 2024-06-18

CABOTEM

35 enrolled

Gastro-enteropancreatic neuroendocrine tumor

NCT03351296 2024-05-08

BETTER2

140 enrolled

Pancreatic Neoplasms

NCT01525082 2024-02-06

Capecitabine, Temozolomide, and Bevacizumab for Metastatic or Unresectable Pancreatic Neuroendocrine Tumors

EndocrineGastrointestinal

20 enrolled 15 charts

Glucagonoma, Insulinoma, Pancreatic Neoplasms, Somatostatinoma, Gastrinoma, Carcinoma, Islet Cell

NCT04984733 2023-11-29

ELEVATE

18 enrolled

Esophageal Neoplasms, Neoplasms

NCT04166435 2023-09-06

TMZ + Olaparib for MGMT Hypermethylated Colorectal Cancer

11 enrolled 13 charts

Colorectal Neoplasms

NCT05136326 2023-03-01

CATARTIC

21 enrolled

Rectal Neoplasms

NCT05031975 2022-09-02

ERASE-TMZ

Phase 2 Unknown

35 enrolled

Colorectal Neoplasms

NCT04796454 2022-06-01

PAMICC

Phase 2 Withdrawn

Biliary Tract Neoplasms

NCT03832621 2022-04-04

MAYA

135 enrolled

Colorectal Neoplasms

NCT02414009 2021-09-09

CAPTEM

82 enrolled

Colorectal Neoplasms

NCT01781403 2021-02-04

Preoperative CRT With Temozolomide Plus Capecitabine in Rectal Cancer

22 enrolled 5 charts

Rectal Neoplasms

NCT02231762 2019-05-06

SONNET

57 enrolled 20 charts

Gastroenteropancreatic Neuroendocrine Tumors

NCT01051596 2019-04-02

A Study of ABT-888 in Combination With Temozolomide for Colorectal Cancer

75 enrolled 10 charts

CNSGastrointestinalPlasma cell

Neoplasm Metastasis, Colorectal Neoplasms

NCT03607643 2018-07-31

A Study of the Efficacy of Cannabidiol in Patients With Multiple Myeloma, Glioblastoma Multiforme, and GI Malignancies

Phase 1/2 Unknown

160 enrolled

Colonic Neoplasms, Gallbladder Neoplasms, Glioblastoma, Liver Neoplasms, Multiple Myeloma, Pancreatic Neoplasms, Rectal Neoplasms

NCT00526617 2017-11-21

A Phase I Study of ABT-888 in Combination With Temozolomide in Cancer Patients

BreastDermatologicGastrointestinalGynecologic

41 enrolled

Breast Neoplasms, Fallopian Tube Neoplasms, Carcinoma, Hepatocellular, Melanoma, Ovarian Neoplasms

NCT02831179 2017-09-28

Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and Recurrent Neuroendocrine Tumor

Phase 1 Withdrawn

DermatologicEndocrineGastrointestinalNET

Non functioning pancreatic endocrine tumor, Adrenal Cortex Neoplasms, Carcinoid Tumor, Vipoma, Glucagonoma, Insulinoma, Pheochromocytoma, Somatostatinoma, Zollinger-Ellison Syndrome, Carcinoma, Merkel Cell, Carcinoma, Medullary, Neuroendocrine Tumors, Multiple Endocrine Neoplasia Type 1, Multiple Endocrine Neoplasia Type 2a, Multiple Endocrine Neoplasia Type 2b

NCT03204032 2017-06-29

A Study of Tegafur Combined With Temozolomide Versus Tegafur Combined With Temozolomide and Thalidomide in Subjects With Advanced Extrapancreatic Neuroendocrine Tumor

Phase 2 Unknown

60 enrolled

GastrointestinalHead & NeckThoracic

Extrapancreatic Neuroendocrine Tumor

NCT00423150 2017-06-08

Phase 2 Study of Temozolomide in Pre-Selected Advanced Aerodigestive Tract Cancers (Study P04273AM2)(TERMINATED)

Phase 2 Terminated

86 enrolled 6 charts

Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Head and Neck Neoplasms, Colorectal Neoplasms

NCT00869050 2016-07-25

Capecitabine and Temozolomide for Neuroendocrine Cancers

41 enrolled 9 charts

Carcinoid Tumor, Vipoma, Pancreatic Neoplasms, Pheochromocytoma, Somatostatinoma, Zollinger-Ellison Syndrome, Gastrinoma, Carcinoma, Medullary, Neuroendocrine Tumors

NCT00020150 2015-04-29

Temozolomide and O6-benzylguanine in Treating Children With Solid Tumors

CNSGastrointestinalGenitourinaryGynecologicSarcoma

Familial ependymoma, Ovarian Germ Cell Cancer, Astrocytoma, Kidney Neoplasms, Liver Neoplasms, Medulloblastoma, Wilms Tumor, Neuroblastoma, Oligodendroglioma, Ovarian Neoplasms, Sarcoma, Osteosarcoma, Teratoma, Testicular Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral, Optic Nerve Glioma

NCT00005597 2013-01-03

S9926 Temozolomide in Patients With Unresectable/Metastatic Gastrointestinal Stromal Tumors

25 enrolled

GastrointestinalSarcoma

Gastrointestinal Stromal Tumors

NCT00303940 2012-03-15

Talabostat Combined With Temozolomide or Carboplatin in Treating Young Patients With Relapsed or Refractory Brain Tumors or Other Solid Tumors