Clinical Trials Browser

Endometrial Neoplasms

NCT05768139 2026-05-22

PIKALO-1

Squamous Cell Carcinoma of Head and Neck, Breast Diseases, Breast Neoplasms, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Neoplasms, Neoplasms by Site, Hereditary Sensory and Autonomic Neuropathies, Ovarian Neoplasms, Endometrial Neoplasms

NCT02122185 2026-03-27

Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Phase 2 Completed

111 enrolled 15 charts

GynecologicThoracic

Carcinoma, Ovarian Epithelial, Brenner Tumor, Fallopian Tube Neoplasms, Pleural Effusion, Malignant

NCT04576104 2026-01-21

Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer

Phase 2 Active not recruiting

51 enrolled

Gynecologic

Endometrial Hyperplasia, Endometrial Neoplasms

NCT01797523 2025-11-06

A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial Carcinoma

Phase 2 Active not recruiting

62 enrolled

Gynecologic

Endometrial Neoplasms

NCT03675893 2025-06-15

RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer

Phase 2 Recruiting

180 enrolled

Gynecologic

Ovarian Neoplasms, Endometrial Neoplasms

NCT04275713 2025-01-20

METOXY-LACC

Phase 2 Completed

41 enrolled

Gynecologic

Uterine Cervical Neoplasms

NCT06353061 2025-01-14

Chemoradiotherapy With or Without Metformin in Locally Advanced Cervical Cancer

Phase 2 Unknown

51 enrolled

Gynecologic

Hypoxia, Uterine Cervical Neoplasms

NCT02035787 2024-12-18

Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical Patients

Phase 2 Completed

20 enrolled 12 charts

Gynecologic

Endometrial Neoplasms

NCT03378297 2024-10-30

IMPACT

Phase EARLY_PHASE1 Completed

26 enrolled

Gynecologic

Ovarian Neoplasms

NCT01686126 2024-08-28

feMMe

Phase 2 Active not recruiting

165 enrolled

Gynecologic

Endometrial Hyperplasia

NCT02431676 2024-08-28

SPIRIT

Phase 2 Completed

121 enrolled 12 charts

BreastDermatologicGastrointestinalGenitourinaryGynecologicThoracic

Breast Neoplasms, Colonic Neoplasms, Kidney Neoplasms, Liver Neoplasms, Lung Neoplasms, Melanoma, Pancreatic Neoplasms, Prostatic Neoplasms, Rectal Neoplasms, Endometrial Neoplasms

NCT02312661 2024-05-06

OVMET

Phase 1 Completed

15 enrolled

Gynecologic

Carcinoma, Ovarian Epithelial, Ovarian Neoplasms

NCT04792749 2023-04-13

Clinical Effects of Metformin on Fertility-sparing Treatment for Early Endometrial Cancer

Phase 3 Unknown

77 enrolled

Gynecologic

Endometrial Neoplasms

NCT02201381 2022-07-18

METRICS

Phase 3 Withdrawn

BreastCNSGastrointestinalGynecologic

Brain Neoplasms, Breast Neoplasms, Colonic Neoplasms, Neoplasm Metastasis, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Triple Negative Breast Neoplasms

NCT02065687 2021-09-30

Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer

Phase 2/3 Unknown

469 enrolled 16 charts

Gynecologic

Endometrial Adenocarcinoma

NCT02394652 2021-04-21

The Potential for Metformin to Improve Tumor Oxygenation in Locally Advanced Cervix Cancer: A Phase II Randomized Trial

Phase 2 Completed

16 enrolled

Gynecologic

Adenocarcinoma, Carcinoma, Squamous Cell, Uterine Cervical Neoplasms, Carcinoma, Adenosquamous

NCT02050009 2019-02-20

Metformin Hydrochloride, Carboplatin, and Paclitaxel in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Phase 1 Withdrawn

Gynecologic

Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms

NCT03538704 2018-05-29

ECFerSp

Phase NA Unknown

80 enrolled

Gynecologic

Recurrence, Endometrial Neoplasms

NCT01579812 2018-05-25

Evaluation of Metformin, Targeting Cancer Stem Cells for Prevention of Relapse in Gynecologic Patients

Phase 2 Completed

90 enrolled 9 charts

Gynecologic

Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

NCT01205672 2017-06-02

Evaluation of the Molecular Effects of Metformin on the Endometrium in Patients With Endometrial Cancer

Phase EARLY_PHASE1 Completed

21 enrolled

Gynecologic

Insulin Resistance, Endometrial Neoplasms

NCT02437812 2017-02-28

Study of Paclitaxel, Carboplatin and Oral Metformin in the Treatment of Advanced Stage Ovarian Carcinoma

Phase 2 Unknown

30 enrolled

Gynecologic

Carcinoma, Ovarian Epithelial

NCT02990728 2016-12-13

Mirena® ± Metformin as Fertility-preserving Treatment for Young Asian Women With Early Endometrial Cancer

Phase 2 Unknown

120 enrolled

Gynecologic

Endometrial Neoplasms

NCT02042495 2016-08-30

Endometrial Cancer Biomarker Changes Following Exposure to Metformin

Phase 2 Withdrawn

Gynecologic

Endometrial Neoplasms

NCT02872818 2016-08-23

Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia

Phase 4 Completed

40 enrolled

Gynecologic

Endometrial Hyperplasia, Endometrial Neoplasms

NCT01911247 2013-07-30

Preoperative Window Study of Metformin for the Treatment of Endometrial Cancer

Phase EARLY_PHASE1 Completed

28 enrolled

Gynecologic

Endometrial Neoplasms

NCT00659568 2013-05-30

Metformin and Temsirolimus in Treating Patients With Metastatic or Unresectable Solid Tumor or Lymphoma

Phase 1 Completed

28 enrolled

BreastDermatologicGenitourinaryGynecologicLymphoidOther hematologic neoplasmThoracic

Breast Neoplasms, Burkitt Lymphoma, Carcinoma, Renal Cell, Hodgkin Disease, Immunoblastic Lymphadenopathy, Kidney Neoplasms, Lung Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Waldenstrom Macroglobulinemia, Mycosis Fungoides, Sezary Syndrome, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Lymphoma, T-Cell, Cutaneous, Endometrial Neoplasms, Lymphoma, Large-Cell, Anaplastic, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Lymphoma, Extranodal NK-T-Cell, Small Cell Lung Carcinoma

Clinical Trials

ENDOLA

PIKALO-1

Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer

A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial Carcinoma

RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer

METOXY-LACC

Chemoradiotherapy With or Without Metformin in Locally Advanced Cervical Cancer

Metformin With the Levonorgestrel-Releasing Intrauterine Device for the Treatment of Complex Atypical Hyperplasia (CAH) and Endometrial Cancer (EC) in Non-surgical Patients

IMPACT

feMMe

SPIRIT

OVMET

Clinical Effects of Metformin on Fertility-sparing Treatment for Early Endometrial Cancer

METRICS

Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer

The Potential for Metformin to Improve Tumor Oxygenation in Locally Advanced Cervix Cancer: A Phase II Randomized Trial

Metformin Hydrochloride, Carboplatin, and Paclitaxel in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

ECFerSp

Evaluation of Metformin, Targeting Cancer Stem Cells for Prevention of Relapse in Gynecologic Patients

Evaluation of the Molecular Effects of Metformin on the Endometrium in Patients With Endometrial Cancer

Study of Paclitaxel, Carboplatin and Oral Metformin in the Treatment of Advanced Stage Ovarian Carcinoma

Mirena® ± Metformin as Fertility-preserving Treatment for Young Asian Women With Early Endometrial Cancer

Endometrial Cancer Biomarker Changes Following Exposure to Metformin

Apoptotic Signaling Pathways in Rats With Endometrial Hyperplasia

Preoperative Window Study of Metformin for the Treatment of Endometrial Cancer

Metformin and Temsirolimus in Treating Patients With Metastatic or Unresectable Solid Tumor or Lymphoma