Announcements Trials
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Phase

Phase 2 2Phase 1 1

Status

Active not recruiting 2Terminated 1

Sponsor Class

OTHER 2NIH 1

Study Type

Interventional 3

Sponsor

Cancer Type

Head & Neck 3

Conditions

Squamous Cell Carcinoma of Head and Neck 7Head and Neck Neoplasms 5Mouth Neoplasms 4Leukoplakia, Oral 3Erythroplasia 3Thyroid Nodule 2Thyroid Neoplasms 2Thyroid Diseases 2Insulin Resistance 2Uterine Cervical Neoplasms 1Ovarian Neoplasms 1Neoplasms by Site 1Neoplasms 1Melanoma 1Lymphoid Interstitial Pneumonia 1Leukoplakia 1Laryngeal Diseases 1Hyperplasia 1Hereditary Sensory and Autonomic Neuropathies 1Head and Neck Squamous Cell Cancer 1Endometrial Neoplasms 1Diabetes Mellitus, Type 2 1Carcinoma, Hepatocellular 1Breast Neoplasms 1Breast Diseases 1Adenocarcinoma Of Esophagus 1

Interventions

Metformin 3Biopsy 2Surveys and Questionnaires 1Spectrometry, Fluorescence 1Specimen Handling 1Optical Imaging 1Molecular Diagnostic Techniques 1Aminolevulinic Acid 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

3 trials
RecentStart dateEnrollment
Erythroplasia × Metformin × Head & Neck × Clear all
NCT05237960 2026-04-20

Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia

University of Arizona

Phase 2 Active not recruiting
34 enrolled
Head & Neck

Erythroplasia, Leukoplakia, Oral

NCT02581137 2026-04-13

Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion

National Cancer Institute (NCI)

Phase 2 Active not recruiting
26 enrolled 10 charts
Head & Neck

Erythroplasia, Hyperplasia, Leukoplakia, Oral, Mouth Neoplasms

NCT05536037 2025-05-15

Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions

Thomas Jefferson University

Phase 1 Terminated
4 enrolled
Head & Neck

Erythroplasia, Leukoplakia, Mouth Neoplasms

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