Announcements Trials
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Phase

Phase 2/3 1Phase 2 1

Status

Not yet recruiting 1Active not recruiting 1

Sponsor Class

OTHER 1NIH 1

Study Type

Interventional 2

Sponsor

Cancer Type

Myeloid 28Lymphoid 22Sarcoma 18CNS 17Genitourinary 14Gastrointestinal 14Other hematologic neoplasm 8Dermatologic 5Plasma cell 4Classical hematology 3Head & Neck 2Endocrine 2Thoracic 1Gynecologic 1

Conditions

Head and Neck Neoplasms 2603Squamous Cell Carcinoma of Head and Neck 1880Thyroid Neoplasms 704Nasopharyngeal Carcinoma 627Carcinoma, Non-Small-Cell Lung 477Mouth Neoplasms 424Breast Neoplasms 383Neoplasms 381Oropharyngeal Neoplasms 359Melanoma 339Lung Neoplasms 318Colorectal Neoplasms 307Carcinoma, Squamous Cell 282Neoplasm Metastasis 255Ovarian Neoplasms 254Laryngeal Neoplasms 253Salivary Gland Neoplasms 236Uterine Cervical Neoplasms 234Stomach Neoplasms 223Esophageal Neoplasms 222Nasopharyngeal Neoplasms 221Pancreatic Neoplasms 213Prostatic Neoplasms 203Carcinoma, Renal Cell 201Thyroid Nodule 179Thyroid Cancer, Papillary 178Urinary Bladder Neoplasms 163Sarcoma 160Recurrence 143Hypopharyngeal Neoplasms 143

Interventions

trametinib 1tipifarnib 1dabrafenib 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Histiocytosis, Langerhans-Cell × Head & Neck × Clear all
NCT04284774 2026-05-27

Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial

National Cancer Institute (NCI)

Phase 2 Active not recruiting
5 enrolled 9 charts
CNSDermatologicEndocrineGastrointestinalGenitourinaryHead & NeckLymphoidMyeloidSarcoma

Ependymoma, Glioma, Histiocytosis, Langerhans-Cell, Lymphoma, Non-Hodgkin, Medulloblastoma, Melanoma, Wilms Tumor, Neuroblastoma, Pheochromocytoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Thyroid Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor

NCT07440290 2026-02-27

DETERMINE

Cancer Research UK

Phase 2/3 Not yet recruiting
30 enrolled
CNSEndocrineGastrointestinalGynecologicHead & NeckLymphoidMyeloidOther hematologic neoplasmPlasma cellThoracic

Thyroid Cancer, Papillary, Carcinoma, Non-Small-Cell Lung, Gastrointestinal Neoplasms, Glioma, Histiocytosis, Langerhans-Cell, Laryngeal Neoplasms, Lymphoproliferative Disorders, Multiple Myeloma, Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Ovarian Neoplasms, Colorectal Neoplasms, Hematologic Neoplasms, Erdheim-Chester Disease, Thyroid Carcinoma, Anaplastic

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