Clinical Trials Browser

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Carcinoma, Squamous Cell, DNA Virus Infections, Head and Neck Neoplasms, Neoplasms by Histologic Type, Neoplasms by Site, Neoplasms, Glandular and Epithelial, Oropharyngeal Neoplasms, Otorhinolaryngologic Diseases, Otorhinolaryngologic Neoplasms, Pharyngeal Diseases, Tumor Virus Infections, Virus Diseases, Neoplasms, Squamous Cell, Papillomavirus Infections

NCT06362421 2025-07-31

Saliva Testing for High-Risk Human Papillomavirus Infection Oral Cavity and Pharynx Cancer

Withdrawn

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT05592626 2025-07-09

START-001

Phase 1/2 Recruiting

365 enrolled

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

Abdominal Neoplasms, Biliary Tract Neoplasms, Urinary Bladder Neoplasms, Carcinoma, Carcinoma, Basal Cell, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Genital Neoplasms, Female, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Nasopharyngeal Neoplasms, Neoplasms, Neoplasms by Site, Stomach Neoplasms, Urogenital Neoplasms, Vulvar Diseases, Vulvar Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Endometrial Neoplasms, Epstein-Barr Virus Infections, Papillomavirus Infections, Microsatellite Instability, Small Cell Lung Carcinoma

NCT07036211 2025-06-25

TREVINO

Not yet recruiting

700 enrolled

GynecologicHead & Neck

Uterine Cervical Neoplasms, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT05388773 2025-06-19

Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer

Phase 2 Recruiting

150 enrolled

Head & Neck

Carcinoma, Squamous Cell, DNA Virus Infections, Head and Neck Neoplasms, Stomatognathic Diseases, Neoplasms, Glandular and Epithelial, Oropharyngeal Neoplasms, Otorhinolaryngologic Diseases, Otorhinolaryngologic Neoplasms, Papilloma, Pharyngeal Diseases, Pharyngeal Neoplasms, Tumor Virus Infections, Papillomavirus Infections

NCT04965792 2025-06-17

Post-treatment Surveillance in HPV+ Oropharyngeal SCC

Active not recruiting

150 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT06055868 2025-05-28

People Living With HIV, Oral and Oropharyngeal Cancer, and Health Equity

Recruiting

144 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Coitus, HIV Infections, Papillomavirus Infections

NCT02827838 2025-03-17

Durvalumab Before Surgery in Treating Patients With Oral Cavity or Oropharynx Cancer

Phase EARLY_PHASE1 Terminated

17 enrolled 12 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT06797986 2025-01-29

A Phase I/IIa Clinical Trial to Investigate BVAC-E6E7 in Subjects with HPV Positive HNSCC.

Phase 1/2 Not yet recruiting

37 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT02258659 2024-09-24

OPTIMA

Phase 2 Completed

62 enrolled 13 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT05918510 2023-10-10

Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus

Recruiting

142 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Lymphatic Metastasis, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT01084083 2023-06-28

Induction Chemotherapy Followed By Cetuximab and Radiation in HPV-Associated Resectable Stage III/IV Oropharynx Cancer

Phase 2 Completed

90 enrolled 7 charts

Head & NeckOther neoplasm

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Precancerous Conditions, Tongue Neoplasms, Papillomavirus Infections

NCT03258008 2022-12-16

Utomilumab and ISA101b Vaccination in Patients With HPV-16-Positive Incurable Oropharyngeal Cancer

Phase 2 Terminated

3 enrolled 7 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Oropharyngeal Neoplasms, Papillomavirus Infections

NCT01891695 2022-10-12

OPSCC N0 Nodal Control With Reduced IMRT

Phase NA Terminated

1 enrolled 4 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT04015336 2022-02-24

E7 TCR Cell Induction Immunotherapy for Stage II and Stage III HPV-Associated Oropharyngeal Cancer

Phase 2 Terminated

1 enrolled 6 charts

Head & Neck

Oropharyngeal Neoplasms, Papillomavirus Infections

NCT02981862 2021-08-31

CaptHPV

Phase NA Completed

100 enrolled

GastrointestinalGenitourinaryGynecologicHead & Neck

Anus Neoplasms, Uterine Cervical Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Penile Neoplasms, Vulvar Neoplasms, Papillomavirus Infections

NCT04044950 2020-09-22

A Phase II Study of Neoadjuvant E7 TCR T Cell Immunotherapy for Borderline Resectable and Unresectable Stage I HPV-Associated Oropharyngeal Cancer

Phase 2 Withdrawn

Head & Neck

Oropharyngeal Neoplasms, Papillomavirus Infections

NCT03346915 2019-10-09

Integrating a Health Information Technology System for Primary and Secondary Cervical Cancer Prevention

Phase NA Completed

60 enrolled

GastrointestinalGenitourinaryGynecologicHead & Neck

Anus Neoplasms, Uterine Cervical Neoplasms, Oropharyngeal Neoplasms, Penile Neoplasms, Vaginal Neoplasms, Vulvar Neoplasms, Papillomavirus Infections

NCT02706691 2019-04-16

BGJ398 in Treating Patients With FGFR Positive Recurrent Head and Neck Cancer

Phase 2 Terminated

1 enrolled 8 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Neoplasms, Papillomavirus Infections

NCT00897273 2019-01-17

Oral HPV Infection in Young Men

Completed

500 enrolled

Head & NeckOther neoplasm

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Infections, Oropharyngeal Neoplasms, Precancerous Conditions, Papillomavirus Infections

NCT01958515 2018-11-06

Immunologic Responses in HPV-Associated Carcinoma for Patients Receiving Chemoradiation

Completed

20 enrolled

Head & Neck

Head and Neck Neoplasms, Papillomavirus Infections

NCT02048020 2018-08-14

Paclitaxel and Carboplatin Before Radiation Therapy With Paclitaxel in Treating HPV-Positive Patients With Stage III-IV Oropharynx, Hypopharynx, or Larynx Cancer

Phase 2 Completed

26 enrolled

Head & Neck

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT01585428 2018-03-07

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated Cancers

Phase 2 Completed

29 enrolled 12 charts

GastrointestinalGenitourinaryGynecologicHead & Neck

Anus Neoplasms, Uterine Cervical Neoplasms, Oropharyngeal Neoplasms, Penile Neoplasms, Vaginal Neoplasms, Papillomavirus Infections

NCT00508170 2012-07-30

Sexual Behavior in Oropharyngeal Patients Versus Head and Neck Cancer Patients, With or Without HPV Infection

Completed

252 enrolled

Head & Neck

Head and Neck Neoplasms, Oropharyngeal Neoplasms, Sexual Behavior, Papillomavirus Infections

Clinical Trials

(NeoScorch HN)

Transoral Surgery Followed By Low-Dose or Standard-Dose Radiation Therapy With or Without Chemotherapy in Treating Patients With HPV Positive Stage III-IVA Oropharyngeal Cancer

Extended Follow Up of Young Women in Costa Rica Who Received Vaccine for Human Papillomavirus Types 16 and 18 and Unvaccinated Controls

SAVED

Prevalence of Human Papillomavirus (HPV) in a Healthy Population: A Feasibility Study of Oropharyngeal Cancer Screening

Role of Liquid Biopsies in HPV-associated Cancer Treatment Monitoring

Radiation Therapy and Docetaxel in Treating Patients With HPV-Related Oropharyngeal Cancer

Radiation Therapy With Cisplatin or Cetuximab in Treating Patients With Oropharyngeal Cancer

QoLATI

Saliva Testing for High-Risk Human Papillomavirus Infection Oral Cavity and Pharynx Cancer

START-001

TREVINO

Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer

Post-treatment Surveillance in HPV+ Oropharyngeal SCC

People Living With HIV, Oral and Oropharyngeal Cancer, and Health Equity

Durvalumab Before Surgery in Treating Patients With Oral Cavity or Oropharynx Cancer

A Phase I/IIa Clinical Trial to Investigate BVAC-E6E7 in Subjects with HPV Positive HNSCC.

OPTIMA

Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus

Induction Chemotherapy Followed By Cetuximab and Radiation in HPV-Associated Resectable Stage III/IV Oropharynx Cancer

Utomilumab and ISA101b Vaccination in Patients With HPV-16-Positive Incurable Oropharyngeal Cancer

OPSCC N0 Nodal Control With Reduced IMRT

E7 TCR Cell Induction Immunotherapy for Stage II and Stage III HPV-Associated Oropharyngeal Cancer

CaptHPV

A Phase II Study of Neoadjuvant E7 TCR T Cell Immunotherapy for Borderline Resectable and Unresectable Stage I HPV-Associated Oropharyngeal Cancer

Integrating a Health Information Technology System for Primary and Secondary Cervical Cancer Prevention

BGJ398 in Treating Patients With FGFR Positive Recurrent Head and Neck Cancer

Oral HPV Infection in Young Men

Immunologic Responses in HPV-Associated Carcinoma for Patients Receiving Chemoradiation

Paclitaxel and Carboplatin Before Radiation Therapy With Paclitaxel in Treating HPV-Positive Patients With Stage III-IV Oropharynx, Hypopharynx, or Larynx Cancer

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Human Papillomavirus-Associated Cancers

Sexual Behavior in Oropharyngeal Patients Versus Head and Neck Cancer Patients, With or Without HPV Infection