Clinical Trials Browser

Metformin × Head & Neck × 1 year × Clear all

Squamous Cell Carcinoma of Head and Neck, Breast Diseases, Breast Neoplasms, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Neoplasms, Neoplasms by Site, Hereditary Sensory and Autonomic Neuropathies, Ovarian Neoplasms, Endometrial Neoplasms

NCT04414540 2026-05-08

Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients

Phase 2 Active not recruiting

21 enrolled 12 charts

Head & Neck

Squamous Cell Carcinoma of Head and Neck

NCT04114136 2026-04-24

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Phase 2 Recruiting

72 enrolled

DermatologicGastrointestinalHead & Neck

Adenocarcinoma Of Esophagus, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hepatocellular, Melanoma

NCT05237960 2026-04-20

Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia

Phase 2 Active not recruiting

34 enrolled

Head & Neck

Erythroplasia, Leukoplakia, Oral

NCT02581137 2026-04-13

Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion

Phase 2 Active not recruiting

26 enrolled 10 charts

Head & Neck

Erythroplasia, Hyperplasia, Leukoplakia, Oral, Mouth Neoplasms

NCT07387900 2026-02-06

Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia

Phase 2 Recruiting

34 enrolled

Head & Neck

Leukoplakia, Oral

NCT03109847 2025-12-11

Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers

Phase 2 Terminated

13 enrolled 8 charts

Head & Neck

Thyroid Diseases

Clinical Trials

PIKALO-1

Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia

Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion

Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia

Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers