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NCT05110781 2026-06-05

Atezolizumab Before Surgery for the Treatment of Regionally Metastatic Head and Neck Squamous Cell Cancer With an Unknown or Historic Primary Site

Phase 2 Terminated

1 enrolled 9 charts

DermatologicHead & Neck

Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck

NCT03132922 2026-06-04

MAGE-A4ᶜ¹º³²T for Multi-Tumor

Phase 1 Active not recruiting

71 enrolled 20 charts

DermatologicGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

Adenocarcinoma, Urinary Bladder Neoplasms, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Head and Neck Neoplasms, Melanoma, Neoplasm Metastasis, Ovarian Neoplasms, Sarcoma, Stomach Neoplasms, Sarcoma, Synovial, Liposarcoma, Myxoid

NCT02567422 2026-06-02

Testing the Addition of M6620 (VX-970, Berzosertib) to Usual Chemotherapy and Radiation for Head and Neck Cancer

Phase 1 Active not recruiting

43 enrolled 16 charts

Squamous Cell Carcinoma of Head and Neck

NCT03822897 2026-02-17

EVADER

Phase 2 Active not recruiting

103 enrolled 11 charts

Oropharyngeal Neoplasms

NCT05245682 2026-01-08

Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer

Phase EARLY_PHASE1 Active not recruiting

10 enrolled 8 charts

Head & NeckOther solid neoplasm

Head and Neck Carcinoma of Unknown Primary

NCT02586207 2025-10-07

Pembrolizumab in Combination With CRT for LA-SCCHN

Phase 1 Completed

59 enrolled 9 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Diseases, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT03944915 2025-05-11

DEPEND

Phase 2 Completed

35 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT03085719 2025-02-25

Targeting PD-1 Therapy Resistance With Focused High or High and Low Dose Radiation in SCCHN

Phase 2 Active not recruiting

18 enrolled 22 charts

Head and Neck Neoplasms

NCT02258659 2024-09-24

OPTIMA

Phase 2 Completed

62 enrolled 13 charts

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT04541355 2024-06-28

Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With Cisplatin

Phase 2 Completed

16 enrolled 12 charts

Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT01711541 2023-06-07

Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IV Head and Neck Cancer

Phase 1/2 Completed

24 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck, Oropharyngeal Neoplasms

NCT00274937 2022-10-25

Radiation Therapy, Amifostine, and Chemotherapy in Treating Young Patients With Newly Diagnosed Nasopharyngeal Cancer

Phase 3 Completed

111 enrolled 11 charts

Stage I Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7

NCT00736944 2020-09-09

Trial of 2 Cycles of Induction Chemo With Abraxane, Cetuximab, Cisplatin, & 5-FU for Advanced Head and Neck Cancer

Phase 2 Completed

30 enrolled 26 charts

Squamous Cell Carcinoma of Head and Neck

NCT00608205 2020-08-06

Radiation Therapy Cisplatin With or Without Fluorouracil Patients With Stage III or Stage IV Head and Neck Cancer

Phase 3 Completed

69 enrolled 47 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT00343083 2019-08-19

Evaluation of Cetuximab (ERBITUX) and Concurrent Carboplatin, Paclitaxel & Radiotherapy in the Management of Patients With Advanced Locoregional Squamous Cell Carcinomas of the Head and Neck (GCC 0442)

Phase 2 Completed

43 enrolled 11 charts

Head and Neck Neoplasms

NCT00256308 2018-05-01

Adjuvant Chemoradiation With Weekly Oxaliplatin in Resected Head and Neck Cancer

Phase 2 Terminated

6 enrolled 11 charts

Head and Neck Neoplasms

NCT00352118 2017-12-28

Combination Chemotherapy and Radiation Therapy in Treating Patients With Locally Advanced Head and Neck Cancer

Phase 2 Terminated

4 enrolled 4 charts

Head & NeckOther

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Xerostomia, Mucositis

NCT00490061 2017-03-06

Lapatinib and Radiation for Stage III-IV Head and Neck Cancer Patients Who Cannot Tolerate Concurrent Chemotherapy

Phase 2 Terminated

17 enrolled 7 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT01161498 2016-02-08

Study of Safety and Efficacy of Talimogene Laherparepvec With Cisplatin and Radiotherapy for Treatment of Locally Advanced Head and Neck Cancer

Phase 3 Terminated

5 enrolled 8 charts

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT01790516 2014-10-02

Use of Pharmacogenetics to Select Erbitux or Cisplatin to Treat Head and Neck Cancer

Phase NA Terminated

2 enrolled 7 charts

Head and Neck Neoplasms

NCT01682031 2014-08-22

Selenomethionine in Reducing Mucositis in Patients With Locally Advanced Head and Neck Cancer Who Are Receiving Cisplatin and Radiation Therapy

Phase 2 Terminated

18 enrolled 8 charts

Head & NeckOther

Squamous Cell Carcinoma of Head and Neck, Radiation Injuries, Xerostomia, Mucositis