Announcements Trials
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Phase

Phase 3 4Phase 2 1

Status

Completed 3Terminated 2

Sponsor Class

OTHER 17INDUSTRY 5NETWORK 3NIH 1

Study Type

Interventional 5

Sponsor

Cancer Type

Thoracic 41Tumor-Agnostic 18Breast 9Head & Neck 5Gastrointestinal 4Genitourinary 3Sarcoma 2Other solid neoplasm 2CNS 2

Conditions

Head and Neck Neoplasms 5Carcinoma, Squamous Cell 2

Interventions

pembrolizumab 166Cisplatin 112Cetuximab 76Nivolumab 52Carboplatin 51Fluorouracil 48Paclitaxel 42Docetaxel 37Gemcitabine 30Radiotherapy 28Capecitabine 19Cyclophosphamide 18durvalumab 17Injections 17lenvatinib 16atezolizumab 16cemiplimab 15spartalizumab 13fludarabine 13avelumab 12Ipilimumab 12Pemetrexed 11130-nm albumin-bound paclitaxel 11Oxaliplatin 10Gefitinib 10tremelimumab 9Drug Therapy 9tislelizumab 8epacadostat 8budigalimab 8

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
INDUSTRY × Afatinib × Head & Neck × Clear all
NCT01856478 2026-01-12

LUX-Head&Neck 3: Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy

Boehringer Ingelheim

Phase 3 Completed
340 enrolled 23 charts
Head & Neck

Head and Neck Neoplasms

NCT02131155 2019-03-01

LUX-Head & Neck 4: Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy

Boehringer Ingelheim

Phase 3 Terminated
36 enrolled 6 charts
Head & Neck

Head and Neck Neoplasms

NCT01345682 2018-02-15

LUX-Head&Neck 1: A Phase III Trial of Afatinib (BIBW2992) Versus Methotrexate for the Treatment of Recurrent and/or Metastatic (R/M) Head and Neck Squamous Cell Cancer After Platinum Based Chemotherapy

Boehringer Ingelheim

Phase 3 Completed
483 enrolled 21 charts
Head & Neck

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT01345669 2017-12-07

LUX-Head&Neck 2: A Phase III Trial of Afatinib (BIBW 2992) Versus Placebo for the Treatment of Head and Neck Squamous Cell Cancer After Treatment With Chemo-radiotherapy

Boehringer Ingelheim

Phase 3 Terminated
617 enrolled 13 charts
Head & Neck

Head and Neck Neoplasms

NCT00514943 2016-07-26

BIBW 2992 (Afatinib) in Head & Neck Cancer

Boehringer Ingelheim

Phase 2 Completed
124 enrolled 31 charts
Head & Neck

Carcinoma, Squamous Cell, Head and Neck Neoplasms

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