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Phase

Phase 2 6Phase EARLY_PHASE1 4Phase NA 3Phase 4 2Phase 3 2Phase 1/2 2Phase 1 2

Status

Terminated 1Completed 1

Sponsor Class

OTHER 2

Study Type

Interventional 2

Sponsor

Cancer Type

Gastrointestinal 6Tumor-Agnostic 5Breast 5Other solid neoplasm 4Other hematologic neoplasm 4Genitourinary 4Lymphoid 3Gynecologic 3CNS 3Plasma cell 2Other 2Head & Neck 2Dermatologic 2Thoracic 1Sarcoma 1Classical hematology 1

Conditions

Mouth Neoplasms 1Leukoplakia 1Head and Neck Neoplasms 1Erythroplasia 1

Interventions

pembrolizumab 84Cisplatin 73Cetuximab 54Radiotherapy 41Nivolumab 31Radiotherapy, Intensity-Modulated 26Docetaxel 26Fluorouracil 23Cyclophosphamide 23Paclitaxel 22fludarabine 19Radiation 18Gemcitabine 18Carboplatin 18Magnetic Resonance Spectroscopy 16Erlotinib Hydrochloride 16durvalumab 15atezolizumab 13fludarabine phosphate 10Radiosurgery 10Specimen Handling 9Interleukin-2 9Drug Therapy 9Biopsy 9130-nm albumin-bound paclitaxel 9budigalimab 8Ipilimumab 8Bortezomib 8tremelimumab 7toripalimab 7

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Phase 1 × Metformin × Head & Neck × Clear all
NCT05536037 2025-05-15

Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions

Thomas Jefferson University

Phase 1 Terminated
4 enrolled
Head & Neck

Erythroplasia, Leukoplakia, Mouth Neoplasms

NCT02325401 2020-06-11

Dose-finding Study of Metformin With Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma

University of Cincinnati

Phase 1 Completed
20 enrolled 11 charts
Head & Neck

Head and Neck Neoplasms

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