Clinical Trials
21 trialsNCT05768139 2026-06-04
PIKALO-1
Eli Lilly and Company
Phase 1/2 Recruiting
NCT04414540 2026-05-08
Combining Pembrolizumab and Metformin in Metastatic Head and Neck Cancer Patients
University of Cincinnati
Phase 2 Active not recruiting
NCT04114136 2026-04-24
Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies
University of Pittsburgh
Phase 2 Recruiting
NCT05237960 2026-04-20
Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia
University of Arizona
Phase 2 Active not recruiting
NCT02581137 2026-04-13
Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion
National Cancer Institute (NCI)
Phase 2 Active not recruiting
NCT07387900 2026-02-06
Evaluation of the Chemo-preventive Effect of Combined Topical and Systemic Metformin on Oral Leukoplakia
Cairo University
Phase 2 Recruiting
NCT03109847 2025-12-11
Metformin to Mitigate Sequelae of Radioactive Iodine Treatment for Thyroid Cancers
Thomas Jefferson University
Phase 2 Terminated
NCT02083692 2025-05-15
Pilot Study of Metformin in Head and Neck Squamous Cell Cancer and Its Effects on Stromal-epithelial Metabolic Uncoupling
Thomas Jefferson University
Phase EARLY_PHASE1 Completed
NCT03618654 2025-05-15
Durvalumab With or Without Metformin in Treating Participants With Head and Neck Squamous Cell Carcinoma
Thomas Jefferson University
Phase EARLY_PHASE1 Completed
NCT05536037 2025-05-15
Metformin for the Prevention of Oral Cancer in Patients With Oral Premalignant Lesions
Thomas Jefferson University
Phase 1 Terminated
NCT03109873 2025-04-30
Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer
Thomas Jefferson University
Phase EARLY_PHASE1 Completed
NCT02949700 2023-06-29
Phase I/II Study OF Metformin in Combination With Cisplatin and Radiation in Head and Neck Squamous Cell Carcinoma
Baylor College of Medicine
Phase 1/2 Completed
NCT05468554 2022-10-19
METHYR
Medical University of Bialystok
Phase 3 Unknown
NCT03510390 2021-11-18
HEAD-MET
Insel Gruppe AG, University Hospital Bern
Phase NA Completed
NCT04298684 2020-09-11
METNODTHYR
Centre Hospitalier Universitaire de la Guadeloupe
Phase 4 Unknown
NCT02325401 2020-06-11
Dose-finding Study of Metformin With Chemoradiation in Locally Advanced Head and Neck Squamous Cell Carcinoma
University of Cincinnati
Phase 1 Completed
NCT03183752 2019-04-19
Insulin Resistance and Metformin Use on Volume of Benign Thyroid Nodules
Hospital Universitário Clementino Fraga Filho
Phase NA Completed
NCT03684707 2018-09-26
Cancer Chemoprevention by Metformin Hydrochloride Compared to Placebo in Oral Potentially Malignant Lesions
Ain Shams University
Phase 4 Unknown
NCT03685409 2018-09-26
Cancer Chemoprevention by Metformin Hydrochloride in Oral Potentially Malignant Lesions
Cairo University
Phase 3 Unknown
NCT02402348 2017-02-08
Pilot Study of Metformin in HNSCC to Investigate the Effects of MF, Tumor Genotype and MF-genotype Interactions, on Tumor Metabolism and Anoikis
West Virginia University
Phase EARLY_PHASE1 Terminated
NCT01341886 2011-04-26
Effect of Metformin on Decrement in Levothyroxin Dose Required for Thyroid Stimulating Hormone (TSH) Suppression in Patients With Differentiated Thyroid Cancer
Mashhad University of Medical Sciences
Phase NA Completed