Clinical Trials Browser

Recruiting × Radiotherapy × Head & Neck × Clear all

NCT06702033 2026-04-16

MINT-2

Phase 2 Recruiting

Oropharyngeal Neoplasms

NCT05172245 2026-04-13

Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer

Phase 1 Recruiting

Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT06064097 2026-04-13

A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

Phase 2 Recruiting

Nasopharyngeal Carcinoma

NCT07195734 2026-04-13

Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

Phase 2 Recruiting

Carcinoma, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07423078 2026-04-13

WOLF

Phase 2 Recruiting

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis, Recurrence

NCT06992427 2026-04-07

HOPE

Phase 3 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07201337 2026-04-06

Reduced-dose vs Standard-dose Irradiation for Low-risk Clinical Target Volume in Nasopharyngeal Carcinoma.

Phase 3 Recruiting

Nasopharyngeal Carcinoma

NCT07353671 2026-03-25

Topical Periplaneta Americana-Derived Meilian Fuxin Liquid for Radiation Dermatitis

Phase 2/3 Recruiting

Head and Neck Neoplasms, Radiodermatitis

NCT06554158 2026-03-23

De-escalation of Adjuvant Radiation for Low-Risk HPV Oropharyngeal Cancers

Phase NA Recruiting

Oropharyngeal Neoplasms

NCT05941741 2026-03-18

IC Plus Low-dose Radiation Plus Cadonilimab in LANPC

Phase 3 Recruiting

Nasopharyngeal Carcinoma

NCT03875716 2026-03-13

Study of De_Intensified Postoperative Radiation Therapy for HPV Associated Oropharyngeal Squamous Cell Carcinoma

Phase NA Recruiting

Head and Neck Neoplasms

NCT04892173 2026-03-13

JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC

Phase 3 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT04075305 2026-03-05

MOMENTUM

BreastCNSGastrointestinalGenitourinaryHead & NeckThoracic

Urinary Bladder Neoplasms, Brain Neoplasms, Breast Neoplasms, Esophageal Neoplasms, Genital Neoplasms, Female, Head and Neck Neoplasms, Liver Neoplasms, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Radiation Injuries, Rectal Neoplasms

NCT06208826 2026-03-03

A Single-center Phase II Study to Investigate the Immune Maintenance Therapy Pattern in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma Who Have Achieved MPR After Neoadjuvant Immunotherapy Combined With Chemotherapy

Phase 2 Recruiting

Head and Neck Neoplasms

NCT07026474 2026-03-02

RePaIr-HN

Phase 3 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT06558981 2026-02-27

Adjuvant Radiotherapy in High Risk Locally Advanced DTC

Phase 3 Recruiting

Thyroid Neoplasms

NCT07044635 2026-02-27

RAD RAPTORS

Phase 2 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT05268614 2026-02-18

Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma

Phase 2 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT05962242 2026-02-05

HN001

Phase 2 Recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04754321 2026-02-02

Combining Immunotherapy Salvage Surgery & IORT Tx Persistent/Recurrent Head & Neck Cancer

Phase 1 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07371611 2026-01-28

Sintilimab Plus Chemotherapy as Neoadjuvant and Adjuvant Treatment for Locally Advanced Oral Squamous Cell Carcinoma

Phase 3 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07369882 2026-01-27

Comparison of Efficacy Between De-escalated Surgery and Standard Surgery After Neoadjuvant Immunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase NA Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07328841 2026-01-09

Reduced-dose Versus Conventional-dose Intensity-modulated Radiation Therapy for Locally Advanced Nasopharyngeal Carcinoma With Remission After Induction Chemotherapy and Immunotherapy

Phase 3 Recruiting

Nasopharyngeal Carcinoma, Pathologic Complete Response

NCT06998069 2025-12-30

Head and Neck Cancer Study Project in the Geriatric Population

Phase 3 Recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07040956 2025-12-29

A Clinical Trial Comparing Low-Dose RT + Targeted Therapy+ Immunotherapy vs Targeted Therapy+ Immunotherapy Alone as Neoadjuvant Therapy in Operable HNSCC Patients.

Phase 2 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT04908696 2025-12-04

Clinical Treatments in Specialized Diseases of Laryngeal Carcinoma (LC) and Hypopharyngeal Carcinoma (HPC)

Hypopharyngeal Neoplasms, Laryngeal Neoplasms

NCT07170358 2025-09-12

RIX

Head and Neck Neoplasms, Xerostomia

NCT07121595 2025-08-13

Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial

Phase 2 Recruiting

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT03649048 2025-07-31

RADIO

Phase NA Recruiting

Locally Advanced Head and Neck Squamous Cell Carcinoma

NCT04900623 2025-07-30

Risk-adapted Therapy in HPV+ Oropharyngeal Cancer Using Circulating Tumor (ct)HPV DNA Profile - The ReACT Study

Phase 2 Recruiting

Oropharyngeal Neoplasms

NCT04545957 2025-07-28

JUMP

Phase NA Recruiting

GastrointestinalGenitourinaryHead & Neck

Adenocarcinoma, Head and Neck Neoplasms, Liver Neoplasms, Prostatic Neoplasms

NCT07055841 2025-07-09

Single-Arm Exploratory Study of PD-L1 Antibody Plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase 2 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT06940180 2025-06-26

Toripalimab With Chemotherapy for Sinus Cancer

Phase 2 Recruiting

Sinonasal undifferentiated carcinoma, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Paranasal Sinus Neoplasms

NCT06494995 2025-06-04

AK104 and Low-dose Radiation in Recurrent/Metastatic HNSCC After Failure of First-line Systemic Therapy

Phase 2 Recruiting

Diabetes Mellitus, Insulin-Dependent, 12, Squamous Cell Carcinoma of Head and Neck

NCT06673693 2025-04-16

NEOSTART

Phase 2 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT05784012 2025-03-13

RADIAN

Phase 1/2 Recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Laryngeal Diseases, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05800574 2024-12-24

Lymphoscintigraphy Directed Elective Neck Radiation for p16+ Favorable Risk Oropharynx Cancer

Phase 2 Recruiting

Oropharyngeal Neoplasms

NCT06725498 2024-12-10

Intra-arterial Chemotherapy Combined with Radiotherapy and Immunotherapy for HNSCC

Phase 2 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT06700863 2024-11-22

RIX

Head and Neck Neoplasms, Xerostomia

NCT06688760 2024-11-14

Surgery Alone Verus Sugery Combined with Dose-reduced Radiotherapy for Newly Diagnosed Stage I Nasopharyngeal Carcinoma

Phase NA Recruiting

Nasopharyngeal Carcinoma

NCT06323239 2024-08-20

SBRT and LDRT Combined With PD-1 Antibody and Chemotherapy in r/m Nasopharyngeal Carcinoma

Phase 2 Recruiting

Nasopharyngeal Carcinoma

NCT05412849 2024-05-23

Radiation Field, Dose and Fractionation Related to Mandibular Complications

Head and Neck Neoplasms, Osteoradionecrosis

NCT06019130 2024-05-16

NPC-Nivo

Phase 2 Recruiting

Nasopharyngeal Carcinoma, Nasopharyngeal Neoplasms

NCT06151743 2024-04-30

Neoadjuvant PD-1 Inhibitor Combined With Cetuximab and Platinum in Resectable Locally Advanced Hypopharyngeal Carcinoma

Phase 2 Recruiting

Locally Advanced Hypopharyngeal Carcinoma

NCT02435576 2024-04-15

H&NTOX

10,000 enrolled

Head and Neck Neoplasms

NCT05872880 2023-05-24

TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma.

Squamous Cell Carcinoma of Head and Neck

NCT04019548 2023-05-10

SwallPEG

Phase 3 Recruiting

Oropharyngeal Neoplasms

NCT05674305 2023-01-10

Radiotherapy Alone Versus Concurrent Chemo-radiotherapy for Nasopharyngeal Carcincoma Patients With Undectable EBV DNA After One Cylce Neoadjuvant Chemotherpy

Phase 3 Recruiting

Nasopharyngeal Carcinoma

NCT05343325 2022-12-29

The Efficacy and Safety of Neoadjuvant Low-dose Radiotherapy Combined With Chemoimmunotherapy in Locally Advanced HNSCC

Phase 2 Recruiting

Squamous Cell Carcinoma of Head and Neck