Clinical Trials

Phase 3 Not yet recruiting

Thyroid Neoplasms

NCT07402538 2026-02-11

Surgery With or Without Neoadjuvant Treatment of SBRT Plus Chemoimmunotherapy in Resectable Locally Advanced Oral and HPV-unrelated Oropharyngeal Squamous Cell Carcinoma

184 enrolled

Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05894083 2026-02-02

A Phase II Study for p16+ Oropharyngeal Cancer PerSonalized De-escalation Treatment at University of MIchigan (CuSToMIze)

150 enrolled

Squamous Cell Carcinoma of Head and Neck, Oropharyngeal Neoplasms

NCT07371611 2026-01-28

Sintilimab Plus Chemotherapy as Neoadjuvant and Adjuvant Treatment for Locally Advanced Oral Squamous Cell Carcinoma

Phase 3 Recruiting

104 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06997094 2026-01-26

Decitabine in Combination With Standard of Care Therapy for the Treatment of Surgically Resectable HPV-Negative Head and Neck Cancer

Phase 1 Recruiting

24 enrolled

Human Papillomavirus-Negative Neck Squamous Cell Carcinoma

NCT02296684 2026-01-15

Immunotherapy With MK-3475 in Surgically Resectable Head and Neck Squamous Cell Carcinoma

67 enrolled 15 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05494190 2025-12-30

The Management of Metastatic Neck Nodes in N2/3 Hypopharyngeal Squamous Cell Carcinoma

111 enrolled

Hypopharyngeal Neoplasms

NCT07248956 2025-12-23

Neoadjuvant Chemotherapy Combined With Finotonlimab in the Treatment of Locally Advanced Hypopharyngeal Carcinoma

116 enrolled

Hypopharyngeal Neoplasms

NCT04908696 2025-12-04

Clinical Treatments in Specialized Diseases of Laryngeal Carcinoma (LC) and Hypopharyngeal Carcinoma (HPC)

Recruiting

1,000 enrolled

Hypopharyngeal Neoplasms, Laryngeal Neoplasms

NCT07094685 2025-11-25

SENIOR-HN

28 enrolled

DermatologicHead & Neck

Advanced Head and Neck Squamous Cell Carcinoma

NCT06222606 2025-10-06

Surgery for Thyroid Cancer With or Without Autofluorescence to Prevent Hypoparathyroidism

160 enrolled

Hypoparathyroidism, Thyroid Neoplasms

NCT07145931 2025-08-28

Neoadjuvant Immunochemotherapy and Postoperative Adjuvant Immunotherapy for Head and Neck Squamous Cell Carcinoma Invading the Skull Base

24 enrolled

Head and Neck Cancer Squamous Cell Carcinoma

NCT07055841 2025-07-09

Single-Arm Exploratory Study of PD-L1 Antibody Plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma

69 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT05272696 2025-07-01

Pembrolizumab and Induction Chemotherapy in Locally Advanced HNSCC

86 enrolled

Phase EARLY_PHASE1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT07028918 2025-06-19

NCLDR

35 enrolled

Acidemia, isovaleric, Squamous Cell Carcinoma of Head and Neck

NCT06912711 2025-05-21

TN Induction and Adjuvant Therapy for Resectable Local Recurrent Nasopharyngeal Carcinoma

70 enrolled

Phase 3 Not yet recruiting

Nasopharyngeal Carcinoma

NCT06957938 2025-05-08

Comparing Neoadjuvant Chemotherapy Combined With PD-1 Inhibitor Versus Neoadjuvant Chemotherapy in Locally Advanced Laryngeal and Hypopharyngeal Carcinoma

168 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms

NCT06958601 2025-05-06

Safety and Efficacy of Transoral Robotic Thyroidectomy Versus Traditional Open Thyroidectomy for Thyroid Cancer

Not yet recruiting

400 enrolled

Thyroid Neoplasms

NCT06737822 2025-03-04

SurVIC

Phase 3 Recruiting

346 enrolled

Head and Neck Neoplasms, Mouth Neoplasms

NCT03721757 2025-02-25

NICO

21 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT06494943 2025-02-25

Induction IBI110 and Sintilimab with Chemotherapy in LA HNSCC

Phase 1/2 Recruiting

27 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06814067 2025-02-07

Phase II Multi-centered Study of Perioperative Ivonescimab Versus Pembrolizumab Combined with Standard of Care (SOC) in Patients with Resectable, Locally Advanced Head and Neck Squamous Cell Carcinoma

80 enrolled

Phase NA Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT06796348 2025-01-28

Radiofrequency Ablation Versus Hemithyroidectomy of Small Thyroid Cancers

88 enrolled

Thyroid Neoplasms

NCT03343236 2024-12-13

Nutrition and Inflammation in Patients With Head and Neck Cancer

Active not recruiting

522 enrolled

Head and Neck Neoplasms, Inflammation, Radiation Injuries

NCT06638762 2024-10-15

Multi-Site Pathological Images-Guided ViT for Oral Squamous Cell Carcinoma Recurrence Prediction

Completed

1,325 enrolled

Head and Neck Neoplasms

NCT04498221 2024-09-19

LOOC

150 enrolled

Phase 2 Active not recruiting

Oropharyngeal Neoplasms

NCT05724329 2024-09-19

Neoadjuvant Tislelizumab in Combination With Dasatinib and Quercetin in Resectable HNSCC (COIS-01)

24 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06578871 2024-09-03

SUPERIOR

90 enrolled

Phase 2 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT02641093 2024-08-29

Phase II Trial of Adjuvant Cisplatin and Radiation With Pembrolizumab in Resected Head and Neck Squamous Cell Carcinoma

96 enrolled 12 charts

Head and Neck Neoplasms

NCT06530316 2024-08-02

RET Inhibitor for Neoadjuvant Therapy in Locally Advanced RET-altered Thyroid Cancer

Recruiting

48 enrolled

Thyroid Neoplasms

NCT03565536 2024-04-19

Nexavar for Neoadjuvant Treatment of Anaplastic Thyroid Cancer

18 enrolled

EndocrineHead & Neck

Thyroid Carcinoma, Anaplastic

NCT01588431 2024-02-14

Bevacizumab/Ph 2 for Locally Advanced Head and Neck Cancer

3 enrolled 7 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02285543 2023-11-22

A Phase II Trial of TPF Induction Chemotherapy in cN2 OSCC Patients

Phase 2 Terminated

10 enrolled

Carcinoma, Squamous Cell, Mouth Neoplasms

NCT06051838 2023-09-25

Prognostic Value of Tumor Deposits for Patients With Papillary Thyroid Carcinoma

Completed

541 enrolled

EndocrineHead & Neck

Thyroid Cancer, Papillary, Extranodal Extension, Lymphatic Metastasis

NCT06039631 2023-09-15

Neoadjuvant Chemoimmunotherapy Followed By Radiation Or Organ Preservation Surgery In Laryngeal/Hypopharyngeal Cancer

82 enrolled

Hypopharyngeal Neoplasms, Laryngeal Neoplasms

NCT05993858 2023-08-15

PC-1

33 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT00258310 2023-03-10

Ph II Long Term/Low Dose Xeloda in Head and Neck Squamous Cell Carcinoma After Surgery, Radiation & or Chemo

35 enrolled 7 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT01265849 2022-08-19

IT-MATTERS

Phase 3 Completed

928 enrolled 25 charts

Squamous Cell Carcinoma of Head and Neck

NCT05476965 2022-07-27

iCSDeR

Phase 2 Unknown

20 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT00470496 2022-07-25

Photodynamic Therapy Using HPPH in Treating Patients Undergoing Surgery for Primary or Recurrent Head and Neck Cancer

Phase 1 Completed

15 enrolled

CNSEndocrineHead & Neck

Squamous Cell Carcinoma of Head and Neck, Thyroid Cancer, Papillary, Salivary Gland Neoplasms, Thyroid Neoplasms, Adenocarcinoma, Follicular, Esthesioneuroblastoma, Olfactory

NCT05352321 2022-07-01

Surgery Plus Target-reduction Chemoradiotherapy vs Regular Chemoradiotherapy for Newly Diagnosed Resectable Nasopharyngeal Carcinoma

264 enrolled

Nasopharyngeal Carcinoma

NCT05390294 2022-05-25

Survival With Patients Treated With Salivary Gland Cancer

Completed

250 enrolled