Clinical Trials

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Mouth Neoplasms

NCT06856213 2026-06-04

ERBIOTAX

65 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06029270 2026-06-03

Testing the Addition of BMS-986016 (Relatlimab) to the Usual Immunotherapy After Initial Treatment for Recurrent or Metastatic Nasopharyngeal Cancer

156 enrolled

Nasopharyngeal Carcinoma

NCT06064097 2026-06-03

A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

Nasopharyngeal Carcinoma

NCT06959511 2026-06-03

Zanzalintinib for the Treatment of Advanced Thyroid Cancer Before Surgery

45 enrolled

Thyroid Neoplasms

NCT06563362 2026-06-01

DeEscO

120 enrolled

Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT06980038 2026-06-01

Testing Whether Cemiplimab (REGN2810) Plus CDX-1140 Given Prior to Surgery Are Better Than Cemiplimab (REGN2810) Alone in Patients With Stage III-IV Head and Neck Cancer

44 enrolled

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Laryngeal Neoplasms, Mouth Neoplasms

NCT07392580 2026-06-01

Intralesional Chemotherapy (IC): Cisplatin + Epinephrine

20 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06485778 2026-05-29

A Study of Radiation Therapy After Surgery in People With Oral Tongue Squamous Cell Carcinoma

24 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06535607 2026-05-26

eVOLVE-02

GastrointestinalGynecologicHead & Neck

257 enrolled

Squamous Cell Carcinoma of Head and Neck, Esophageal Squamous Cell Carcinoma, Uterine Cervical Neoplasms

NCT06998342 2026-05-26

MOHSAHRTSS

24 enrolled

Head and Neck Neoplasms

NCT05800574 2026-05-22

Lymphoscintigraphy Directed Elective Neck Radiation for p16+ Favorable Risk Oropharynx Cancer

22 enrolled

Oropharyngeal Neoplasms

NCT06953089 2026-05-22

DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors

DermatologicGastrointestinalGynecologicHead & NeckThoracic

450 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Hepatocellular, Melanoma, Ovarian Neoplasms

NCT06959641 2026-05-22

XL092 for the Treatment of Locally Advanced or Metastatic Radioiodine Refractory Differentiated Thyroid Cancer

33 enrolled

EndocrineHead & Neck

Thyroid Cancer, Papillary, Adenocarcinoma, Follicular

NCT07325539 2026-05-22

LIGHT

55 enrolled

Nasopharyngeal Carcinoma

NCT07601737 2026-05-22

Nimotuzumab Combined With PD-1 Inhibitors and Chemotherapy in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma

182 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT06448026 2026-05-20

Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity Squamous Cell Carcinoma (OCSCC).

17 enrolled

Mouth Neoplasms

NCT07513389 2026-05-20

Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)

36 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT07195734 2026-05-19

Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer

180 enrolled

Carcinoma, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT05904080 2026-05-18

Testing Nivolumab and Ipilimumab Immunotherapy With or Without the Targeted Drug Cabozantinib in Recurrent, Metastatic, or Incurable Nasopharyngeal Cancer

Nasopharyngeal Carcinoma

NCT07497607 2026-05-18

REDUCE-30

31 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT02734537 2026-05-15

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

189 enrolled

Lymphoid Interstitial Pneumonia, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms

NCT06172478 2026-05-15

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

BreastDermatologicGastrointestinalGenitourinaryGynecologicHead & NeckThoracic

740 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Esophageal Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Melanoma, Ovarian Neoplasms, Pancreatic Neoplasms, Prostatic Neoplasms, Stomach Neoplasms, Endometrial Neoplasms

NCT06702033 2026-05-15

MINT-2

142 enrolled

Oropharyngeal Neoplasms

NCT07172256 2026-05-13

CUE-101with Pembrolizumab for Locally Advanced HPV+HNSCCs

Squamous Cell Carcinoma of Head and Neck

NCT05420948 2026-05-12

A Study of Pembrolizumab in Combination With Chemotherapy for Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT05541016 2026-05-12

De-Escalated Adjuvant and Definitive Radiation Therapy Informed by DART 2.0 ctHPV-DNA

455 enrolled

Carcinoma, Oropharyngeal Neoplasms

NCT06852638 2026-05-12

CD70-targeted immunoPET Imaging of Malignant Cancers

GenitourinaryHead & NeckLymphoid

300 enrolled

Nasopharyngeal Carcinoma, Carcinoma, Renal Cell, Kidney Neoplasms, Lymphoma, Lymphoma, Follicular, Lymphoma, Large B-Cell, Diffuse, Lymphoma, Mantle-Cell

NCT07149207 2026-05-12

Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors

Margins of Excision, Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms

NCT07581821 2026-05-12

Sintilimab Combined With Anlotinib and Taxane-Based Chemotherap for Recurrent/Metastatic Nasopharyngeal Carcinoma

33 enrolled

Nasopharyngeal Carcinoma, Neoplasm Metastasis, Recurrence

NCT06323239 2026-05-11

SBRT and LDRT Combined With PD-1 Antibody and Chemotherapy in r/m Nasopharyngeal Carcinoma

148 enrolled

Nasopharyngeal Carcinoma

NCT06984861 2026-05-11

A Study of Reduced Radiation Therapy With Chemotherapy in People With HPV-Positive Throat Cancer

74 enrolled

Oropharyngeal Neoplasms

NCT06997068 2026-05-11

Methotrexate, Erlotinib, and Celecoxib for the Treatment of Recurrent/Metastatic Head and Neck Cancer in a Rural Midwest United States Population

25 enrolled

Carcinoma, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms

NCT07572864 2026-05-11

Neoadjuvant ICI and Mitochondrial Vaccine for Resectable HNSCC

9 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06445114 2026-05-08

Using CircuLating Tumor DNA to Risk Adapt Post-Operative Therapy for HPV-associated Oropharyngeal Cancer

Carcinoma, Oropharyngeal Neoplasms

NCT06475300 2026-05-06

A Study of BL-B01D1+PD-1 Monoclonal Antibody in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer, Nasopharyngeal Carcinoma and Other Solid Tumors

570 enrolled

Head & NeckThoracic

Nasopharyngeal Carcinoma, Carcinoma, Non-Small-Cell Lung

NCT06769698 2026-05-06

A Study to See if Giving Fianlimab and Cemiplimab Together is Better Than Cemiplimab Alone at Treating Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

120 enrolled

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis, Recurrence

NCT06794372 2026-05-06

FAPIHN

20 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07058805 2026-05-06

COMPORT

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04852328 2026-05-05

Three Schedules of CUE-101 Administered Before Surgery or Definitive Chemoradiation Therapy in HLA-A*0201 Positive Patients With Locally Advanced, HPV16-Positive Oropharyngeal Squamous-Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck

NCT05408845 2026-05-04

Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) or Trastuzumab Deruxtecan for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancers

146 enrolled

Salivary Gland Neoplasms

NCT06532279 2026-05-04

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

98 enrolled

Squamous Cell Carcinoma of Head and Neck, Nasopharyngeal Carcinoma, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Stomatitis

NCT07040956 2026-05-04

A Clinical Trial Comparing Low-Dose RT + Targeted Therapy+ Immunotherapy vs Targeted Therapy+ Immunotherapy Alone as Neoadjuvant Therapy in Operable HNSCC Patients.

98 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT05358548 2026-04-30

ATATcH Alternating Treatment Plans for Advanced Cancer

150 enrolled

Head & NeckThoracic

Head and Neck Neoplasms, Lung Neoplasms

NCT07408063 2026-04-29

BeeHive