Clinical Trials Browser

Phase EARLY_PHASE1 × Head & Neck × Clear all

NCT06308913 2026-05-26

Pembrolizumab, INCB081776, and Radiation Therapy for Head and Neck Squamous Cell Carcinoma

Phase EARLY_PHASE1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Neoplasm Metastasis

NCT01098955 2026-05-22

Smoking Cessation Treatment for Head & Neck Cancer Patients

Phase EARLY_PHASE1 Active not recruiting

Head and Neck Neoplasms, Neoplasms, Smoking Cessation

NCT04541108 2026-05-22

Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies

Phase EARLY_PHASE1 Active not recruiting

DermatologicHead & NeckLymphoidSarcoma

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Lymphoma, Melanoma, Sarcoma

NCT06819228 2026-05-08

Window Trial of Fluorescently Labeled Panitumumab (Panitumumab-IRDye800) in Head and Neck Cancer

Phase EARLY_PHASE1 Recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Laryngeal Diseases, Mouth Neoplasms, Tongue Neoplasms

NCT05816785 2026-04-22

Pilot Study of Imatinib Cetuximab Combo for H & N Cancer

Phase EARLY_PHASE1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02790853 2026-04-15

Multimodal Imaging for Surveillance in Patients With Oral Potentially Malignant Disorders

Phase EARLY_PHASE1 Active not recruiting

Mouth Diseases, Mouth Neoplasms

NCT05587543 2026-04-02

Clinical Study on the EBV CAR-T /TCR-T Cells in the Treatment of Nasopharyngeal Carcinoma

Phase EARLY_PHASE1 Recruiting

Nasopharyngeal Carcinoma

NCT04188665 2026-03-20

Using MASL to Combat Oral Cancer

Phase EARLY_PHASE1 Completed

18 enrolled 8 charts

Squamous Cell Carcinoma of Head and Neck

NCT07459283 2026-03-10

The Safety, Dosimetry and Efficacy of 177Lu-INN805 in Patients With Malignant Solid Tumors

Phase EARLY_PHASE1 Not yet recruiting

BreastHead & NeckSarcoma

Breast Neoplasms, Head and Neck Neoplasms, Sarcoma, Thyroid Neoplasms

NCT07435415 2026-02-27

Local Injection Methylene Blue Combined With Radiation in HNSCC Patients

Phase EARLY_PHASE1 Active not recruiting

Head and Neck Neoplasms

NCT06305962 2026-02-19

177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors

Phase EARLY_PHASE1 Recruiting

BreastDermatologicGynecologicHead & NeckThoracic

Turcot syndrome, Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Melanoma, Endometrial Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT06639191 2026-01-30

AKIR001

Phase EARLY_PHASE1 Recruiting

EndocrineGynecologicHead & NeckThoracic

Carcinoma, Non-Small-Cell Lung, Uterine Cervical Neoplasms, Head and Neck Neoplasms, Vulvar Neoplasms, Thyroid Carcinoma, Anaplastic

NCT05553782 2026-01-26

Drug Screening Using Novel IMD in Salivary and Head and Neck Cancers

Phase EARLY_PHASE1 Recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Salivary Gland Neoplasms

NCT06579248 2026-01-14

Intraoral Hypothermia Device for Preserving Taste During Radiation

Phase EARLY_PHASE1 Recruiting

Head and Neck Neoplasms, Taste Disorders

NCT05245682 2026-01-08

Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer

Phase EARLY_PHASE1 Active not recruiting

10 enrolled 8 charts

Head & NeckOther solid neoplasm

Head and Neck Carcinoma of Unknown Primary

NCT06645808 2025-12-29

VARTUTRACE

Phase EARLY_PHASE1 Recruiting

BreastCNSGastrointestinalGenitourinaryHead & NeckSarcomaThoracic

Squamous Cell Carcinoma of Head and Neck, Urinary Bladder Neoplasms, Breast Neoplasms, Chondrosarcoma, Colonic Neoplasms, Esophageal Neoplasms, Glioblastoma, Lung Neoplasms, Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Sarcoma, Osteosarcoma, Stomach Neoplasms

NCT05183048 2025-12-26

Comparison of 89Zr Panitumumab and (18)F-Fluorodeoxyglucose to Identify Head and Neck Squamous Cell Carcinoma

Phase EARLY_PHASE1 Recruiting

Squamous Cell Carcinoma of Head and Neck

NCT05845307 2025-12-08

Randomized Pre-surgical Window-of-Opportunity Trial of TTI-101 in Patients With Stage II-IV Resectable HPV-negative Squamous Cell Carcinoma of the Head and Neck

Phase EARLY_PHASE1 Withdrawn

Squamous Cell Carcinoma of Head and Neck

NCT07218068 2025-11-03

IPDP

Phase EARLY_PHASE1 Completed

Dental Caries, Head and Neck Neoplasms, Stomatognathic Diseases, Osteoradionecrosis

NCT06914999 2025-10-22

Comparing an Investigational Scan (F-18 NaF PET/CT) to Standard of Care Imaging (F-18 FDG PET/CT) for Evaluating Vascular Complications in Patients Receiving Radiation Therapy for Head and Neck Cancer

Phase EARLY_PHASE1 Recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Oropharyngeal Neoplasms

NCT02467738 2025-09-19

Surgical Resection and Intraoperative Cesium-131 Brachytherapy for Head and Neck Cancer

Phase EARLY_PHASE1 Completed

Recurrent Head and Neck Carcinoma

NCT05403125 2025-09-17

SDF Application in Oral Cancer Patients to Prevent Dental Caries

Phase EARLY_PHASE1 Completed

Dental Caries, Pharyngeal Neoplasms, Xerostomia

NCT04630353 2025-09-12

A Study HB-201 in Patients With Newly Diagnosed HPV16+ Oropharynx or Locally Advanced Cervical Cancer

Phase EARLY_PHASE1 Terminated

GynecologicHead & Neck

Uterine Cervical Neoplasms, Oropharyngeal Neoplasms

NCT07168785 2025-09-11

[18F]-AraG PET Imaging in LA HNSCC

Phase EARLY_PHASE1 Not yet recruiting

Squamous Cell Carcinoma of Head and Neck

NCT05678348 2025-08-17

Pyrimethamine as an Inhibitor of NRF2 in HPV-unrelated Locally Advanced Head and Neck Squamous Cell Carcinoma

Phase EARLY_PHASE1 Completed

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT06273852 2025-08-11

A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors

Phase EARLY_PHASE1 Completed

BreastHead & Neck

Squamous Cell Carcinoma of Head and Neck, Triple Negative Breast Neoplasms

NCT06700070 2025-08-11

A Phase 0 Multicenter Study of the Pharmacodynamic Effects of Intratumoral Microdose Administration of PBA-0111 in Patients With Solid Tumors

Phase EARLY_PHASE1 Recruiting

BreastHead & Neck

Squamous Cell Carcinoma of Head and Neck, Triple Negative Breast Neoplasms

NCT07026981 2025-08-08

[Ga-68]MTP220 PET for Biodistribution and Efficacy in Pancreatic Cancer and Head and Neck Cancers

Phase EARLY_PHASE1 Not yet recruiting

GastrointestinalHead & Neck

Head and Neck Neoplasms, Pancreatic Neoplasms

NCT03215095 2025-07-17

RAI Plus Immunotherapy for Recurrent/Metastatic Thyroid Cancers

Phase EARLY_PHASE1 Active not recruiting

11 enrolled 6 charts

Thyroid Neoplasms

NCT06086925 2025-07-11

A Window of Opportunity Study of Black Raspberry for Patients With HNSCC

Phase EARLY_PHASE1 Withdrawn

Squamous Cell Carcinoma of Head and Neck

NCT03085056 2025-07-03

Trametinib in Combination With Paclitaxel in the Treatment of Anaplastic Thyroid Cancer

Phase EARLY_PHASE1 Active not recruiting

EndocrineHead & Neck

Thyroid Carcinoma, Anaplastic

NCT07028918 2025-06-19

NCLDR

Phase EARLY_PHASE1 Not yet recruiting

Acidemia, isovaleric, Squamous Cell Carcinoma of Head and Neck

NCT02145143 2025-06-18

Enhancing Radioiodine (RAI) Incorporation Into BRAF Mutant, RAI-Refractory Thyroid Cancers With the BRAF Inhibitor Vemurafenib: A Pilot Study

Phase EARLY_PHASE1 Completed

Thyroid Neoplasms, Heterotaxy Syndrome

NCT02083692 2025-05-15

Pilot Study of Metformin in Head and Neck Squamous Cell Cancer and Its Effects on Stromal-epithelial Metabolic Uncoupling

Phase EARLY_PHASE1 Completed

Head and Neck Squamous Cell Cancer

NCT03618654 2025-05-15

Durvalumab With or Without Metformin in Treating Participants With Head and Neck Squamous Cell Carcinoma

Phase EARLY_PHASE1 Completed

Squamous Cell Carcinoma of Head and Neck

NCT05278260 2025-05-14

Hydrogen-rich Water and Treatment of Mucositis Caused by Radiation Therapy in Head and Neck Cancer Patients

Phase EARLY_PHASE1 Completed

Head and Neck Neoplasms, Stomatitis

NCT03109873 2025-04-30

Metformin Hydrochloride in Affecting Cytokines and Exosomes in Patients With Head and Neck Cancer

Phase EARLY_PHASE1 Completed

9 enrolled 6 charts

Lymphoid Interstitial Pneumonia, Laryngeal Diseases

NCT03162731 2025-04-29

Nivolumab, Ipilimumab, and Radiation Therapy in Treating Patients With Stage III-IVB Head and Neck Cancer

Phase EARLY_PHASE1 Completed

Lymphoid Interstitial Pneumonia, Laryngeal Diseases

NCT06898437 2025-04-15

Study of 177Lu-LNC1004 Injection in FAP-positive Radioiodine-refractory Differentiated Thyroid Cancer

Phase EARLY_PHASE1 Recruiting

Thyroid Neoplasms

NCT05322135 2025-04-09

A Pilot Study of Glutamine PET Imaging of Head and Neck Squamous Cell Carcinoma

Phase EARLY_PHASE1 Terminated

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02827838 2025-03-17

Durvalumab Before Surgery in Treating Patients With Oral Cavity or Oropharynx Cancer

Phase EARLY_PHASE1 Terminated

17 enrolled 12 charts

Squamous Cell Carcinoma of Head and Neck, Papillomavirus Infections

NCT06806189 2025-02-03

Lipiodal Injection Technique for Free Flap Sparing Adjuvant RT Planning in HNC

Phase EARLY_PHASE1 Not yet recruiting

Head and Neck Neoplasms

NCT04883645 2025-01-28

Neoadjuvant Imiquimod Immunotherapy for Oral Cancer

Phase EARLY_PHASE1 Completed

16 enrolled 10 charts

Squamous Cell Carcinoma of Head and Neck

NCT06366451 2025-01-20

PBI-MST-01 (NCT04541108) Substudy AZN-05: Intratumoral Microdosing of Rilvegostomig, Volrustomig, Sabestomig, and AZD9592 in HNSCC

Phase EARLY_PHASE1 Recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03459729 2025-01-16

Pharmacokinetic (PK) Analysis of Antitumor B in Patients With Oral Cancer

Phase EARLY_PHASE1 Completed

6 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck

NCT06752473 2024-12-30

KSD-101 Therapy for Standard Treatment Failed EBV-associated Nasopharyngeal Carcinoma: an Exploratory Clinical Trial

Phase EARLY_PHASE1 Not yet recruiting

Nasopharyngeal Carcinoma

NCT04188951 2024-12-04

HFHS-1801-A Pilot Study of Immunotherapy As Consolidation Therapy for Patients with Recurrent Head and Neck Cancer

Phase EARLY_PHASE1 Completed

Head and Neck Neoplasms

NCT05996432 2024-09-23

Image-Based, In-Vivo Assessment of Tumor Hypoxia to Guide Hypoxia-Driven Adaptive Radiation Therapy

Phase EARLY_PHASE1 Recruiting

Squamous Cell Carcinoma of Head and Neck, Brain Neoplasms

NCT04085913 2024-07-29

Exparel Injection Effect on Postoperative Opioid Usage

Phase EARLY_PHASE1 Enrolling by invitation

Parathyroid Neoplasms, Thyroid Diseases

NCT06413095 2024-05-14

PBI-MST-01 (NCT04541108) Substudy MSD-03: Intratumoral Microdosing of Pembrolizumab Alone and With MK-0482 or MK-4830 in HNSCC or STS

Phase EARLY_PHASE1 Completed

Head & NeckSarcoma

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Sarcoma