Clinical Trials

Phase EARLY_PHASE1 Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Mouth Neoplasms

NCT01098955 2026-05-22

Smoking Cessation Treatment for Head & Neck Cancer Patients

51 enrolled

Head and Neck Neoplasms, Neoplasms, Smoking Cessation

NCT02254278 2026-05-22

Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer

Phase 2 Completed

316 enrolled 31 charts

Squamous Cell Carcinoma of Head and Neck, Tongue Neoplasms

NCT02308072 2026-05-22

ORCA-2

Phase 1 Completed

16 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT03336606 2026-05-22

Study of MEDI0562 Prior to Surgical Resection in Head and Neck Squamous Cell Carcinoma (HNSCC) or Melanoma

Phase 1 Completed

13 enrolled

DermatologicHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms, Melanoma, Neoplasms, Squamous Cell

NCT03449108 2026-05-22

LN-145 or LN-145-S1 in Treating Patients With Relapsed or Refractory Ovarian Cancer, Triple Negative Breast Cancer (TNBC), Anaplastic Thyroid Cancer, Osteosarcoma, or Other Bone and Soft Tissue Sarcomas

BreastEndocrineGynecologicHead & NeckSarcoma

30 enrolled

Bone Neoplasms, Ovarian Neoplasms, Sarcoma, Osteosarcoma, Giant Cell Tumor of Bone, Histiocytoma, Malignant Fibrous, Triple Negative Breast Neoplasms, Thyroid Carcinoma, Anaplastic

NCT03646461 2026-05-22

Trial of Ibrutinib Combined With Nivolumab or Cetuximab to Treat Recurrent/Metastatic HNSCC

Phase 2 Terminated

5 enrolled 9 charts

BreastHead & NeckLymphoid

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT03789097 2026-05-22

Vaccination With Flt3L, Radiation, and Poly-ICLC

Phase 1/2 Completed

17 enrolled

Squamous Cell Carcinoma of Head and Neck, Breast Neoplasms, Carcinoma, Lymphoma, Lymphoma, Non-Hodgkin

NCT04169074 2026-05-22

Immune Modulation by Abemaciclib in Head and Neck Squamous Cell Carcinoma (HNSCC). (AIM Trial)

Phase 2 Terminated

7 enrolled 14 charts

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Squamous Cell

NCT04265430 2026-05-22

Serial Magnetic Resonance Imaging for the Prediction of Radiation-Induced Changes in Normal Tissue of Patients With Oral Cavity or Skull Base Tumors

Phase 4 Recruiting

425 enrolled

Mouth Neoplasms, Osteoradionecrosis

NCT04589624 2026-05-22

An Investigational Scan (hpMRI) for Monitoring Treatment Response in Patients With Thyroid Cancer and Other Malignancies of the Head and Neck Undergoing Radiation Therapy and/or Systemic Therapy

Phase 1 Recruiting

42 enrolled

Thyroid Neoplasms

NCT04858269 2026-05-22

First Line Weekly Chemo/Immunotherapy for Metastatic Head/Neck Squamous Cell Carcinoma Patients

32 enrolled

Phase NA Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT05119036 2026-05-22

Adjuvant Treatment Deintensification After Transoral Surgery for Human Papillomavirus-Positive Squamous Cell Carcinoma

83 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT05198479 2026-05-22

SG-AAA-II-01

Phase 2 Suspended

25 enrolled

Nasopharyngeal Carcinoma, Nasopharyngeal Neoplasms

NCT05800574 2026-05-22

Lymphoscintigraphy Directed Elective Neck Radiation for p16+ Favorable Risk Oropharynx Cancer

22 enrolled

Oropharyngeal Neoplasms

NCT06959511 2026-05-22

Zanzalintinib for the Treatment of Advanced Thyroid Cancer Before Surgery

45 enrolled

Thyroid Neoplasms

NCT06959641 2026-05-22

XL092 for the Treatment of Locally Advanced or Metastatic Radioiodine Refractory Differentiated Thyroid Cancer

33 enrolled

EndocrineHead & Neck

Thyroid Cancer, Papillary, Adenocarcinoma, Follicular

NCT07325539 2026-05-22

LIGHT

55 enrolled

DermatologicGastrointestinalGenitourinaryHead & NeckThoracic

Nasopharyngeal Carcinoma

NCT07405086 2026-05-22

Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study

Phase 4 Recruiting

160 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Carcinoma, Renal Cell, Carcinoma, Hepatocellular, Lung Neoplasms, Melanoma, Neoplasm Metastasis

NCT07601737 2026-05-22

Nimotuzumab Combined With PD-1 Inhibitors and Chemotherapy in the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma

182 enrolled

Phase NA Active not recruiting

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT02253238 2026-05-20

Sensor-Assisted Prevention of Dehydration in Head and Neck Cancer Patients

427 enrolled

Dehydration, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Mouth Neoplasms, Nasopharyngeal Neoplasms, Oropharyngeal Neoplasms, Salivary Gland Neoplasms

NCT03494322 2026-05-20

EACH

Phase 2 Completed

16 enrolled

Carcinoma, Squamous Cell, Head and Neck Neoplasms

NCT04759911 2026-05-20

Selpercatinib Before Surgery for the Treatment of RET-Altered Thyroid Cancer

30 enrolled

EndocrineHead & Neck

Thyroid Cancer, Papillary, Thyroid Neoplasms, Carcinoma, Medullary, Thyroid Carcinoma, Anaplastic

NCT06054178 2026-05-20

Identification of Nerves Using Fluorescein Sodium

Phase 2 Completed

8 enrolled 9 charts

Head & NeckLymphoid

Adenolymphoma, Thyroid Diseases

NCT06448026 2026-05-20

Cemiplimab and Cetuximab Prior Salvage Surgery in Patients With Recurrent Oral Cavity Squamous Cell Carcinoma (OCSCC).

17 enrolled

Mouth Neoplasms

NCT06855212 2026-05-20

Phase II Study of Neoadjuvant Cetuximab and Cemiplimab in Patients Undergoing Surgery for HNSCC

22 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT07264075 2026-05-20

ILLUMINE

780 enrolled

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT07407582 2026-05-20

Ph. I/II Sodium Thiosulfate for OtoProtection During Cisplatin (STOP-CIS)

Phase 1/2 Recruiting

25 enrolled

GenitourinaryHead & Neck

Head and Neck Neoplasms, Neoplasms, Testicular Neoplasms, Hearing Loss

NCT07513389 2026-05-20

Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)

36 enrolled

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT07590024 2026-05-20

RAIRI-NPC

651 enrolled

Phase 4 Active not recruiting

Nasopharyngeal Carcinoma

NCT07600580 2026-05-20

The Association Between Bilateral Intermediate Cervical Plexus Block During Total Thyroidectomy and Surgical Stress Response

48 enrolled

Goiter, Thyroid Diseases, Thyroid Neoplasms

NCT00593840 2026-05-19

Phase II Trial Evaluating Elimination of Radiation Therapy

74 enrolled 10 charts

Laryngeal Neoplasms

NCT05787639 2026-05-19

Neoadjuvant Immunoradiotherapy With Evorpacept and Pembrolizumab in HPVOPC (Human Papilloma Virus Oropharynx Cancer)

29 enrolled

Phase NA Enrolling by invitation

Oropharyngeal Neoplasms

NCT07376837 2026-05-19

PTC-RFA

Phase NA Recruiting

30 enrolled

EndocrineHead & Neck

Thyroid Cancer, Papillary

NCT07595666 2026-05-19

Comparison of NeuroEXPLORER PET/CT Versus Standard-of-care PET/CT of the Head and Neck Region.

1,600 enrolled

CNSEndocrineHead & Neck

Amyotrophic Lateral Sclerosis, Brain Neoplasms, Dementia, Epilepsy, Head and Neck Neoplasms, Movement Disorders, Neuroblastoma, Parathyroid Neoplasms, Parkinson Disease, Pituitary Neoplasms, Lewy Body Disease

NCT06234748 2026-05-18

ARTHOUSE

19 enrolled

Oropharyngeal Neoplasms

NCT07497607 2026-05-18

REDUCE-30

31 enrolled

BreastCNSGenitourinaryHead & NeckLymphoidMyeloidSarcoma

Squamous Cell Carcinoma of Head and Neck

NCT01552434 2026-05-15

Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign Disease

Phase 1 Terminated

154 enrolled

Breast Neoplasms, Carcinoma, Transitional Cell, Endocrine Gland Neoplasms, Castleman Disease, Mouth Neoplasms, Neoplasm Metastasis, Neoplasms, Pharyngeal Neoplasms, Recurrence, Sarcoma, Soft Tissue Neoplasms, Thyroid Neoplasms, Urologic Neoplasms, Neurofibromatosis 2, Lymphangioleiomyomatosis, Neoplasms, Mesothelial, Erdheim-Chester Disease

NCT03650764 2026-05-15

Ramucirumab + Pembrolizumab in Patients With Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

Phase 1/2 Completed

43 enrolled

Squamous Cell Carcinoma of Head and Neck

NCT06277050 2026-05-15

Maintenance Therapy With Toripalimab and Capecitabine Versus Capecitabine Alone in High-risk Nasopharyngeal Carcinoma

264 enrolled

Nasopharyngeal Carcinoma

NCT06702033 2026-05-15

MINT-2

142 enrolled

Phase NA Not yet recruiting

Oropharyngeal Neoplasms

NCT07578727 2026-05-15

A Multicenter, Prospective, Phase III Clinical Study of Proton Intensity-modulated Radiotherapy Versus Photon Intensity-modulated Radiotherapy for Untreated Non-metastatic Nasopharyngeal Carcinoma

504 enrolled

Nasopharyngeal Carcinoma

NCT07580300 2026-05-15

PRORADNOR-RCT

400 enrolled