Clinical Trials

Head and Neck Neoplasms

NCT03953352 2026-04-15

GIRAFE

Head and Neck Neoplasms

NCT06098755 2026-02-04

The Sequestration of Holistic Stress Management Techniques for Adults

Classical hematologyHead & NeckOther

Brain Injuries, Traumatic, Occupational Stress, Anemia, Anemia, Sickle Cell, Anxiety Disorders, Arthritis, Arthritis, Rheumatoid, Depression, Escape Reaction, Fatigue, Flatfoot, Hemorrhoids, Hypertension, Hyperthyroidism, Immunologic Deficiency Syndromes, Erectile Dysfunction, Leiomyoma, Lordosis, Masturbation, Migraine Disorders, Priapism, Sickle Cell Trait, Stress Disorders, Post-Traumatic, Sexual Dysfunctions, Psychological, Migraine with Aura

NCT05850663 2026-02-03

Quality of Life Assessment of Radiotherapy in Recurrent Head and Neck Cancer

GynecologicHead & Neck

Uterine Cervical Neoplasms, Head and Neck Neoplasms, Endometrial Neoplasms

NCT06603155 2025-12-19

Time Restricted Eating (TRE) in Metastatic Head and Neck Squamous Cell Cancer (mHNSCC) or Unresectable or Metastatic Renal Cell Carcinoma (RCC)

GenitourinaryHead & Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell

NCT05668949 2025-12-17

Phase I/II Open Label Study Evaluating the Safety and Efficacy of Combining STAT3 Inhibition (TTI-101) With Anti-PD-1 Therapy (Pembrolizumab) in Patients With Recurrent or Metastatic (RM) Head and Neck Squamous Cell Carcinoma (HNSCC)

Phase EARLY_PHASE1 Withdrawn

Squamous Cell Carcinoma of Head and Neck

NCT05845307 2025-12-08

Randomized Pre-surgical Window-of-Opportunity Trial of TTI-101 in Patients With Stage II-IV Resectable HPV-negative Squamous Cell Carcinoma of the Head and Neck

Squamous Cell Carcinoma of Head and Neck

NCT04741256 2025-12-02

Implementation of a Standardized Tracheostomy Education Discharge Protocol

Head and Neck Neoplasms

NCT06804850 2025-11-19

Neoadjuvant Radiotherapy Plus Targeted Therapy and Immunotherapy vs. Targeted Therapy Plus Immunotherapy in Resectable HNSCC

Head and Neck Neoplasms

NCT05954676 2025-10-28

Online Peri-operative Education Program for Patients Undergoing Major Head & Neck Surgery

Head and Neck Neoplasms

NCT05754216 2025-10-01

Intraoperative Identification and Stimulation of the Glossopharyngeal Nerve

Head and Neck Neoplasms, Sleep Apnea, Obstructive

NCT01326468 2025-09-25

Torisel in Addition to Standard Chemotherapy With Radiation for Advanced Head and Neck Cancer

Head and Neck Neoplasms

NCT06276946 2025-09-05

Sparing Parotid Ducts Via MRI Sialography for Reduced Patient Reported Xerostomia

Head and Neck Neoplasms, Oropharyngeal Neoplasms, Xerostomia

NCT06347185 2025-07-17

SupCare

Phase EARLY_PHASE1 Withdrawn

Head and Neck Neoplasms

NCT06086925 2025-07-11

A Window of Opportunity Study of Black Raspberry for Patients With HNSCC

Squamous Cell Carcinoma of Head and Neck

NCT05879484 2025-07-10

Study of Front Line Pembrolizumab and Valemetostat in PD-L1 Positive, HPV-Negative Recurrent/Metastatic Squamous Cell Carcinoma (SCC) of the Head and Neck: The PANTHERAS

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Lung Neoplasms

NCT06513884 2025-06-22

A Study of HB-202/HB-201 With Pembrolizumab in Patients With HPV16+ Recurrent/Metastatic Oropharyngeal Cancer

Phase 2/3 Withdrawn

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Neoplasms, Squamous Cell

NCT04595981 2025-04-27

Chemo-embolization for Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT05608369 2025-04-04

HPV

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT01345084 2025-03-28

NICAP

Phase 3 Withdrawn

Carcinoma, Head and Neck Neoplasms

NCT05452408 2025-03-18

Antitumor-B KAC PK Study

Squamous Cell Carcinoma of Head and Neck

NCT05743270 2025-03-11

Study of RP3 in Combination With Nivolumab and Other Therapy in Patients With Locoregionally Advanced or Recurrent SCCHN

Squamous Cell Carcinoma of Head and Neck

NCT03169764 2025-02-24

QUILT-3.047: NANT Head and Neck Squamous Cell Carcinoma (HNSCC) Vaccine: Combination Immunotherapy in Subjects With HNSCC Who Have Progressed on or After Chemotherapy and PD-1/PD-L1 Therapy

Squamous Cell Carcinoma of Head and Neck

NCT04977271 2025-02-04

Mood Disorders in Head and Neck Cancer Patients

Phase 4 Withdrawn

Depressive Disorder, Head and Neck Neoplasms

NCT04272294 2024-11-26

Functional and Molecular Characterization of Treatment Response in Tumors in the Oral Cavity Using Optical Spectroscopy

Head and Neck Neoplasms

NCT00756795 2024-09-23

I-PAP

Head and Neck Neoplasms

NCT03747562 2024-09-19

stREnGTH

Phase 3 Withdrawn

Head and Neck Neoplasms, Neuralgia

NCT05849142 2024-09-19

OPC-V

Oropharyngeal Neoplasms

NCT03423264 2024-07-31

PROGRESS Trial - Prophylactic Gabapentin for Relief of Symptoms and Improved Swallowing

Oropharyngeal Neoplasms

NCT06084845 2024-07-25

Testing the Addition of an Investigational Drug, Xevinapant, to Usual Radiation Therapy Plus Cisplatin/Carboplatin for Patients With Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms

NCT06357858 2024-07-03

ASTX727 and Nivolumab in Squamous Cell Carcinoma of the Head and Neck

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Squamous Cell

NCT05471401 2024-06-13

GI Organ Tracking Via Balloon Applicators

GastrointestinalGenitourinaryHead & NeckThoracic

Colonic Neoplasms, Esophageal Neoplasms, Kidney Neoplasms, Laryngeal Neoplasms, Liver Neoplasms, Lung Neoplasms, Pancreatic Neoplasms, Rectal Neoplasms, Stomach Neoplasms

NCT05707702 2024-05-01

Lactobacillus Lozenges as Preventative Care in Low-grade Dysplasia

Phase 3 Withdrawn

Squamous Cell Carcinoma of Head and Neck

NCT05412875 2024-04-12

Pilot Trial of E Cigarettes in Pts Diagnosed With Cancer of the Head, Neck, and Lung

Head & NeckThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms

NCT04731740 2024-03-25

Pembrolizumab and Lenvatinib/Chemotherapy for Poorly Differentiated/Anaplastic Thyroid Cancer

Thyroid Neoplasms

NCT04739566 2024-03-25

ANAPLAST-NEO

EndocrineHead & Neck

Thyroid Carcinoma, Anaplastic

NCT05472506 2024-03-15

Oral AHR Antagonist in Combination With Nivolumab in Patients With PD-1 Resistant Metastatic or Recurrent Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms

NCT04140513 2024-03-08

Digital PET Scan for the Prediction of Outcomes in Patients With Locally Advanced Oropharyngeal Cancer

Carcinoma, Oropharyngeal Neoplasms

NCT05263648 2024-02-14

OU-SCC VR

BreastHead & Neck

Breast Neoplasms, Head and Neck Neoplasms

NCT05331131 2024-01-24

Efficacy of Ketamine Mouthwash in the Management of Oral and Pharyngeal Toxicity Associated With Head and Neck Chemoradiotherapy: A Phase 2, Simon 2-stage Trial

Head and Neck Neoplasms, Stomatitis

NCT05724849 2024-01-18

Venlafaxine for the Prevention of Depression in Patients With Head and Neck Cancer

Depression, Head and Neck Neoplasms

NCT05490381 2023-12-12

Preoperative Embolization of Hypervascular Head and Neck Tumors to Improve Surgical Outcomes

Head & NeckOther neoplasm

Malignant Neoplasm in the Head and Neck

NCT04892875 2023-11-30

PANTHEoN

Squamous Cell Carcinoma of Head and Neck, Head and Neck Neoplasms, Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Mouth Neoplasms, Oropharyngeal Neoplasms, Pharyngeal Neoplasms

NCT06090318 2023-10-19

Milademetan in Combination With Atezolizumab in Patients With Advanced Solid Tumors With CDKN2A Loss

DermatologicGastrointestinalGenitourinaryHead & NeckOther solid neoplasmThoracic

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Renal Cell, Melanoma, Mesothelioma, Stomach Neoplasms

NCT03875053 2023-10-04

Home Sleep Apnea Machine in Evaluating Obstructive Sleep Apnea in Patients With Stage III-IV Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck

NCT05359692 2023-09-15

INCAGN01876 in Combination With Immunotherapy in Participants With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Carcinoma, Squamous Cell

NCT04834349 2023-09-13

Re-irradiation With NBTXR3 in Combination With Pembrolizumab for the Treatment of Inoperable Locoregional Recurrent Head and Neck Squamous Cell Cancer

Squamous Cell Carcinoma of Head and Neck

NCT05535023 2023-09-13

Phase 2 Study of Neoadjuvant SAR444245 Plus Cemiplimab in HPV Related Oropharynx Squamous Cell Carcinoma

Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms

NCT04922112 2023-08-02

OSA-HN