Announcements Trials
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Phase

Phase 3 2Phase 2 2

Status

Active not recruiting 2Recruiting 1Completed 1

Sponsor Class

NIH 2OTHER 1NETWORK 1

Study Type

Interventional 4

Sponsor

Cancer Type

Lymphoid 4Other hematologic neoplasm 3

Conditions

Precursor Cell Lymphoblastic Leukemia-Lymphoma 109Leukemia 41Burkitt Lymphoma 26Lymphoma 18Leukemia, Biphenotypic, Acute 10Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 8Precursor B-Cell Lymphoblastic Leukemia-Lymphoma 5Neoplasm, Residual 5Down Syndrome 4Leukemia, T-Cell 3Dendritic Cell Sarcoma, Interdigitating 3Neoplasms 2Lymphoma, Non-Hodgkin 2Lymphoma, Large B-Cell, Diffuse 2Thrombocytopenia 1Philadelphia Chromosome 1Neutropenia 1Lymphoma, T-Cell 1Lymphoma, Mantle-Cell 1Lymphoma, Large-Cell, Immunoblastic 1Lymphoma, Large-Cell, Anaplastic 1Lymphoma, B-Cell, Marginal Zone 1Leukemia, Myeloid, Acute 1Leukemia, Myelogenous, Chronic, BCR-ABL Positive 1Leukemia, Lymphocytic, Chronic, B-Cell 1Leukemia, B-Cell 1Drug-Related Side Effects and Adverse Reactions 1Cardiotoxicity 1Blast Crisis 1

Interventions

Vincristine 4Methotrexate 4Mercaptopurine 4Cytarabine 4pegaspargase 3merphos 3dexamethasone acetate 3dexamethasone 21-phosphate 3azathiopurine 3auricularum 3Dexamethasone 3Cyclophosphamide 3Calcium Dobesilate 3prednylidene 2blinatumomab 2Thioguanine 2Prednisolone 2N,N-dicyclohexyl-isoborneol-10-sulfonamide 2Leucovorin 2Hydrocortisone 2Doxorubicin 2Asparaginase 2hydrocortisone hemisuccinate 1deltacortene 1calaspargase pegol 1asparaginase erwinia chrysanthemi recombinant 1Spinal Puncture 1Specimen Handling 1Radiotherapy, Conformal 1Radiotherapy 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Down Syndrome × Mercaptopurine × Lymphoid × Clear all
NCT01190930 2026-05-28

Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma

Children's Oncology Group

Phase 3 Completed
9,350 enrolled 51 charts
LymphoidOther hematologic neoplasm

Down Syndrome, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03914625 2026-05-27

A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

National Cancer Institute (NCI)

Phase 3 Active not recruiting
6,720 enrolled
LymphoidOther hematologic neoplasm

Burkitt Lymphoma, Down Syndrome, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

NCT03286634 2026-05-11

ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016

National Hospital Organization Nagoya Medical Center

Phase 2 Active not recruiting
60 enrolled
LymphoidOther hematologic neoplasm

Down Syndrome, Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT04546399 2025-09-10

A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

National Cancer Institute (NCI)

Phase 2 Recruiting
461 enrolled
Lymphoid

Burkitt Lymphoma, Down Syndrome

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