Announcements Trials
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Phase

Phase 3 2Phase 2 2

Status

Active not recruiting 2Recruiting 1Completed 1

Sponsor Class

NIH 2OTHER 1NETWORK 1

Study Type

Interventional 4

Sponsor

Cancer Type

Lymphoid 4Other hematologic neoplasm 3

Conditions

Precursor Cell Lymphoblastic Leukemia-Lymphoma 250Lymphoma 137Leukemia 124Burkitt Lymphoma 90Leukemia, Myeloid, Acute 69Lymphoma, Non-Hodgkin 65Lymphoma, Large B-Cell, Diffuse 59Myelodysplastic Syndromes 54Leukemia, Lymphocytic, Chronic, B-Cell 49Lymphoma, Mantle-Cell 47Hodgkin Disease 47Lymphoma, Follicular 45Leukemia, Myeloid, Accelerated Phase 39Multiple Myeloma 34Lymphoma, Large-Cell, Immunoblastic 33Leukemia, Myeloid, Chronic-Phase 33Recurrence 32Blast Crisis 32Lymphoma, B-Cell, Marginal Zone 31Congenital Abnormalities 31Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 30Myeloproliferative Disorders 30Leukemia, Biphenotypic, Acute 30Graft vs Host Disease 30Leukemia, Myelomonocytic, Chronic 28Dendritic Cell Sarcoma, Interdigitating 25Neoplasms, Plasma Cell 22Primary Myelofibrosis 21Lymphoma, T-Cell, Cutaneous 20Lymphoma, Large-Cell, Anaplastic 20

Interventions

Vincristine 4Methotrexate 4Mercaptopurine 4Cytarabine 4pegaspargase 3merphos 3dexamethasone acetate 3dexamethasone 21-phosphate 3azathiopurine 3auricularum 3Dexamethasone 3Cyclophosphamide 3Calcium Dobesilate 3prednylidene 2blinatumomab 2Thioguanine 2Prednisolone 2N,N-dicyclohexyl-isoborneol-10-sulfonamide 2Leucovorin 2Hydrocortisone 2Doxorubicin 2Asparaginase 2hydrocortisone hemisuccinate 1deltacortene 1calaspargase pegol 1asparaginase erwinia chrysanthemi recombinant 1Spinal Puncture 1Specimen Handling 1Radiotherapy, Conformal 1Radiotherapy 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

4 trials
RecentStart dateEnrollment
Down Syndrome × Methotrexate × Lymphoid × Clear all
NCT01190930 2026-05-28

Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma

Children's Oncology Group

Phase 3 Completed
9,350 enrolled 51 charts
LymphoidOther hematologic neoplasm

Down Syndrome, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT03914625 2026-05-27

A Study to Investigate Blinatumomab in Combination With Chemotherapy in Patients With Newly Diagnosed B-Lymphoblastic Leukemia

National Cancer Institute (NCI)

Phase 3 Active not recruiting
6,720 enrolled
LymphoidOther hematologic neoplasm

Burkitt Lymphoma, Down Syndrome, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

NCT03286634 2026-05-11

ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016

National Hospital Organization Nagoya Medical Center

Phase 2 Active not recruiting
60 enrolled
LymphoidOther hematologic neoplasm

Down Syndrome, Neoplasms, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT04546399 2025-09-10

A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

National Cancer Institute (NCI)

Phase 2 Recruiting
461 enrolled
Lymphoid

Burkitt Lymphoma, Down Syndrome

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