Clinical Trials

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02242942 2025-11-06

Comparison of the Treatments of Obinutuzumab + Venetoclax Versus Obinutuzumab + Chlorambucil in Patients With Chronic Lymphocytic Leukemia

445 enrolled 22 charts 2 FDA

Phase 3 Active not recruiting

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02475681 2025-08-27

ElevateTN

535 enrolled 19 charts 2 FDA

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02612311 2024-12-13

UNITY-CLL

Phase 3 Terminated

603 enrolled 17 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT04578613 2023-06-05

ICP-022 Versus Chlorambucil Combined With Rituximab in the Treatment of Untreated CLL/SLL

218 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02264574 2020-09-21

A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

229 enrolled 29 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01905943 2019-10-28

A Safety and Efficacy Study of Obinutuzumab Alone or in Combination With Chemotherapy in Participants With Chronic Lymphocytic Leukemia

979 enrolled 16 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT00910910 2019-07-09

ORIGIN

450 enrolled 25 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT00748189 2019-06-25

COMPLEMENT 1

Phase 3 Terminated

447 enrolled 32 charts

Neoplasms, Leukemia, B-Cell, Leukemia, Lymphocytic, Chronic, B-Cell

NCT00210353 2019-06-06

Randomized Trial of Chlorambucil Versus Chlorambucil Plus Rituximab Versus Rituximab in MALT Lymphoma

454 enrolled 16 charts

Lymphoma, B-Cell, Marginal Zone

NCT00262795 2019-05-23

Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia

206 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01980875 2018-11-19

Efficacy and Safety of Idelalisib in Combination With Obinutuzumab Compared to Chlorambucil in Combination With Obinutuzumab for Previously Untreated Chronic Lymphocytic Leukemia

Phase 3 Terminated

57 enrolled 12 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01010061 2018-09-14

CLL11: A Study of Obinutuzumab (RO5072759 [GA101]) With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1a)

787 enrolled 20 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01998880 2018-09-14

CLL11: A Study of Rituximab With Chlorambucil or Chlorambucil Alone in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1b)

787 enrolled 19 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02053610 2018-09-14

CLL11: A Study of Obinutuzumab (RO5072759 [GA101]) With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 2)

787 enrolled 19 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01722487 2017-11-30

Open-label Phase 3 BTK Inhibitor Ibrutinib vs Chlorambucil Patients 65 Years or Older With Treatment-naive CLL or SLL

269 enrolled 14 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT00566332 2015-08-19

Trial Comparing Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia

414 enrolled

Waldenstrom Macroglobulinemia, Lymphoma, B-Cell, Marginal Zone

NCT00004218 2013-12-18

Chemotherapy in Treating Patients With Newly Diagnosed Chronic Lymphocytic Leukemia

Leukemia, Leukemia, Lymphocytic, Chronic, B-Cell

NCT00003421 2013-12-04

Combination Chemotherapy in Treating Patients With Advanced Hodgkin's Disease

800 enrolled

Hodgkin Disease, Lymphoma

NCT00006250 2013-09-20

Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Non-Hodgkin's Lymphoma

500 enrolled

Lymphoma, Lymphoma, Follicular

NCT00003639 2013-09-17

Combination Chemotherapy With or Without Interferon Alfa in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma

200 enrolled

Lymphoma, Lymphoma, Follicular, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, B-Cell, Marginal Zone

NCT00028691 2013-09-17

Chlorambucil Compared With Radiation Therapy in Treating Patients With Previously Untreated Stage III or Stage IV Follicular Lymphoma

Lymphoma, Lymphoma, Follicular

NCT00608374 2013-08-26

Chlorambucil or Fludarabine as First-Line Therapy in Treating Patients With Previously Untreated Waldenström Macroglobulinemia, Splenic Lymphoma, or Lymphoplasmacytic Lymphoma

400 enrolled

Lymphoma, Waldenstrom Macroglobulinemia, Lymphoma, B-Cell, Marginal Zone

NCT01678430 2012-10-15

RIAltO

670 enrolled

Leukemia, B-Cell

NCT01657955 2012-08-06

CLL

96 enrolled

Leukemia, Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell

NCT00017108 2008-07-24

Chlorambucil in Treating Patients With Advanced Chronic Lymphocytic Leukemia