Announcements Trials
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Phase

Phase 1/2 1

Status

Withdrawn 1Recruiting 1Completed 1

Sponsor Class

INDUSTRY 1

Study Type

Interventional 1

Sponsor

Cancer Type

CNS 19Other neoplasm 2Sarcoma 1Myeloid 1Dermatologic 1

Conditions

Myelodysplastic Syndromes 750Leukemia, Myeloid, Acute 635Leukemia 476Leukemia, Myelogenous, Chronic, BCR-ABL Positive 470Precursor Cell Lymphoblastic Leukemia-Lymphoma 409Myeloproliferative Disorders 339Lymphoma, Non-Hodgkin 271Leukemia, Myelomonocytic, Chronic 270Leukemia, Lymphocytic, Chronic, B-Cell 264Multiple Myeloma 259Hodgkin Disease 249Primary Myelofibrosis 230Leukemia, Myeloid, Chronic-Phase 217Lymphoma 203Blast Crisis 195Leukemia, Myeloid, Accelerated Phase 182Lymphoma, Mantle-Cell 168Lymphoma, Follicular 168Burkitt Lymphoma 166Lymphoma, Large B-Cell, Diffuse 162Lymphoma, B-Cell, Marginal Zone 151Congenital Abnormalities 148Polycythemia Vera 144Lymphoma, Large-Cell, Immunoblastic 141Anemia, Refractory, with Excess of Blasts 131Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative 128Myelodysplastic-Myeloproliferative Diseases 126Neoplasms, Plasma Cell 117Thrombocythemia, Essential 114Lymphoma, T-Cell, Cutaneous 99

Interventions

trametinib 1dabrafenib 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

1 trials
RecentStart dateEnrollment
Completed × Neurofibroma, Plexiform × Myeloid × Clear all
NCT02124772 2021-07-14

Study to Investigate Safety, Pharmacokinetic (PK), Pharmacodynamic (PD) and Clinical Activity of Trametinib in Subjects With Cancer or Plexiform Neurofibromas and Trametinib in Combination With Dabrafenib in Subjects With Cancers Harboring V600 Mutations

Novartis

Phase 1/2 Completed
139 enrolled 42 charts 1 FDA
CNSMyeloid

Histiocytosis, Langerhans-Cell, Neoplasms, Neuroblastoma, Neurofibroma, Plexiform

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