Announcements Trials
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Phase

Phase 1 3Phase 3 2

Status

Active not recruiting 3Completed 2

Sponsor Class

INDUSTRY 3OTHER 2

Study Type

Interventional 5

Sponsor

Cancer Type

Myeloid 5Other hematologic neoplasm 4Tumor-Agnostic 1Lymphoid 1Dermatologic 1

Conditions

Primary Myelofibrosis 4Neoplasms 3Myelodysplastic Syndromes 2Leukemia, Myeloid, Acute 2Recurrence 1Myeloproliferative Disorders 1

Interventions

fludarabine 63Cyclophosphamide 63venetoclax 57Azacitidine 52fludarabine phosphate 50Specimen Handling 44Whole-Body Irradiation 40ruxolitinib 37Mycophenolic Acid 37Tacrolimus 35Melphalan 32Busulfan 32Biopsy 32Cytarabine 31Stem Cell Transplantation 27Decitabine 27Granulocyte Colony-Stimulating Factor 21asciminib 19decitabine and cedazuridine drug combination 18Sirolimus 18Peripheral Blood Stem Cell Transplantation 18Injections 18Thiotepa 17Filgrastim 17nilotinib 15X-Rays 14Methotrexate 14Cyclosporine 14Imatinib Mesylate 13Magnetic Resonance Spectroscopy 12

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
navitoclax × Myeloid × 1 year × Clear all
NCT05564650 2026-05-19

Navitoclax in Relapsed or Refractory High-Risk Myelodysplastic Syndrome

Thomas Jefferson University

Phase 1 Completed
6 enrolled
MyeloidOther hematologic neoplasm

Myelodysplastic Syndromes, Recurrence, Leukemia, Myeloid, Acute

NCT04472598 2026-03-23

TRANSFORM-1

AbbVie

Phase 3 Completed
252 enrolled 17 charts
Myeloid

Neoplasms, Primary Myelofibrosis

NCT05455294 2026-01-28

Combination Navitoclax, Venetoclax and Decitabine for Advanced Myeloid Neoplasms

Dana-Farber Cancer Institute

Phase 1 Active not recruiting
16 enrolled
MyeloidOther hematologic neoplasm

Myelodysplastic Syndromes, Myeloproliferative Disorders, Leukemia, Myeloid, Acute, Primary Myelofibrosis

NCT04468984 2026-01-09

TRANSFORM-2

AbbVie

Phase 3 Active not recruiting
330 enrolled
Myeloid

Neoplasms, Primary Myelofibrosis

NCT04454658 2025-07-16

Safety and Tolerability Study of Oral ABBV-744 Tablet Alone or in Combination With Oral Ruxolitinib Tablet or Oral Navitoclax Tablet in Adult Participants With Myelofibrosis

AbbVie

Phase 1 Active not recruiting
21 enrolled
Myeloid

Neoplasms, Primary Myelofibrosis

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