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Phase

Phase EARLY_PHASE1 1Phase 2 1

Status

Terminated 1Completed 1

Sponsor Class

OTHER 2

Study Type

Interventional 2

Sponsor

Cancer Type

Plasma cell 4Other hematologic neoplasm 2Lymphoid 2Other solid neoplasm 1Gastrointestinal 1

Conditions

Precursor Cell Lymphoblastic Leukemia-Lymphoma 1Multiple Myeloma 1Lymphoma, Non-Hodgkin 1Lymphoma 1Leukemia, Large Granular Lymphocytic 1Cytokine Release Syndrome 1

Interventions

venetoclax 304Cyclophosphamide 229Cytarabine 199Azacitidine 187fludarabine 180Specimen Handling 136Biopsy 103fludarabine phosphate 97Methotrexate 81Rituximab 78Daunorubicin 77Dexamethasone 75Vincristine 68Whole-Body Irradiation 64Mycophenolic Acid 59Decitabine 57Tacrolimus 55Etoposide 52ibrutinib 51blinatumomab 51Granulocyte Colony-Stimulating Factor 51Busulfan 50obinutuzumab 49Prednisone 49Melphalan 48acalabrutinib 45Idarubicin 45Stem Cell Transplantation 44Injections 44Magnetic Resonance Spectroscopy 43

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
siltuximab × Other hematologic neoplasm × 1 year × Clear all
NCT04975555 2026-06-03

Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy

University of Alabama at Birmingham

Phase 2 Completed
24 enrolled 8 charts
LymphoidOther hematologic neoplasmPlasma cell

Cytokine Release Syndrome, Lymphoma, Lymphoma, Non-Hodgkin, Multiple Myeloma, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT05316116 2026-02-05

Siltuximab in Large Granular Lymphocytic Leukemia (LGLL)

H. Lee Moffitt Cancer Center and Research Institute

Phase EARLY_PHASE1 Terminated
6 enrolled
Other hematologic neoplasm

Leukemia, Large Granular Lymphocytic

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