Clinical Trials

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02242942 2025-11-06

Comparison of the Treatments of Obinutuzumab + Venetoclax Versus Obinutuzumab + Chlorambucil in Patients With Chronic Lymphocytic Leukemia

445 enrolled 22 charts 1 FDA

Phase 3 Active not recruiting

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02475681 2025-08-27

ElevateTN

535 enrolled 19 charts 1 FDA

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02612311 2024-12-13

UNITY-CLL

Phase 3 Terminated

603 enrolled 17 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT04578613 2023-06-05

ICP-022 Versus Chlorambucil Combined With Rituximab in the Treatment of Untreated CLL/SLL

218 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT00558961 2023-03-27

GL-CLB-001

Phase 1/2 Terminated

13 enrolled

Leukemia, Leukemia, Lymphocytic, Chronic, B-Cell

NCT02336048 2021-04-08

A Study Evaluating the Safety of Tocilizumab in Addition to Standard of Care Premedication Given Before Obinutuzumab + Chlorambucil in Participants With Untreated B-Cell Chronic Lymphocytic Leukemia (B-CLL) and Comorbidities

Phase 1 Terminated

38 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01088048 2021-03-18

Study to Investigate Idelalisib in Combination With Chemotherapeutic Agents, Immunomodulatory Agents and Anti-CD20 Monoclonal Antibody (mAb) in Participants With Relapsed or Refractory Indolent B-cell Non-Hodgkin's Lymphoma, Mantle Cell Lymphoma or Chronic Lymphocytic Leukemia

Phase 1 Completed

241 enrolled 31 charts

Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Mantle-Cell

NCT02264574 2020-09-21

A Multi-Center Study of Ibrutinib in Combination With Obinutuzumab Versus Chlorambucil in Combination With Obinutuzumab in Patients With Treatment naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

229 enrolled 29 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01905943 2019-10-28

A Safety and Efficacy Study of Obinutuzumab Alone or in Combination With Chemotherapy in Participants With Chronic Lymphocytic Leukemia

979 enrolled 16 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02100852 2019-10-02

TGR-1202, a PI3K Delta Inhibitor, in Combination With Obinutuzumab and Chlorambucil in Patients With Chronic Lymphocytic Leukemia (CLL)

Phase 1 Completed

19 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT00910910 2019-07-09

ORIGIN

450 enrolled 25 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT00748189 2019-06-25

COMPLEMENT 1

Phase 3 Terminated

447 enrolled 32 charts

Neoplasms, Leukemia, B-Cell, Leukemia, Lymphocytic, Chronic, B-Cell

NCT00262795 2019-05-23

Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia

206 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01283386 2019-03-14

A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Participants With Chronic Lymphocytic Leukemia and Unfavorable Somatic Status

Phase 4 Terminated

26 enrolled 13 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01403246 2019-02-12

Chlorambucil + Lenalidomide and Lenalidomide Maintenance in Untreated Elderly With Chronic Lymphocytic Leukemia (CLL)

Phase 1/2 Terminated

9 enrolled 5 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01980875 2018-11-19

Efficacy and Safety of Idelalisib in Combination With Obinutuzumab Compared to Chlorambucil in Combination With Obinutuzumab for Previously Untreated Chronic Lymphocytic Leukemia

Phase 3 Terminated

57 enrolled 12 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01010061 2018-09-14

CLL11: A Study of Obinutuzumab (RO5072759 [GA101]) With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1a)

787 enrolled 20 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01998880 2018-09-14

CLL11: A Study of Rituximab With Chlorambucil or Chlorambucil Alone in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 1b)

787 enrolled 19 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT02053610 2018-09-14

CLL11: A Study of Obinutuzumab (RO5072759 [GA101]) With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia (Stage 2)

787 enrolled 19 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01722487 2017-11-30

Open-label Phase 3 BTK Inhibitor Ibrutinib vs Chlorambucil Patients 65 Years or Older With Treatment-naive CLL or SLL

269 enrolled 14 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT00738374 2017-08-15

A Study of MabThera (Rituximab) Plus Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia.

97 enrolled 27 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01868893 2017-04-17

An Expanded Access, Open-Label Study of Obinutuzumab (GA101) Plus Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia

20 enrolled 8 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT00532129 2016-04-06

A Study of MabThera (Rituximab) Plus Chlorambucil in Participants With Chronic Lymphocytic Leukemia.

100 enrolled 17 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01563055 2015-08-10

A Phase I/II, Open-label Study of Ofatumumab Added to Chlorambucil in Previously Untreated Japanese Patients With Chronic Lymphocytic Leukemia

10 enrolled 52 charts

Leukemia, B-Cell

NCT01056510 2015-06-25

A Study of MabThera Added to Bendamustine or Chlorambucil in Patients With Chronic Lymphocytic Leukemia (MaBLe)

Phase 4 Completed

357 enrolled 25 charts

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01808326 2015-06-22

A Phase II, Open Label, Single Arm, Multicenter Study of Chlorambucil in Japanese Previously Untreated Patients With Chronic Lymphocytic Leukemia

Other hematologic neoplasm

5 enrolled 23 charts

Leukemia

NCT00004218 2013-12-18

Chemotherapy in Treating Patients With Newly Diagnosed Chronic Lymphocytic Leukemia

Leukemia, Leukemia, Lymphocytic, Chronic, B-Cell

NCT00003639 2013-09-17

Combination Chemotherapy With or Without Interferon Alfa in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma

200 enrolled

Lymphoma, Lymphoma, Follicular, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, B-Cell, Marginal Zone

NCT01109264 2013-08-23

Bendamustine Hydrochloride Injection for Initial Treatment of Chronic Lymphocytic Leukemia

147 enrolled

Leukemia, Lymphocytic, Chronic, B-Cell

NCT01678430 2012-10-15

RIAltO

670 enrolled

Leukemia, B-Cell

NCT01657955 2012-08-06

CLL

96 enrolled

Leukemia, Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell

NCT00151736 2012-06-11

Safety and Efficacy of SDX-101 (R-Etodolac) in Combination With Chlorambucil, and That of Chlorambucil Alone, in Patients With Chronic Lymphocytic Leukemia (CLL)

Phase 2 Terminated

88 enrolled

Leukemia, Leukemia, Lymphocytic, Chronic, B-Cell

NCT00017108 2008-07-24

Chlorambucil in Treating Patients With Advanced Chronic Lymphocytic Leukemia