Announcements Trials
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Phase

Phase 1/2 1Phase 1 1

Status

Terminated 1Recruiting 1

Sponsor Class

NIH 2

Study Type

Interventional 2

Sponsor

Cancer Type

Thoracic 12Gynecologic 5Gastrointestinal 5Genitourinary 4Dermatologic 4Breast 3Sarcoma 2Other solid neoplasm 2Head & Neck 2Plasma cell 1CNS 1

Conditions

Mesothelioma 6Solid Tumor 4Pancreatic Neoplasms 4Ovarian Neoplasms 4Mesothelioma, Malignant 4Advanced Solid Tumors 4Solid Tumors 3Stomach Neoplasms 2Solid Tumor, Adult 2Lung Neoplasms 2Colorectal Neoplasms 2Cholangiocarcinoma 2Carcinoma, Non-Small-Cell Lung 2Advanced Solid Tumor 2Uterine Cervical Neoplasms 1Turcot syndrome 1Triple Negative Breast Neoplasms 1Thymus Neoplasms 1Thymoma 1Select Advanced Solid Tumors 1Sarcoma 1Relapsed Pediatric Solid Tumor 1Neuroendocrine Tumors 1Neoplasms, Squamous Cell 1Neoplasms 1Neoplasm Metastasis 1Microsatellite Instability 1Mesothelin-positive Advanced Refractory Solid Tumors 1Mesothelin-positive Advanced Malignant Solid Tumors 1KRAS G12V 1

Interventions

Cyclophosphamide 6pembrolizumab 5Cisplatin 4sargramostim 3Pemetrexed 3Decitabine 3Celecoxib 3fludarabine 2belinostat 2SS1(dsFv)PE38 2Quality of Life 2Plicamycin 2Nivolumab 2Ipilimumab 2FANG vaccine 2Drug Therapy 2perflutren 1olaparib 1niraparib 1iodixanol 1incomplete Freund's adjuvant 1fludarabine phosphate 1dostarlimab 1anetumab ravtansine 1aldesleukin 1alanosine 1Vorinostat 1Valacyclovir 1UV1 vaccine 1Tumor Burden 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Lung Neoplasms × fludarabine × Other solid neoplasm × Clear all
NCT06885697 2026-02-17

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

National Institutes of Health Clinical Center (CC)

Phase 1 Recruiting
100 enrolled
GastrointestinalGynecologicOther solid neoplasmThoracic

Colonic Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Thymoma, Thymus Neoplasms

NCT01583686 2019-10-14

CAR T Cell Receptor Immunotherapy Targeting Mesothelin for Patients With Metastatic Cancer

National Institutes of Health Clinical Center (CC)

Phase 1/2 Terminated
15 enrolled 14 charts
GastrointestinalGynecologicOther solid neoplasmThoracic

Uterine Cervical Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms

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