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Phase

Phase 1 1

Status

Active not recruiting 1

Sponsor Class

OTHER 1

Study Type

Interventional 1

Sponsor

Cancer Type

Sarcoma 2Head & Neck 2Gynecologic 2Genitourinary 2CNS 2Thoracic 1Other solid neoplasm 1Lymphoid 1Gastrointestinal 1Endocrine 1Dermatologic 1

Conditions

Mesothelioma 21Mesothelioma, Malignant 18Advanced Solid Tumor 17Carcinoma, Non-Small-Cell Lung 15Solid Tumor 14Advanced Solid Tumors 13Melanoma 12Esophageal Neoplasms 10Carcinoma, Renal Cell 10Stomach Neoplasms 9Squamous Cell Carcinoma of Head and Neck 9Uterine Cervical Neoplasms 8Solid Tumors 8Ovarian Neoplasms 8Solid Tumor, Adult 7Neoplasm Metastasis 7Colorectal Neoplasms 7Triple Negative Breast Neoplasms 6Small Cell Lung Carcinoma 6Breast Neoplasms 6Pancreatic Neoplasms 5Lung Neoplasms 5Endometrial Neoplasms 5Cholangiocarcinoma 5Neoplasms 4Locally Advanced or Metastatic Solid Tumors 4Head and Neck Neoplasms 4Advanced or Metastatic Solid Tumors 4Urinary Bladder Neoplasms 3Solid Tumor Malignancies 3

Interventions

Granulocyte Colony-Stimulating Factor 2pembrolizumab 1pegylated granulocyte colony-stimulating factor 1etoposide phosphate 1Ursodeoxycholic Acid 1Topotecan 1Thiotepa 1Sirolimus 1Simvastatin 1Radiation 1Plicamycin 1Paclitaxel 1Mesna 1Melphalan 1Leukapheresis 1Ifosfamide 1Etoposide 1Cyclophosphamide 1Carboplatin 1Busulfan 1

Date Range

30 days90 days1 yearAll

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Clinical Trials

1 trials
RecentStart dateEnrollment
Neoplasms, Germ Cell and Embryonal × pembrolizumab × Other solid neoplasm × Clear all
NCT04483778 2026-04-28

B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

Seattle Children's Hospital

Phase 1 Active not recruiting
68 enrolled
CNSDermatologicGastrointestinalGenitourinaryOther solid neoplasmSarcoma

Carcinoma, Melanoma, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Hepatoblastoma, Sarcoma, Clear Cell, Neurofibrosarcoma, Rhabdoid Tumor, Desmoplastic Small Round Cell Tumor

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