Announcements Trials
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Phase

Phase 1 5

Status

Completed 5

Sponsor Class

INDUSTRY 5

Study Type

Interventional 5

Sponsor

Cancer Type

Other solid neoplasm 5

Conditions

Solid Tumours 5Solid Tumors 1Locally Advanced or Metastatic Solid Tumors 1

Interventions

AZD 6244 5GSK 1363089 3molibresib 2pazopanib 1ispinesib 1enzalutamide 1brigimadlin 1abiraterone 1Topotecan 1SLC-0111 1Rifampin 1Prednisone 1Omeprazole 1Moxifloxacin 1Midazolam 1Itraconazole 1Granisetron 1Fluconazole 1Famotidine 1Doxorubicin 1Cytochrome P-450 CYP3A 1Cytochrome P-450 CYP2C19 1Cytochrome P-450 CYP1A2 1Carboplatin 1Carbon-14 1Caffeine 1CH5183284 1BGC945 12-((3-((4-((5-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate 11-(1-(imidazo(1,2-a)pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-(1,2,3)triazolo(4,5-b)pyrazine 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Solid Tumours × AZD 6244 × Other solid neoplasm × Clear all
NCT02056392 2015-11-09

To Assess the Effects of Single Oral Dose of Selumetinib [AZD6244; ARRY-142886] [Hyd-Sulfate]), on QTc Interval in Healthy Male Volunteers

AstraZeneca

Phase 1 Completed
54 enrolled 31 charts
Other solid neoplasm

Solid Tumours

NCT01931761 2015-06-30

Study Evaluating Absorption, Distribution, Metabolism and Excretion (ADME) of Single Dose [14C] Selumetinib in Volunteers

AstraZeneca

Phase 1 Completed
6 enrolled
Other solid neoplasm

Solid Tumours

NCT02093728 2015-06-30

To Assess the Effect of Itraconazole and Fluconazole on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers

AstraZeneca

Phase 1 Completed
26 enrolled
Other solid neoplasm

Solid Tumours

NCT01974349 2014-08-13

To Assess the Effect of Food on the Pharmacokinetics of Selumetinib (AZD6244; ARRY-142886) (Hyd-Sulfate) in Healthy Male Volunteers

AstraZeneca

Phase 1 Completed
39 enrolled
Other solid neoplasm

Solid Tumours

NCT02046850 2014-04-29

To Assess the Effect of Rifampicin on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers

AstraZeneca

Phase 1 Completed
24 enrolled
Other solid neoplasm

Solid Tumours

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