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Phase

Phase 1 1

Status

Recruiting 1

Sponsor Class

NIH 1

Study Type

Interventional 1

Sponsor

Cancer Type

Thoracic 1Other solid neoplasm 1Gynecologic 1Gastrointestinal 1

Conditions

Mesothelioma, Malignant 13Retinoblastoma 9Mesothelioma 9Solid Tumor 7Sarcoma 6Pancreatic Neoplasms 6Lung Neoplasms 6Unspecified Childhood Solid Tumor, Protocol Specific 5Unspecified Adult Solid Tumor, Protocol Specific 5Solid Tumors 5Carcinoma, Non-Small-Cell Lung 5Ovarian Neoplasms 4Wilms Tumor 3Solid Tumor, Adult 3Neuroblastoma 3Colorectal Neoplasms 3Advanced Solid Tumors 3Advanced Solid Tumor 3Thymoma 2Stomach Neoplasms 2Sarcoma, Ewing 2Rhabdomyosarcoma 2Osteosarcoma 2Neoplasms 2Neoplasm Metastasis 2Kidney Neoplasms 2Colonic Neoplasms 2Cholangiocarcinoma 2Carcinoma, Renal Cell 2Breast Neoplasms 2

Interventions

pembrolizumab 2Quality of Life 2fludarabine 1bosutinib 1Tumor Burden 1Plicamycin 1Pemetrexed 1Patient Reported Outcome Measures 1Molecular Diagnostic Techniques 1Immunotherapy 1Histocompatibility Testing 1Drug Therapy 1Cyclophosphamide 1Blood Specimen Collection 1Biological Therapy 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

1 trials
RecentStart dateEnrollment
Thymus Neoplasms × Cyclophosphamide × Other solid neoplasm × Clear all
NCT06885697 2026-06-04

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

National Institutes of Health Clinical Center (CC)

Phase 1 Recruiting
100 enrolled
GastrointestinalGynecologicOther solid neoplasmThoracic

Colonic Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Thymoma, Thymus Neoplasms

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