Clinical Trials

63 enrolled

Childhood Solid Tumor

NCT04469530 2026-02-27

AflacST1903

Phase 2 Recruiting

55 enrolled

Solid Tumor

NCT06885697 2026-02-17

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

GastrointestinalGynecologicOther solid neoplasmThoracic

100 enrolled

Colonic Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Thymoma, Thymus Neoplasms

NCT06556108 2026-01-20

ALPP CAR-T Cells for ALPP-Positive Advanced Solid Tumors

Phase 1/2 Completed

5 enrolled

Phase EARLY_PHASE1 Not yet recruiting

Advanced Solid Tumors

NCT07342738 2026-01-15

TCR-T Cell Therapy for KRAS Mutation in Advanced Solid Tumors

25 enrolled

Phase 2 Active not recruiting

KRAS G12V

NCT02870907 2026-01-07

RB SFCE 09

195 enrolled

Retinoblastoma

NCT05380713 2025-12-29

......SMARTEST Trial......

Phase 2 Completed

Mesothelioma, Malignant

NCT06241456 2025-12-09

FT825/ONO-8250, an Off-the-Shelf, HER2 CAR-T, With or Without Monoclonal Antibodies in Advanced Solid Tumors

351 enrolled

Advanced Solid Tumor

NCT02414269 2025-10-08

Malignant Pleural Disease Treated With Autologous T Cells Genetically Engineered to Target the Cancer-Cell Surface Antigen Mesothelin

BreastOther solid neoplasmThoracic

113 enrolled

Breast Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasm Metastasis

NCT00186888 2025-09-04

Study of Treatment for Patients With Cancer of the Eye -Retinoblastoma

Phase 3 Completed

107 enrolled 34 charts

Eye Neoplasms, Retinoblastoma, Retinal Neoplasms

NCT03907852 2025-08-27

Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer

GastrointestinalGynecologicOther solid neoplasmThoracic

57 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Mesothelioma, Ovarian Neoplasms, Cholangiocarcinoma

NCT05451849 2025-08-27

A Phase 1/2 Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer

BreastGastrointestinalGynecologicOther solid neoplasmThoracic

6 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Mesothelioma, Ovarian Neoplasms, Pancreatic Neoplasms, Colorectal Neoplasms, Cholangiocarcinoma, Triple Negative Breast Neoplasms

NCT05279300 2025-08-11

A Study of CS5001 in Patients With Advanced Solid Tumors and Lymphomas

LymphoidOther solid neoplasm

480 enrolled

Advanced Solid Tumor

NCT02498912 2025-07-31

Cyclophosphamide Followed by Intravenous and Intraperitoneal Infusion of Autologous T Cells Genetically Engineered to Secrete IL-12 and to Target the MUC16ecto Antigen in Patients With Recurrent MUC16ecto+ Solid Tumors

Phase 1 Active not recruiting

18 enrolled

Phase 1 Active not recruiting

Solid Tumors

NCT04577326 2025-07-25

Mesothelin-targeted CAR T-cell Therapy in Patients With Mesothelioma

14 enrolled

Mesothelioma, Malignant

NCT05275777 2025-07-25

A Phase Ib Safety lead-in, Followed by Phase II Trial of ADG106 in Combination With Neoadjuvant Chemotherapy in HER2 Negative Breast Cancer

BreastOther solid neoplasm

66 enrolled

HER2-negative Breast Cancer

NCT05881525 2025-07-16

NY-ESO-1 TCR-T Cells for NY-ESO-1 Positive Subjects With Advanced Solid Tumors

18 enrolled

DermatologicEndocrineGastrointestinalNETOther solid neoplasmSarcomaThoracic

Advanced Solid Tumors

NCT03935893 2025-07-10

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers

Phase 2 Recruiting

240 enrolled

Turcot syndrome, Mesothelioma, Pancreatic Neoplasms, Sarcoma, Stomach Neoplasms, Colorectal Neoplasms, Carcinoma, Merkel Cell, Neoplasms, Squamous Cell, Neuroendocrine Tumors, Microsatellite Instability

NCT07010523 2025-06-08

Anti-Mesothelin CAR-T Cell Injection in Patients With Mesothelin-positive Advanced Malignant Solid Tumors

Phase NA Recruiting

24 enrolled

Phase 1 Active not recruiting

Mesothelin-positive Advanced Malignant Solid Tumors

NCT04643574 2025-02-14

NeoTIL in Advanced Solid Tumors

42 enrolled

Solid Tumor, Adult

NCT05693844 2024-05-10

Pan-T Booster Co-expressing MSLN CAR T Cell Therapy in Advanced/Metastatic Solid Tumors

Phase 1/2 Recruiting

15 enrolled

Advanced or Metastatic Solid Tumors

NCT06394622 2024-05-01

A Clinical Research About CD70-targeted CAR-NKT Cells Therapy Advanced Malignant Solid Tumors

12 enrolled

Phase 2 Active not recruiting

Solid Tumor

NCT01783535 2024-04-16

Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma

174 enrolled

Retinoblastoma

NCT06101082 2024-03-06

A Clinical Study Evaluating the Safety and Efficacy of Anti-HER2-CAR-T Cells Injection in Patients With Solid Tumors

9 enrolled

Phase 1 Not yet recruiting

Solid Tumor

NCT06277804 2024-02-26

A Phase I Study of LTC004 Combin With FC in Patients With Advanced/Metastatic Malignancies Tumor

48 enrolled

Adult Solid Tumor

NCT03728179 2024-02-20

RACIN

40 enrolled

Solid Tumor, Adult

NCT01661400 2024-01-31

ASCR

CNSGenitourinaryOther solid neoplasmSarcoma

14 enrolled

Glioma, Medulloblastoma, Wilms Tumor, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma, Neuroectodermal Tumors, Primitive

NCT05681650 2023-12-12

HER2 Targeted HypoSti.CAR-T Cells in HER2 Positive Advanced Solid Tumors

Phase 1/2 Recruiting

HER2 Positive Advanced Solid Tumors

NCT03139370 2023-08-25

Safety and Efficacy of MAGE-A3/A6 T Cell Receptor Engineered T Cells (KITE-718) in HLA-DPB1*04:01 Positive Adults With Advanced Cancers

16 enrolled

Solid Tumor

NCT05699811 2023-04-28

IFNα Expressing Mesenchymal Stromal Cells for Locally Advanced/Metastatic Solid Tumors

Phase 1/2 Recruiting

40 enrolled

Locally Advanced or Metastatic Solid Tumors

NCT05531708 2023-03-01

Exploratory Study of Novel MSLN CAR-T Cell Therapy in Patients With MSLN-positive Advanced Refractory Solid Tumors

Phase 1 Withdrawn

Mesothelin-positive Advanced Refractory Solid Tumors

NCT02414945 2023-01-10

TILs & Low-Dose IL-2 Therapy Following Cyclophosphamide and Fludarabine in Pleural Mesothelioma Patients

Phase 1/2 Completed

9 enrolled

Phase EARLY_PHASE1 Unknown

Mesothelioma, Malignant

NCT05649618 2022-12-14

TIL Cells for the Treatment of the Advanced Solid Tumors Patients

42 enrolled

Phase EARLY_PHASE1 Unknown

Solid Tumor

NCT05648994 2022-12-13

TCR-T Cells for the Treatment NY-ESO-1-positive Advanced Solid Tumors

Phase EARLY_PHASE1 Unknown

Solid Tumors

NCT05515185 2022-08-25

B7-H3 Targeting CAR-T Cells Therapy for B7-H3 Positive Solid Tumors

Advanced Solid Tumor

NCT02408016 2021-09-13

Genetically Modified T Cells in Treating Patients With Stage III-IV Non-small Cell Lung Cancer or Mesothelioma

Phase 1/2 Terminated

11 enrolled 9 charts

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung

NCT03608618 2021-09-05

Intraperitoneal MCY-M11 (Mesothelin-targeting CAR) for Treatment of Advanced Ovarian Cancer and Peritoneal Mesothelioma

GynecologicOther solid neoplasmThoracic

14 enrolled

Peritoneal Mesothelioma

NCT03992326 2021-03-18

Adoptive Transfer Of Autologous Tumor-Infiltrating Lymphocytes in Solid Tumors

6 enrolled

Solid Tumor, Adult

NCT01675765 2020-09-30

Safety and Efficacy of Listeria in Combination With Chemotherapy as Front-line Treatment for Malignant Pleural Mesothelioma

60 enrolled 15 charts

Mesothelioma, Malignant, Neoplasms

NCT00390156 2020-07-28

Imatinib, Bevacizumab, and Cyclophosphamide in Patients With Refractory Metastatic Solid Tumors

35 enrolled

Unspecified Adult Solid Tumor

NCT03733587 2020-05-14

GX-I7 With Cyclophosphamide in Patients With Metastatic or Recurrent Solid Tumors

24 enrolled

Solid Tumor

NCT02390843 2020-04-03

AflacST1402

CNSGastrointestinalGenitourinaryOther solid neoplasmSarcoma

13 enrolled

Carcinoma, Renal Cell, Neoplasms, Germ Cell and Embryonal, Wilms Tumor, Neuroblastoma, Retinoblastoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Hepatoblastoma, Sarcoma, Clear Cell, Rhabdoid Tumor

NCT01143545 2020-03-03

Pilot Study of Allogeneic Tumor Cell Vaccine With Metronomic Oral Cyclophosphamide and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers, Thymic Neoplasms, and Malignant Pleural Mesotheliomas