Clinical Trials

35 enrolled

CNSEndocrineGastrointestinalGenitourinaryGynecologicOther solid neoplasmSarcomaThoracic

HRD Cancer

NCT06503146 2026-05-19

18F-Fibroblast Activation Protein Inhibitor ([18F]FAPI-74) PET Imaging for Cancer Detection

Phase 2 Recruiting

320 enrolled

Urinary Bladder Neoplasms, Carcinoma, Hepatocellular, Mesothelioma, Ovarian Neoplasms, Paraganglioma, Pheochromocytoma, Sarcoma, Stomach Neoplasms, Cholangiocarcinoma, Small Cell Lung Carcinoma

NCT06009926 2026-05-13

Evaluation of Broccoli Seed and Sprout Extract for Detoxification of Carcinogens in Firefighters

Other neoplasmOther solid neoplasm

72 enrolled

Hematopoietic and Lymphatic System Neoplasm

NCT06126276 2026-05-13

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Phase 2 Recruiting

70 enrolled

Malignant Female Reproductive System Neoplasm

NCT05960773 2026-05-04

Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma

Phase 2 Suspended

9 enrolled

Mesothelioma, Malignant, Mesothelioma

NCT03228537 2026-05-01

Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma

28 enrolled 17 charts

Mesothelioma, Malignant

NCT01064648 2026-04-29

Pemetrexed Disodium and Cisplatin With or Without Cediranib Maleate in Treating Patients With Malignant Pleural Mesothelioma

117 enrolled 23 charts

Mesothelioma, Malignant, Solitary Fibrous Tumor, Pleural

NCT02535312 2026-04-17

Methoxyamine, Cisplatin, and Pemetrexed Disodium in Treating Patients With Advanced Solid Tumors or Mesothelioma That Cannot Be Removed by Surgery or Mesothelioma That Is Refractory to Pemetrexed Disodium and Cisplatin or Carboplatin

30 enrolled 15 charts

Mesothelioma, Malignant

NCT06360588 2026-04-17

Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Loss (MATCH - Subprotocol Z1G)

22 enrolled 9 charts

Malignant Solid Neoplasm

NCT06351371 2026-04-14

Testing JNJ-42756493 (Erdafitinib) as Potentially Targeting Treatment in Cancers With FGFR Mutations or Fusions (MATCH - Subprotocol K2)

35 enrolled 10 charts

Malignant Solid Neoplasm

NCT01434316 2026-04-13

Veliparib and Dinaciclib in Treating Patients With Advanced Solid Tumors

121 enrolled

Advanced Malignant Solid Neoplasm

NCT02453620 2026-04-13

Entinostat, Nivolumab, and Ipilimumab in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Locally Advanced or Metastatic HER2-Negative Breast Cancer

BreastOther solid neoplasm

57 enrolled

Anatomic Stage III Breast Cancer AJCC v8

NCT04491942 2026-04-13

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to the Usual Chemotherapy Treatment (Cisplatin, or Cisplatin and Gemcitabine) for Advanced Solid Tumors With Emphasis on Urothelial Cancer

BreastGenitourinaryGynecologicOther solid neoplasmThoracic

74 enrolled

Mesothelioma, Malignant, Uterine Cervical Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Penile Neoplasms, Triple Negative Breast Neoplasms

NCT06136897 2026-04-13

Testing Trastuzumab and Pertuzumab in Patients With Higher Than Normal Copies of the HER2 Gene Found in Their Tumors (MATCH - Subprotocol J)

35 enrolled 10 charts

Malignant Solid Neoplasm

NCT03126630 2026-04-01

Pembrolizumab With or Without Anetumab Ravtansine in Treating Patients With Mesothelin-Positive Pleural Mesothelioma

49 enrolled 20 charts

Mesothelioma, Malignant

NCT06654050 2026-03-17

Alrizomadlin (APG-115) in Subjects With BAP1 Cancer Syndrome and Early-Stage Mesothelioma

Phase 2 Withdrawn

GastrointestinalGynecologicOther solid neoplasmThoracic

Mesothelioma, Malignant, Mesothelioma

NCT06885697 2026-02-17

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

Phase 1 Recruiting

100 enrolled

Colonic Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Stomach Neoplasms, Thymoma, Thymus Neoplasms

NCT03388632 2025-12-18

Recombinant Interleukin-15 in Combination With Checkpoint Inhibitors Nivolumab and Ipilimumab in People With Refractory Cancers

31 enrolled 20 charts

Metastatic Solid Tumors

NCT05715281 2025-11-25

Testing the Combination of Anti-cancer Drugs Atezolizumab and Tiragolumab in People With Advanced Stage Rare Cancers, RARE3 Trial

12 enrolled

Advanced Rare Malignant Solid Neoplasm

NCT02631733 2025-02-10

Liposomal Irinotecan and Veliparib in Treating Patients With Solid Tumors

18 enrolled

Malignant Solid Neoplasm

NCT04840615 2024-02-02

Intratumor Injection of Anti-Mesothelin Immunotoxin LMB-100 With Ipilimumab in Malignant Mesothelioma

2 enrolled 14 charts

MyeloidOther solid neoplasmThoracic

Mesothelioma

NCT05375825 2024-02-02

Phase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants With Pleural Mesotheliomas, or Pleural Effusions From Cancers Expressing Mesothelin

Phase 1 Withdrawn

Myeloproliferative Disorder, Chronic, with Eosinophilia, Mesothelioma, Malignant, Carcinoma, Pleural Effusion, Malignant

NCT03253679 2023-10-17

AZD1775 in Treating Patients With Advanced Refractory Solid Tumors With CCNE1 Amplification

31 enrolled 13 charts

Advanced Malignant Solid Neoplasm

NCT01827384 2023-09-29

MPACT Study to Compare Effects of Targeted Drugs on Tumor Gene Variations

208 enrolled 27 charts

Advanced Malignant Solid Neoplasm

NCT03233724 2023-05-31

Oral Decitabine and Tetrahydrouridine as Epigenetic Priming for Pembrolizumab-Mediated Immune Checkpoint Blockade in Patients With Inoperable, or Unresectable Locally Advanced or Metastatic Non-Small Cell Lung Cancers and Esophageal Carcinomas

Phase 1/2 Terminated

9 enrolled 14 charts

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Lung Neoplasms

NCT02798536 2022-08-23

Mesothelin-Targeted Immunotoxin LMB-100 in People With Malignant Mesothelioma

21 enrolled 19 charts

GastrointestinalGenitourinaryOther solid neoplasmSarcomaThoracic

Mesothelioma

NCT02859415 2022-04-05

Continuous 24h Intravenous Infusion of Mithramycin, an Inhibitor of Cancer Stem Cell Signaling, in People With Primary Thoracic Malignancies or Carcinomas, Sarcomas or Germ Cell Neoplasms With Pleuropulmonary Metastases

Phase 1/2 Terminated

3 enrolled 10 charts

Esophageal Neoplasms, Kidney Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasms, Germ Cell and Embryonal, Sarcoma, Thymus Neoplasms, Colorectal Neoplasms

NCT03644550 2021-12-02

Anti-Mesothelin Immunotoxin LMB-100 Followed by Pembrolizumab in Malignant Mesothelioma

Phase 2 Terminated

18 enrolled 15 charts

Mesothelioma

NCT01748825 2021-07-26

AZD1775 for Advanced Solid Tumors

67 enrolled 24 charts

Solid Tumors

NCT03531840 2021-04-09

Olaparib in People With Malignant Mesothelioma

23 enrolled 16 charts

BreastGynecologicOther solid neoplasm

Mesothelioma

NCT01989546 2021-02-23

Pilot Trial of BMN 673, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Deleterious BRCA Mutations

Phase 1/2 Completed

9 enrolled 11 charts

Advanced Ovarian Cancer

NCT01143545 2020-03-03

Pilot Study of Allogeneic Tumor Cell Vaccine With Metronomic Oral Cyclophosphamide and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers, Thymic Neoplasms, and Malignant Pleural Mesotheliomas

GastrointestinalOther solid neoplasmSarcomaThoracic

10 enrolled

Mesothelioma, Malignant, Esophageal Neoplasms, Lung Neoplasms, Sarcoma, Thymoma

NCT01624090 2019-12-30

Mithramycin for Lung, Esophagus, and Other Chest Cancers

Phase 2 Terminated

16 enrolled 13 charts

BreastGastrointestinalOther solid neoplasmThoracic

Breast Neoplasms, Esophageal Neoplasms, Gastrointestinal Neoplasms, Lung Neoplasms, Mesothelioma

NCT01413451 2019-12-17

Amatuximab for High Mesothelin Cancers

Phase EARLY_PHASE1 Terminated

7 enrolled

GastrointestinalGynecologicOther solid neoplasmThoracic

Carcinoma, Non-Small-Cell Lung, Mesothelioma, Ovarian Neoplasms, Carcinoma, Pancreatic Ductal

NCT00094978 2019-12-12

Depsipeptide/Flavopiridol Infusion for Cancers of the Lungs, Esophagus, Pleura, Thymus or Mediastinum

23 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Mesothelioma, Carcinoma, Small Cell, Small Cell Lung Carcinoma

NCT01258868 2019-12-03

Tumor Cell Vaccines With ISCOMATRIX Adjuvant and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers and Malignant Pleural Mesotheliomas

44 enrolled

Esophageal Neoplasms, Lung Neoplasms, Mesothelioma, Thymoma

NCT03436732 2019-11-22

Mesothelin-Targeted Immunotoxin LMB-100 in Combination With SEL-110 in Subjects With Malignant Pleural or Peritoneal Mesothelioma

5 enrolled 12 charts

GastrointestinalGynecologicOther solid neoplasmThoracic

Mesothelioma

NCT01583686 2019-10-14

CAR T Cell Receptor Immunotherapy Targeting Mesothelin for Patients With Metastatic Cancer

Phase 1/2 Terminated

15 enrolled 14 charts

Uterine Cervical Neoplasms, Lung Neoplasms, Mesothelioma, Neoplasm Metastasis, Ovarian Neoplasms, Pancreatic Neoplasms

NCT00037817 2019-09-30

Phase I Study of Gene Induction Mediated by Sequential Decitabine/Depsipeptide Infusion With or Without Concurrent Celecoxib in Subjects With Pulmonary and Pleural Malignancies

34 enrolled

Mesothelioma, Malignant, Carcinoma, Non-Small-Cell Lung, Lung Neoplasms, Small Cell Lung Carcinoma

NCT01362790 2019-06-06

SS1P and Pentostatin Plus Cyclophosphamide for Mesothelioma

Phase 1/2 Completed

55 enrolled 22 charts

Adenocarcinoma of Lung, Mesothelioma, Pancreatic Neoplasms

NCT01445392 2018-08-03

SS1(dsFV)PE38 Plus Pemetrexed and Cisplatin to Treat Malignant Pleural Mesothelioma

24 enrolled

Mesothelioma, Malignant, Mesothelioma

NCT00365053 2018-06-07

PXD101 as Second-Line Therapy in Treating Patients With Malignant Mesothelioma of the Chest That Cannot Be Removed By Surgery

13 enrolled 7 charts

Mesothelioma, Malignant, Solitary Fibrous Tumor, Pleural

NCT01160458 2018-04-10

Phase II Study of IMC-A12 in Patients With Mesothelioma Who Have Been Previously Treated With Chemotherapy

20 enrolled 12 charts

Mesothelioma, Malignant

NCT00243074 2018-01-23

S0509 - AZD2171 in Treating Patients With Malignant Pleural Mesothelioma That Cannot Be Removed By Surgery

54 enrolled 12 charts

BreastGastrointestinalGynecologicHead & NeckOther solid neoplasmThoracic

Mesothelioma, Malignant, Solitary Fibrous Tumor, Pleural

NCT02567396 2017-04-24

Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be Removed by Surgery and Liver or Kidney Dysfunction

Phase 1 Withdrawn

Squamous Cell Carcinoma of Head and Neck, Carcinoma, Non-Small-Cell Lung, Mesothelioma, Ovarian Neoplasms, Stomach Neoplasms, Small Cell Lung Carcinoma, Triple Negative Breast Neoplasms

NCT01861301 2016-10-24

Tivantinib in Treating Patients With Previously Treated Malignant Mesothelioma

Phase 2 Terminated

18 enrolled 7 charts

Mesothelioma, Malignant, Solitary Fibrous Tumor, Pleural

NCT00019565 2016-09-26

PET and/or MRI Scans in Assessing Tumor Response in Patients Receiving Antiangiogenesis Therapy

53 enrolled

Unspecified Adult Solid Tumor, Protocol Specific

NCT00004547 2015-11-18

Treatment of Peritoneal Cancer With Surgery, Perfused Heated Cisplatin and Chemotherapy

GastrointestinalGynecologicOther solid neoplasmThoracic

188 enrolled 11 charts

Abdominal Neoplasms, Colonic Neoplasms, Mesothelioma, Peritoneal Neoplasms

NCT00245076 2015-05-01

Smokefree.Gov Website in Helping United States Federal Employees Quit Smoking

Phase NA Completed

Unspecified Adult Solid Tumor, Protocol Specific

NCT00006981 2015-04-30

Immunotoxin Therapy in Treating Patients With Advanced Cancer