Announcements Trials
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Phase

Phase NA 1Phase 4 1Phase 2 1

Status

Not yet recruiting 1Enrolling by invitation 1Completed 1

Sponsor Class

OTHER 1NIH 1INDUSTRY 1

Study Type

Interventional 3

Sponsor

Cancer Type

Plasma cell 3Other hematologic neoplasm 3Lymphoid 3

Conditions

Multiple Myeloma 235Lymphoma 30Hematologic Neoplasms 21Recurrence 18Neoplasms 14Neoplasms, Plasma Cell 13Lymphoma, Non-Hodgkin 13Immunoglobulin Light-chain Amyloidosis 13Leukemia, Lymphocytic, Chronic, B-Cell 12Leukemia, Myeloid, Acute 10Lymphoma, Mantle-Cell 9Smoldering Multiple Myeloma 8Prostatic Neoplasms 8Precursor Cell Lymphoblastic Leukemia-Lymphoma 8Myelodysplastic Syndromes 8Lymphoma, Large B-Cell, Diffuse 8Hodgkin Disease 8Ovarian Neoplasms 6Lung Neoplasms 6Leukemia, Plasma Cell 6Breast Neoplasms 6Waldenstrom Macroglobulinemia 5Melanoma 5Lymphoma, Follicular 5Monoclonal Gammopathy of Undetermined Significance 4Lymphoma, B-Cell, Marginal Zone 4Leukemia, Myelogenous, Chronic, BCR-ABL Positive 4Leukemia 4Colorectal Neoplasms 4Carcinoma, Non-Small-Cell Lung 4

Interventions

tocilizumab 1siltuximab 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

3 trials
RecentStart dateEnrollment
Cytokine Release Syndrome × Plasma cell × 30 days × Clear all
NCT04975555 2026-06-03

Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy

University of Alabama at Birmingham

Phase 2 Completed
24 enrolled 8 charts
LymphoidOther hematologic neoplasmPlasma cell

Cytokine Release Syndrome, Lymphoma, Lymphoma, Non-Hodgkin, Multiple Myeloma, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT07499128 2026-06-01

Continuous Temperature Monitoring (CTM) for Cytokine Release Syndrome (CRS), an Immune-Related Adverse Event

National Institutes of Health Clinical Center (CC)

Phase NA Enrolling by invitation
136 enrolled
LymphoidOther hematologic neoplasmPlasma cell

Cytokine Release Syndrome, Lymphoma, Multiple Myeloma, Neoplasms, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT07609940 2026-05-27

POPLIN

Regeneron Pharmaceuticals

Phase 4 Not yet recruiting
30 enrolled
Plasma cell

Cytokine Release Syndrome, Multiple Myeloma

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