Announcements Trials
Browse Landscape

Phase

Phase 2 5Phase NA 2Phase 4 1

Status

Recruiting 3Withdrawn 1Completed 1

Sponsor Class

OTHER 5

Study Type

Interventional 5

Sponsor

Cancer Type

Plasma cell 5Lymphoid 5Other hematologic neoplasm 1

Conditions

Multiple Myeloma 1086Neoplasms, Plasma Cell 255Lymphoma 157Lymphoma, Non-Hodgkin 150Hodgkin Disease 135Recurrence 130Leukemia, Lymphocytic, Chronic, B-Cell 130Precursor Cell Lymphoblastic Leukemia-Lymphoma 116Myelodysplastic Syndromes 111Leukemia 109Leukemia, Myeloid, Acute 106Lymphoma, Follicular 84Lymphoma, Mantle-Cell 83Lymphoma, B-Cell, Marginal Zone 82Burkitt Lymphoma 76Lymphoma, Large B-Cell, Diffuse 74Myeloproliferative Disorders 70Immunoglobulin Light-chain Amyloidosis 67Lymphoma, Large-Cell, Immunoblastic 65Hematologic Neoplasms 63Primary Myelofibrosis 58Leukemia, Myeloid, Chronic-Phase 57Leukemia, Myeloid, Accelerated Phase 51Leukemia, Myelogenous, Chronic, BCR-ABL Positive 49Waldenstrom Macroglobulinemia 46Blast Crisis 44Congenital Abnormalities 43Leukemia, Myelomonocytic, Chronic 42Dendritic Cell Sarcoma, Interdigitating 42Smoldering Multiple Myeloma 41

Interventions

siltuximab 3tocilizumab 1talquetamab 1Dexamethasone 1Calcium Dobesilate 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

5 trials
RecentStart dateEnrollment
Phase 2 × Cytokine Release Syndrome × Plasma cell × Clear all
NCT04975555 2026-06-03

Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy

University of Alabama at Birmingham

Phase 2 Completed
24 enrolled 8 charts
LymphoidOther hematologic neoplasmPlasma cell

Cytokine Release Syndrome, Lymphoma, Lymphoma, Non-Hodgkin, Multiple Myeloma, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT06421675 2026-04-27

EMBRACE

Ontario Clinical Oncology Group (OCOG)

Phase 2 Recruiting
40 enrolled
Plasma cell

Cytokine Release Syndrome, Multiple Myeloma, Recurrence

NCT05972135 2026-04-22

Outpatient Administration of Teclistamab or Talquetamab for Multiple Myeloma

SCRI Development Innovations, LLC

Phase 2 Recruiting
100 enrolled
Plasma cell

Cytokine Release Syndrome, Multiple Myeloma

NCT07106671 2025-08-06

A Phase II Study of Siltuximab for CRS/ICANs After CAR-T in Multiple Myeloma

Institute of Hematology & Blood Diseases Hospital, China

Phase 2 Recruiting
20 enrolled
Plasma cell

Cytokine Release Syndrome, Neoplasms, Plasma Cell

NCT06352866 2025-03-03

Siltuximab for Cytokine Release Syndrome Prophylaxis Prior to tx w/ Teclistamab in RRMM

Case Comprehensive Cancer Center

Phase 2 Withdrawn
Plasma cell

Cytokine Release Syndrome, Multiple Myeloma

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