Clinical Trials

Astrocytoma, Brain Neoplasms, Glioblastoma, Recurrence, Gliosarcoma

NCT02052648 2024-03-27

Study of IDO Inhibitor and Temozolomide for Adult Patients With Primary Malignant Brain Tumors

Phase 1/2 Completed

160 enrolled 21 charts

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00387400 2023-08-04

Temozolomide + Everolimus in Newly Diagnosed, Recurrent, or Progressive Malignant Glioblastoma Multiforme

32 enrolled

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT02661282 2023-06-18

Autologous CMV-Specific Cytotoxic T Cells and Temozolomide in Treating Patients With Glioblastoma

Phase 1/2 Completed

65 enrolled 21 charts

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT02573324 2023-05-11

Intellance1

Phase 3 Completed

691 enrolled 28 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT01110876 2021-08-25

Phase I / II Vorinostat, Erlotinib and Temozolomide for Recurrent Glioblastoma Multiforme (GBM)

Phase 1/2 Terminated

21 enrolled 8 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT01740258 2021-01-26

BBP

68 enrolled 11 charts

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT02502708 2020-06-04

Study of the IDO Pathway Inhibitor, Indoximod, and Temozolomide for Pediatric Patients With Progressive Primary Malignant Brain Tumors

81 enrolled

Diffuse Intrinsic Pontine Glioma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Gliosarcoma

NCT00275067 2020-02-25

Arsenic Trioxide, Temozolomide, and Radiation Therapy in Treating Patients With Malignant Glioma That Has Been Removed By Surgery

Phase 1/2 Unknown

50 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT01164189 2019-02-28

TAVAREC

155 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00734526 2018-11-09

Phase I Portion of Phase I/II Sorafenib With Radiation and Temozolomide in Newly Diagnosed Glioblastoma or Gliosarcoma

Phase 1 Terminated

18 enrolled

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00433381 2018-09-17

Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or Gliosarcoma

123 enrolled 16 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00003176 2018-06-27

Temozolomide and Carmustine in Treating Patients With Anaplastic Glioma

82 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00006025 2018-06-27

Temozolomide Plus Irinotecan in Treating Patients With Recurrent Malignant Glioma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00027625 2018-06-27

Gefitinib Plus Temozolomide in Treating Patients With Malignant Primary Glioma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00006358 2018-06-26

Temozolomide Plus Thalidomide in Treating Patients With Recurrent or Progressive Brain Tumor

44 enrolled

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01390571 2018-02-05

Olaparib and Temozolomide in Treating Patients With Relapsed Glioblastoma

34 enrolled

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00619112 2018-01-31

Temozolomide in Treating Patients With Recurrent High-Grade Glioma

60 enrolled 9 charts

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT01480479 2018-01-16

ACT IV

Phase 3 Completed

745 enrolled

Brain Neoplasms, Glioblastoma, Neoplasms, Gliosarcoma

NCT00086879 2017-07-27

Erlotinib Compared With Temozolomide or Carmustine in Treating Patients With Recurrent Glioblastoma Multiforme

110 enrolled

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT01026493 2017-07-02

Veliparib and Temozolomide in Treating Patients With Recurrent Glioblastoma

Phase 1/2 Completed

257 enrolled 16 charts

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00883298 2017-03-30

Bi-weekly Temozolomide Plus Bevacizumab for Adult Patients With Recurrent Glioblastoma Multiforme

30 enrolled

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00436436 2017-03-28

O(6)-Benzylguanine and Temozolomide in Treating Patients With Glioblastoma Multiforme That Did Not Respond to Previous Temozolomide and Radiation Therapy

Phase 2 Terminated

12 enrolled 10 charts

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00498927 2016-02-29

Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma

47 enrolled 7 charts

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Glioma, Subependymal, Gliosarcoma

NCT02599090 2015-11-06

Phase II Sorafenib With Radiation and Temozolomide in Newly Diagnosed Glioblastoma or Gliosarcoma

Phase 2 Withdrawn

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00083096 2015-02-10

Lonafarnib and Temozolomide in Treating Patients With Recurrent Primary Supratentorial Gliomas

Phase 1 Unknown

30 enrolled

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Glioma, Subependymal, Gliosarcoma

NCT00516607 2015-02-10

Enzastaurin and Temozolomide in Treating Patients With Primary Gliomas

Phase 1 Unknown

28 enrolled

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00005951 2014-08-22

Irinotecan Plus Temozolomide in Treating Patients With Recurrent Primary Malignant Glioma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00612989 2014-07-16

Ph I 5-day Temozolomide + O6-BG in Treatment of Pts w Recurrent / Progressive GBM

42 enrolled

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00650923 2014-05-30

Aflibercept, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Multiforme, Gliosarcoma, or Other Malignant Glioma

61 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00597402 2014-05-07

Avastin in Combination With Radiation (XRT) & Temozolomide, Followed by Avastin, Temozolomide and Irinotecan for Glioblastoma (GBM) and Gliosarcomas

125 enrolled 9 charts

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00052455 2013-12-18

Temozolomide Compared to Procarbazine, Lomustine, and Vincristine in Treating Patients With Recurrent Malignant Glioma

Phase 3 Completed

500 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00014105 2013-12-04

Combination Chemotherapy in Treating Patients With Recurrent Glioblastoma Multiforme

Phase 1/2 Unknown

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00610571 2013-10-25

Ph I Oral Topotecan and Temozolomide for Patients With Malignant Gliomas

62 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00613028 2013-07-16

Ph II Bev + Either Temozolomide/Etoposide for GBM Pts Who Have Failed Bev + Irinotecan

23 enrolled 10 charts

Brain Neoplasms, Glioblastoma, Gliosarcoma

NCT00021307 2013-07-11

Temozolomide Plus Carboplatin in Treating Patients With Recurrent Glioblastoma Multiforme

Phase 1/2 Withdrawn

Brain Neoplasms, Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00597493 2013-06-24

Ph. 2 Sorafenib + Protracted Temozolomide in Recurrent GBM

32 enrolled 9 charts

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00006474 2013-06-20

Temozolomide and O6-benzylguanine in Treating Patients With Newly Diagnosed, Recurrent, or Progressive Anaplastic Glioma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00004113 2013-06-19

Temozolomide in Treating Patients With Recurrent Malignant Glioma

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00612339 2013-05-27

Avastin in Combination With Temozolomide for Unresectable or Multifocal GBMs and Gliosarcomas

41 enrolled 7 charts

Brain Neoplasms, Glioblastoma, Glioma, Gliosarcoma

NCT00354068 2013-03-28

Imatinib Mesylate and Temozolomide in Treating Patients With Malignant Glioma

65 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Central Nervous System Neoplasms, Gliosarcoma

NCT00612651 2013-02-20

PH I Addition of Farnesyl Transferase Inhibitor to Temozolomide for Pts w Gr 3 & 4 Malignant Gliomas

37 enrolled

Astrocytoma, Brain Neoplasms, Glioblastoma, Glioma, Oligodendroglioma, Gliosarcoma

NCT00544284 2013-02-15

Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment

25 enrolled

CNSLymphoidSarcoma

Astrocytoma, Brain Neoplasms, Craniopharyngioma, Ependymoma, Glioblastoma, Glioma, Lymphoma, Medulloblastoma, Meningioma, Neoplasm Metastasis, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Gliosarcoma

NCT00025558 2011-03-28

Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Brain Cancer

CNSLymphoidOther hematologic neoplasmSarcoma

Familial ependymoma, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Medulloblastoma, Oligodendroglioma, Pinealoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00003567 2010-06-11

Gene Therapy and Chemotherapy in Treating Patients With Advanced Solid Tumors or Non-Hodgkin's Lymphoma

Phase 1 Terminated

8 enrolled

Astrocytoma, Brain Neoplasms, Burkitt Lymphoma, Ependymoma, Glioblastoma, Glioma, Lymphoma, Lymphoma, Follicular, Lymphoma, Non-Hodgkin, Oligodendroglioma, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, Large-Cell, Immunoblastic, Lymphoma, Large B-Cell, Diffuse, Central Nervous System Neoplasms, Neuroectodermal Tumors, Primitive, Glioma, Subependymal, Gliosarcoma, Lymphoma, B-Cell, Marginal Zone, Lymphoma, Mantle-Cell, Precursor Cell Lymphoblastic Leukemia-Lymphoma

NCT00365222 2009-01-22

Phase II Study of Temozolomide in Newly Diagnosed Glioblastoma

Phase 2 Terminated

1 enrolled