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Phase

Phase EARLY_PHASE1 1Phase 1/2 1

Status

Completed 1Active not recruiting 1

Sponsor Class

OTHER 2

Study Type

Interventional 2

Sponsor

Cancer Type

Sarcoma 2

Conditions

Sarcoma 26Glioblastoma 25Gliosarcoma 22Rhabdomyosarcoma 21Sarcoma, Ewing 18Glioma 15Brain Neoplasms 14Astrocytoma 13Neuroblastoma 12Central Nervous System Neoplasms 12Oligodendroglioma 9Osteosarcoma 8Neoplasms 7Medulloblastoma 6Pancreatic Neoplasms 5Neuroectodermal Tumors, Primitive, Peripheral 5Neoplasm Metastasis 5Breast Neoplasms 5Colorectal Neoplasms 4Bone Neoplasms 4Stomach Neoplasms 3Recurrence 3Optic Nerve Glioma 3Malignant mesenchymal tumor 3Diffuse Intrinsic Pontine Glioma 3Colonic Neoplasms 3Wilms Tumor 2Triple Negative Breast Neoplasms 2Small Cell Lung Carcinoma 2Rhabdoid Tumor 2

Interventions

Cyclophosphamide 9Doxorubicin 8Vincristine 6Etoposide 6Ifosfamide 5Filgrastim 5Radiotherapy 4fludarabine phosphate 3Topotecan 3Thiotepa 3Peripheral Blood Stem Cell Transplantation 3Melphalan 3Cisplatin 3Carboplatin 3seclidemstat 2Temozolomide 2Tacrolimus 2Neoadjuvant Therapy 2Irinotecan 2Injections 2Hyperthermic Intraperitoneal Chemotherapy 2Granulocyte Colony-Stimulating Factor 2Epirubicin 2Dactinomycin 2Cytoreduction Surgical Procedures 2Cyclosporine 2Chemotherapy, Adjuvant 2Brachytherapy 2thymoglobulin 1tazemetostat 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Desmoplastic Small Round Cell Tumor × Irinotecan × Sarcoma × Clear all
NCT01189643 2025-09-05

Irinotecan, Temozolomide and Bevacizumab in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Newly Diagnosed Patients With Desmoplastic Small Round Cell Tumor

Memorial Sloan Kettering Cancer Center

Phase EARLY_PHASE1 Active not recruiting
15 enrolled
Sarcoma

Sarcoma, Desmoplastic Small Round Cell Tumor

NCT04095221 2025-02-20

A Study of the Drugs Prexasertib, Irinotecan, and Temozolomide in People With Desmoplastic Small Round Cell Tumor and Rhabdomyosarcoma

Memorial Sloan Kettering Cancer Center

Phase 1/2 Completed
21 enrolled
Sarcoma

Rhabdomyosarcoma, Desmoplastic Small Round Cell Tumor

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