Announcements Trials
Browse Landscape

Phase

Phase 2 2

Status

Terminated 1Active not recruiting 1

Sponsor Class

NIH 2

Study Type

Interventional 2

Sponsor

Cancer Type

Endocrine 19CNS 16NET 6Gastrointestinal 5Genitourinary 4Head & Neck 3Sarcoma 2Thoracic 1Myeloid 1Lymphoid 1Dermatologic 1

Conditions

Sarcoma 286Gliosarcoma 149Glioblastoma 149Brain Neoplasms 90Osteosarcoma 84Glioma 68Gastrointestinal Stromal Tumors 68Rhabdomyosarcoma 65Lymphoma, Non-Hodgkin 59Astrocytoma 59Recurrence 57Dendritic Cell Sarcoma, Interdigitating 57Sarcoma, Ewing 55Neoplasms 54Precursor Cell Lymphoblastic Leukemia-Lymphoma 50Lymphoma 50Burkitt Lymphoma 49Central Nervous System Neoplasms 48Neuroblastoma 47Lymphoma, Large B-Cell, Diffuse 47Lymphoma, Follicular 46Neoplasm Metastasis 45Lymphoma, Mantle-Cell 45Leiomyosarcoma 44Oligodendroglioma 43Leukemia, Myeloid, Acute 43Liposarcoma 42Lymphoma, B-Cell, Marginal Zone 41Leukemia, Lymphocytic, Chronic, B-Cell 41Hodgkin Disease 41

Interventions

tipifarnib 1guadecitabine 1

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

2 trials
RecentStart dateEnrollment
Has results × Pheochromocytoma × Sarcoma × Clear all
NCT04284774 2026-05-27

Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial

National Cancer Institute (NCI)

Phase 2 Active not recruiting
5 enrolled 9 charts
CNSDermatologicEndocrineGastrointestinalGenitourinaryHead & NeckLymphoidMyeloidSarcoma

Ependymoma, Glioma, Histiocytosis, Langerhans-Cell, Lymphoma, Non-Hodgkin, Medulloblastoma, Melanoma, Wilms Tumor, Neuroblastoma, Pheochromocytoma, Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Thyroid Neoplasms, Hepatoblastoma, Neuroectodermal Tumors, Primitive, Peripheral, Rhabdoid Tumor

NCT03165721 2026-02-18

A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase Deficiency and HLRCC-associated Kidney Cancer

National Institutes of Health Clinical Center (CC)

Phase 2 Terminated
9 enrolled 11 charts
CNSEndocrineGastrointestinalGenitourinarySarcoma

Carcinoma, Renal Cell, Kidney Neoplasms, Paraganglioma, Pheochromocytoma, Gastrointestinal Stromal Tumors

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