Clinical Trials

Osteosarcoma

NCT07321912 2026-05-26

Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

Phase 2 Recruiting

406 enrolled

Phase 1 Active not recruiting

Sarcoma, Ewing, Osteosarcoma

NCT04521686 2026-04-22

Study of LY3410738 Administered to Patients With Advanced Solid Tumors With IDH1 or IDH2 Mutations

200 enrolled

BreastCNSDermatologicGastrointestinalGenitourinaryHead & NeckSarcoma

Breast Neoplasms, Chondrosarcoma, Colonic Neoplasms, Glioblastoma, Glioma, Melanoma, Prostatic Neoplasms, Thyroid Neoplasms, Central Nervous System Neoplasms, Cholangiocarcinoma

NCT03965234 2026-03-17

Pulmonary Suffusion in Controlling Minimal Residual Disease in Patients With Sarcoma or Colorectal Metastases

Phase 1/2 Recruiting

99 enrolled

GastrointestinalSarcoma

Bone Neoplasms, Sarcoma, Colorectal Neoplasms

NCT07477457 2026-03-17

A Study of Gefitinib, Trametinib, Disulfiram, and Sunitinib in Addition to Standard Chemotherapy in People With Osteosarcoma

Phase 2 Recruiting

45 enrolled

BreastGastrointestinalSarcoma

Neoplasm Metastasis, Osteosarcoma

NCT02784795 2025-08-21

A Study of LY3039478 in Participants With Advanced or Metastatic Solid Tumors

Phase 1 Terminated

94 enrolled 28 charts

Breast Neoplasms, Colonic Neoplasms, Sarcoma, Cholangiocarcinoma

NCT00470223 2025-06-08

OS2006

Phase 3 Active not recruiting

318 enrolled

Phase EARLY_PHASE1 Terminated

Sarcoma, Osteosarcoma

NCT04213794 2025-02-20

TOASTIT

2 enrolled

GastrointestinalGynecologicOther solid neoplasmSarcomaThoracic

Mesothelioma, Malignant, Colonic Neoplasms, Fallopian Tube Neoplasms, Liposarcoma, Ovarian Neoplasms, Pelvic Neoplasms, Rectal Neoplasms, Rhabdomyosarcoma, Sarcoma, Stomach Neoplasms, Desmoplastic Small Round Cell Tumor

NCT03809637 2024-12-18

A Study of Pemetrexed Plus Cisplatin in Patients With Refractory Soft Tissue Sarcoma

37 enrolled

GastrointestinalHead & NeckSarcomaThoracic

NCT04999761 2024-09-25

AB122 Platform Study

Phase 1 Recruiting

917 enrolled

Biliary Tract Neoplasms, Carcinoma, Non-Small-Cell Lung, Esophageal Neoplasms, Head and Neck Neoplasms, Neoplasm Metastasis, Stomach Neoplasms, Colorectal Neoplasms, Sarcoma, Alveolar Soft Part

NCT03277924 2024-08-13

ImmunoSarc

Phase 1/2 Completed

197 enrolled

Chondrosarcoma, Extraskeletal Myxoid, Bone Neoplasms, Chondrosarcoma, Hemangioendothelioma, Hemangiosarcoma, Leiomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Sarcoma, Synovial, Sarcoma, Clear Cell, Sarcoma, Alveolar Soft Part, Hemangioendothelioma, Epithelioid, Histiocytoma, Malignant Fibrous, Solitary Fibrous Tumors

NCT01459484 2024-05-20

ISG/OS-2

225 enrolled

Osteosarcoma

NCT05057130 2024-04-01

Neoadjuvant Combination of Doxorubicin, Cisplatin and Methotrexate in Patients Aged 24-40 Years With Primary Bone Tumors

Phase 2/3 Unknown

50 enrolled

Bone Neoplasms, Neoplasms, Connective Tissue, Sarcoma, Osteosarcoma, Neoplasms, Connective and Soft Tissue

NCT02897375 2023-10-10

Palbociclib With Cisplatin or Carboplatin in Advanced Solid Tumors

BreastGastrointestinalGenitourinaryGynecologicHead & NeckSarcomaThoracic

71 enrolled

Urinary Bladder Neoplasms, Breast Neoplasms, Carcinoma, Non-Small-Cell Lung, Head and Neck Neoplasms, Ovarian Neoplasms, Pancreatic Neoplasms, Sarcoma, Colorectal Neoplasms

NCT01998529 2023-09-14

Study of Cytoreductive Surgery and Hyperthermic Intrathoracic Pleural Chemotherapy (HITC) With Escalating Doses for Children and Adolescents With Unilateral Pleural Malignancy

7 enrolled

SarcomaThoracic

Lung Neoplasms, Sarcoma

NCT03912818 2023-09-11

Durvalumab and Standard Chemotherapy Before Surgery in Treating Patients With Variant Histology Bladder Cancer

7 enrolled 9 charts

GenitourinarySarcoma

Bladder Adenocarcinoma

NCT00667342 2023-08-07

A Study of Bevacizumab in Combination With Chemotherapy for Treatment of Osteosarcoma

43 enrolled 25 charts

Classical hematologySarcomaThoracic

Osteosarcoma, Histiocytoma, Malignant Fibrous

NCT02797977 2023-06-22

A Phase 1/2 Trial SRA737 in Combination With Gemcitabine and Cisplatin or Gemcitabine Alone in Advanced Cancer Subjects

Phase 1/2 Completed

153 enrolled

Fanconi Anemia, Sarcoma, Small Cell Lung Carcinoma

NCT00134030 2023-06-07

EURAMOS-1

Phase 3 Completed

1,334 enrolled 17 charts

Osteosarcoma

NCT04861948 2022-10-04

IBI188 Combination Therapy in Solid Tumors

Phase 1 Terminated

9 enrolled

SarcomaThoracic

Adenocarcinoma of Lung, Osteosarcoma

NCT01014598 2022-07-25

Cisplatin in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer or Lung Metastasis

11 enrolled

SarcomaThoracic

Carcinoma, Non-Small-Cell Lung, Sarcoma

NCT03909776 2021-01-05

Transcatheter Intra-arterial Limb Infusion of Cisplatin for Extremity Osteosarcoma

Phase NA Completed

99 enrolled

Osteosarcoma

NCT00498979 2020-07-24

Sodium Stibogluconate and IFNa-2b Followed By CDDP, VLB and DTIC Treating Pts.With Advanced Melanoma or Other Cancers

22 enrolled

CNSDermatologicSarcoma

Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Melanoma, Oligodendroglioma, Glioma, Subependymal, Gliosarcoma

NCT01277744 2020-01-13

Pilot Study of Hyperthermic Peritoneal Perfusion (HIPEC) for Adolescent and Young Adults With Desmoplastic Small Round Cell Tumor

22 enrolled 7 charts

GenitourinarySarcoma

Wilms Tumor, Sarcoma, Desmoplastic Small Round Cell Tumor

NCT01099358 2019-09-26

Study in Advanced Solid Tumors

47 enrolled 15 charts

Head & NeckSarcoma

Carcinoma, Head and Neck Neoplasms, Sarcoma

NCT01650090 2019-08-07

Phase 2 Study of Inhaled Lipid Cisplatin in Pulmonary Recurrent Osteosarcoma

28 enrolled

Osteosarcoma

NCT03360760 2018-08-28

Timing of Surgery in Nonmetastatic Osteosarcoma of the Pelvis and Sacrum

Phase NA Unknown

100 enrolled

Osteosarcoma

NCT00703638 2017-11-29

Sorafenib, Pemetrexed, and Cisplatin in Treating Patients With Advanced Solid Tumors

BreastGastrointestinalGenitourinaryHead & NeckOther solid neoplasmSarcomaThoracic

16 enrolled

Breast Neoplasms, Head and Neck Neoplasms, Lung Neoplasms, Mesothelioma, Pancreatic Neoplasms, Prostatic Neoplasms, Sarcoma, Colorectal Neoplasms

NCT00002601 2017-03-03

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Sarcoma

13 enrolled 8 charts

Rhabdomyosarcoma, Sarcoma, Osteosarcoma, Neuroectodermal Tumors, Primitive, Peripheral

NCT00002492 2016-12-15

Combination Chemotherapy in Treating Patients With Soft Tissue Sarcoma

NCT00003996 2016-12-07

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

93 enrolled

CNSSarcoma

Glioblastoma, Central Nervous System Neoplasms, Gliosarcoma

NCT00002546 2016-02-11

Radiation Therapy Compared With Combination Chemotherapy in Treating Patients With Cancer of the Uterus

Phase 3 Completed

216 enrolled

NCT00586846 2016-01-20

Phase II Study of Chemotherapy and Pamidronate for the Treatment of Newly Diagnosed Osteosarcoma

40 enrolled 6 charts

CNSOther solid neoplasmSarcoma

Osteosarcoma

NCT00003273 2015-12-03

Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor

Phase 2 Withdrawn

Neuroblastoma, Retinoblastoma, Sarcoma, Central Nervous System Neoplasms, Choroid Plexus Neoplasms

NCT00002854 2015-08-26

High-Dose Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Advanced Cancer

BreastDermatologicGastrointestinalGenitourinaryGynecologicSarcoma

33 enrolled

Carcinoma, Ovarian Epithelial, Anus Neoplasms, Bile Duct Neoplasms, Breast Neoplasms, Colonic Neoplasms, Esophageal Neoplasms, Gallbladder Neoplasms, Carcinoma, Hepatocellular, Melanoma, Neoplasms, Wilms Tumor, Pancreatic Neoplasms, Rectal Neoplasms, Sarcoma, Osteosarcoma, Stomach Neoplasms, Neuroectodermal Tumors, Primitive, Peripheral

NCT00019864 2015-06-08

Combination Chemotherapy Before and After Surgery in Treating Patients With Osteosarcoma

100 enrolled

Sarcoma, Osteosarcoma, Cardiotoxicity

NCT00673179 2014-09-10

Doxorubicin With Cisplatin, High-Dose Methotrexate, and Additional Risk-Adapted Outpatient Chemotherapy

Phase NA Terminated

7 enrolled 3 charts

Osteosarcoma

NCT00003937 2014-08-05

Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma

Phase 3 Completed

253 enrolled

Sarcoma, Cardiotoxicity

NCT00742924 2014-07-04

Zoledronic Acid and Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma

24 enrolled 9 charts

Sarcoma, Osteosarcoma

NCT00003141 2014-03-28

Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors

94 enrolled

CNSSarcoma

Astrocytoma, Brain Neoplasms, Neuroblastoma, Sarcoma, Spinal Cord Neoplasms, Central Nervous System Neoplasms, Choroid Plexus Neoplasms, Rhabdoid Tumor

NCT01258634 2013-12-10

A Study of Pre-Operative Treatment of Newly-Diagnosed, Surgically-Resectable Osteosarcoma With Doxorubicin, Ifosfamide, Etoposide, and Cisplatin With Early Metabolic Assessment of Response

Phase 1 Terminated

2 enrolled

Osteosarcoma

NCT00002608 2013-07-10

Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors

CNSEndocrineGastrointestinalHead & NeckOther solid neoplasmSarcomaThoracic

30 enrolled

Familial ependymoma, Thyroid Cancer, Papillary, Mesothelioma, Malignant, Astrocytoma, Brain Neoplasms, Ependymoma, Glioblastoma, Glioma, Head and Neck Neoplasms, Carcinoma, Hepatocellular, Liver Neoplasms, Medulloblastoma, Oligodendroglioma, Pheochromocytoma, Sarcoma, Thyroid Neoplasms, Central Nervous System Neoplasms, Adenocarcinoma, Follicular, Adrenocortical Carcinoma, Carcinoma, Medullary, Glioma, Subependymal, Gliosarcoma, Optic Nerve Glioma, Thyroid Carcinoma, Anaplastic

NCT00002993 2013-07-09

Combination Chemotherapy in Treating Patients With Recurrent or Advanced Cancer of the Uterus

30 enrolled

NCT00003776 2013-06-21

Combination Chemotherapy and Surgery in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma

Sarcoma, Osteosarcoma

NCT00003624 2013-04-11

Amifostine in Treating Women With Ovarian, Peritoneal, Cervical, Fallopian Tube, Uterine, or Endometrial Cancer

GynecologicSarcoma

Carcinoma, Ovarian Epithelial, Uterine Cervical Neoplasms, Fallopian Tube Neoplasms, Ovarian Neoplasms, Sarcoma, Endometrial Neoplasms, Neurotoxicity Syndromes

NCT00033644 2013-04-11

Combination Chemotherapy Plus Sargramostim in Treating Patients With Cancer of the Uterus

NCT00014573 2013-04-08

Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer