Clinical Trials

Phase 3 Active not recruiting

59 enrolled

CNSSarcoma

Neuroblastoma, Recurrence, Rhabdomyosarcoma

NCT02306161 2026-04-13

Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma

312 enrolled 14 charts

Phase 3 Active not recruiting

Sarcoma, Ewing

NCT02567435 2026-04-13

Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma

325 enrolled 14 charts

Rhabdomyosarcoma, Rhabdomyosarcoma, Alveolar, Rhabdomyosarcoma, Embryonal

NCT06541262 2026-04-09

Silmitasertib (CX-4945) in Combination With Chemotherapy for Relapsed Refractory Solid Tumors

104 enrolled

CNSSarcoma

Liposarcoma, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT04890093 2026-03-16

Vincristine and Temozolomide in Combination With PEN-866 for Adolescents and Young Adults With Relapsed or Refractory Solid Tumors

Phase 1/2 Suspended

64 enrolled

Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing

NCT07194044 2026-03-16

METTSEO

Phase 1 Recruiting

15 enrolled

Phase 3 Not yet recruiting

Sarcoma, Ewing

NCT07466316 2026-03-12

A Study Comparing Higher Dose Chemotherapy Over a Shorter Amount of Time to Lower Dose Chemotherapy Plus Maintenance Over a Longer Amount of Time in Patients With Newly Diagnosed Intermediate-Risk Rhabdomyosarcoma (IR RMS)

342 enrolled

Phase 2 Not yet recruiting

Rhabdomyosarcoma

NCT07444918 2026-03-03

Liposomal Irinotecan, Vincristine, Temozolomide, and Anlotinib for R/R Pediatric Solid Tumors

33 enrolled

Recurrence, Rhabdomyosarcoma, Sarcoma, Ewing, Osteosarcoma

NCT05304585 2026-02-24

Chemotherapy for the Treatment of Patients With Newly Diagnosed Very Low-Risk and Low Risk Fusion Negative Rhabdomyosarcoma

Phase 3 Recruiting

205 enrolled

Rhabdomyosarcoma, Embryonal

NCT04199026 2026-02-19

Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent Sarcoma

Phase NA Recruiting

20 enrolled

NCT06709495 2026-02-19

Phase 1/2 Trial to Evaluate the Safety and Efficacy of PEEL-224 in Combination With Vincristine and Temozolomide in Adolescents and Young Adults With Relapsed or Refractory Sarcomas

63 enrolled

Phase 3 Active not recruiting

Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Osteosarcoma, Desmoplastic Small Round Cell Tumor

NCT04994132 2026-02-17

A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarcoma

118 enrolled

Phase 2/3 Active not recruiting

Rhabdomyosarcoma, Rhabdomyosarcoma, Alveolar, Rhabdomyosarcoma, Embryonal

NCT06820957 2026-02-17

Testing a New Combination of Anti-cancer Drugs in Patients Newly Diagnosed With Ewing Sarcoma Who Have Cancer That Has Spread to Other Parts of the Body

437 enrolled

Sarcoma, Ewing

NCT01231906 2026-01-23

Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma

642 enrolled 11 charts

Phase 2 Not yet recruiting

Localized Extraskeletal Ewing Sarcoma

NCT07321912 2026-01-08

Eflornithine (DFMO) for Ewing Sarcoma and Osteosarcoma

406 enrolled

Sarcoma, Ewing, Osteosarcoma

NCT06220032 2026-01-05

HO170DLBCL

Phase 3 Recruiting

324 enrolled

Phase 2 Active not recruiting

Heart Failure, Lymphoma, Large B-Cell, Diffuse, Dendritic Cell Sarcoma, Interdigitating, Cardiotoxicity

NCT01871766 2025-12-17

Risk-Adapted Focal Proton Beam Radiation and/or Surgery in Patients With Low, Intermediate and High Risk Rhabdomyosarcoma Receiving Standard or Intensified Chemotherapy

115 enrolled

Phase 2 Active not recruiting

Rhabdomyosarcoma

NCT04388839 2025-11-26

Evolutionary Therapy for Rhabdomyosarcoma

12 enrolled

Phase 2 Active not recruiting

Rhabdomyosarcoma, Sarcoma

NCT00077285 2025-11-04

Irinotecan and Carboplatin as Upfront Window Therapy in Treating Patients With Newly Diagnosed Intermediate-Risk or High-Risk Rhabdomyosarcoma

65 enrolled

Malignant mesenchymal tumor, Rhabdomyosarcoma, Sarcoma

NCT06023641 2025-08-19

Treatment of Newly Diagnosed Rhabdomyosarcoma Using Molecular Risk Stratification and Liposomal Irinotecan Based Therapy in Children With Intermediate and High Risk Disease

Phase 2 Recruiting

135 enrolled

Phase 2 Not yet recruiting

Rhabdomyosarcoma

NCT07092306 2025-07-29

A Randomized Controlled Study Comparing the Safety and Efficacy of Irinotecan Hydrochloride Liposome Injection Combined With Temozolomide and Vincristine (NALIRI-VT) Versus Irinotecan Combined With Temozolomide and Vincristine (VIT) in Patients With Advanced Ewing's Sarcoma

74 enrolled

Sarcoma, Ewing

NCT01837862 2024-07-05

A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas

Phase 1/2 Completed

36 enrolled

CNSSarcoma

Diffuse Intrinsic Pontine Glioma, Astrocytoma, Glioblastoma, Glioma, Gliosarcoma, Optic Nerve Glioma

NCT04625907 2024-05-23

FaR-RMS

1,672 enrolled

Rhabdomyosarcoma

NCT02085148 2024-04-22

A Phase I Dose Finding Study in Children With Solid Tumors Recurrent or Refractory to Standard Therapy

CNSGastrointestinalGenitourinarySarcoma

62 enrolled

Neoplasms, Wilms Tumor, Neuroblastoma, Rhabdomyosarcoma, Sarcoma, Ewing, Hepatoblastoma

NCT00006734 2023-08-03

Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing's Sarcoma or Neuroectodermal Tumor

587 enrolled

Sarcoma, Neuroectodermal Tumors, Primitive, Peripheral

NCT03003520 2023-05-22

A Study of Durvalumab in Combination With R-CHOP or Lenalidomide Plus R-CHOP in Previously Untreated High-Risk Diffuse Large B-Cell Lymphoma

46 enrolled 20 charts

Lymphoma, Lymphoma, Large B-Cell, Diffuse, Dendritic Cell Sarcoma, Interdigitating

NCT00354835 2023-01-31

Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma

481 enrolled 21 charts

Rhabdomyosarcoma, Sarcoma

NCT03359005 2022-11-01

Irinotecan and Temozolomide for Ewing Sarcoma

Phase 2 Unknown

60 enrolled

Sarcoma, Ewing

NCT02531308 2022-09-28

DLBCL

Phase 2 Terminated

5 enrolled 5 charts

Lymphoma, Lymphoma, Large B-Cell, Diffuse, Dendritic Cell Sarcoma, Interdigitating

NCT02063022 2022-09-19

EW-1

278 enrolled

Sarcoma, Ewing

NCT02727387 2022-09-19

EW-2

155 enrolled

Sarcoma, Ewing

NCT00075582 2021-11-19

Vincristine, Dactinomycin, and Cyclophosphamide With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Low-Risk Rhabdomyosarcoma

390 enrolled 14 charts

Rhabdomyosarcoma

NCT00000987 2021-11-04

A Study of Chemotherapy Plus Azidothymidine in the Treatment of Kaposi's Sarcoma in Patients With AIDS

36 enrolled

Acquired Immunodeficiency Syndrome, Sarcoma, Kaposi, HIV Infections

NCT00000681 2021-11-03

A Phase I Study of the Combination of Recombinant GM-CSF, AZT, and Chemotherapy (ABV) (Adriamycin, Bleomycin, Vincristine) in AIDS and Kaposi's Sarcoma

24 enrolled

Acquired Immunodeficiency Syndrome, Sarcoma, Kaposi, HIV Infections

NCT00000954 2021-10-29

A Study of Chemotherapy Plus ddI or ddC in the Treatment of AIDS-Related Kaposi's Sarcoma

72 enrolled

Acquired Immunodeficiency Syndrome, Sarcoma, Kaposi, HIV Infections

NCT00038142 2020-01-29

Vincristine, Doxorubicin, Cyclophosphamide and Dexrazoxane (VACdxr) in High Risk Ewing's Sarcoma Patients

Phase 2 Terminated

46 enrolled 5 charts

Sarcoma, Ewing

NCT00354744 2020-01-29

High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma

109 enrolled 12 charts

Malignant mesenchymal tumor, Rhabdomyosarcoma, Sarcoma

NCT01222780 2020-01-18

To Evaluate the Safety, Activity and Pharmacokinetics of Marqibo in Children and Adolescents With Refractory Cancer

CNSGenitourinaryLymphoidOther hematologic neoplasmSarcoma

22 enrolled

Brain Neoplasms, Leukemia, Lymphoma, Neoplasms, Wilms Tumor, Neuroblastoma, Sarcoma, Hematologic Neoplasms

NCT01415765 2019-12-17

MLN4924 Compared With MLN4924 Plus Chemotherapy for Large B-cell Lymphoma

Phase 1/2 Withdrawn

Acromesomelic dysplasia, Maroteaux type, Lymphoma, Lymphoma, Large B-Cell, Diffuse, Dendritic Cell Sarcoma, Interdigitating

NCT01355445 2019-09-18

VIT-0910

120 enrolled

Rhabdomyosarcoma

NCT00061893 2019-02-15

Vinblastine, Celecoxib, and Combination Chemotherapy in Treating Patients With Newly-Diagnosed Metastatic Ewing's Sarcoma Family of Tumors

38 enrolled 10 charts

Sarcoma, Neuroectodermal Tumors, Primitive, Peripheral

NCT00038207 2018-10-31

Liposomal Vincristine for Pediatric and Adolescent Patients With Relapsed Malignancies

GenitourinaryLymphoidOther hematologic neoplasmSarcoma

29 enrolled

Bone Neoplasms, Leukemia, Lymphoma, Wilms Tumor, Sarcoma, Osteosarcoma

NCT00662233 2018-10-09

Combination Chemotherapy in Treating Patients With Sarcoma

Phase EARLY_PHASE1 Completed

28 enrolled

GynecologicSarcoma

Ovarian Neoplasms, Sarcoma, Desmoplastic Small Round Cell Tumor

NCT00960063 2018-08-27

A Study of Robatumumab (SCH 717454, MK-7454) in Combination With Different Treatment Regimens in Pediatric Participants With Advanced Solid Tumors (P05883, MK-7454-006)

Phase 1 Terminated

4 enrolled 8 charts

CNSGenitourinarySarcoma

Bone Neoplasms, Carcinoma, Renal Cell, Neoplasms, Neuroblastoma

NCT00983944 2017-11-30

Rituximab and Combination Chemotherapy With or Without Bleomycin Sulfate in Treating Patients With Primary Mediastinal Large B-Cell Lymphoma

Phase 2 Withdrawn

Lymphoma, Lymphoma, Large B-Cell, Diffuse, Dendritic Cell Sarcoma, Interdigitating

NCT01313884 2017-11-24

Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings Sarcoma

Phase 2 Terminated

3 enrolled 7 charts

Bone Neoplasms, Sarcoma, Ewing

NCT01055314 2017-08-29

Temozolomide, Cixutumumab, and Combination Chemotherapy in Treating Patients With Metastatic Rhabdomyosarcoma

175 enrolled 13 charts

Rhabdomyosarcoma, Sarcoma

NCT00043979 2017-05-31

Stem Cell Transplantation in Patients With High-Risk and Recurrent Pediatric Sarcomas

60 enrolled 31 charts

Rhabdomyosarcoma, Sarcoma, Sarcoma, Ewing, Desmoplastic Small Round Cell Tumor

NCT01490060 2016-04-11

Fosaprepitant in Patients Receiving Ifosfamide-based Regimen

Phase NA Completed

47 enrolled 6 charts