Announcements Trials
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Phase

Phase 2 2Phase EARLY_PHASE1 1Phase 1 1

Status

Terminated 2Unknown 1Completed 1Approved for marketing 1Active not recruiting 1

Sponsor Class

OTHER 6

Study Type

Interventional 4Observational 1Expanded_access 1

Sponsor

Cancer Type

Sarcoma 6Lymphoid 6Other hematologic neoplasm 5Other 2Genitourinary 1

Conditions

Osteosarcoma 6Renal Insufficiency 2Lymphoma 2Leukemia 2Water Intoxication 1Neoplasms 1Mucositis 1Hematologic Neoplasms 1Drug-Related Side Effects and Adverse Reactions 1Acute Kidney Injury 1

Interventions

Radiotherapy 220Doxorubicin 210Cyclophosphamide 210Temozolomide 182Ifosfamide 121Filgrastim 111Imatinib Mesylate 104Etoposide 101Vincristine 92Gemcitabine 89Bevacizumab 83Magnetic Resonance Spectroscopy 80Irinotecan 79pembrolizumab 75Radiation 69Carboplatin 65Methotrexate 62pazopanib 61Nivolumab 58Cisplatin 58fludarabine phosphate 57Peripheral Blood Stem Cell Transplantation 57Surgical Procedures, Operative 56Specimen Handling 56Trabectedin 52Docetaxel 50Biopsy 50Busulfan 49Melphalan 46Paclitaxel 44

Date Range

30 days90 days1 yearAll

Options

Has results Has announcements

Clinical Trials

6 trials
RecentStart dateEnrollment
glucarpidase × Sarcoma × Clear all
NCT03960177 2026-01-07

Glucarpidase After High-Dose Methotrexate in Patients With Osteosarcoma

OHSU Knight Cancer Institute

Phase EARLY_PHASE1 Active not recruiting
12 enrolled
Sarcoma

Osteosarcoma

NCT05899751 2024-05-10

Retrospective Registry Study of Patients With Cancer Treated With High-dose Methotrexate

BTG International Inc.

Unknown
1,000 enrolled
GenitourinaryOther hematologic neoplasmSarcoma

Osteosarcoma, Water Intoxication, Hematologic Neoplasms, Acute Kidney Injury, Drug-Related Side Effects and Adverse Reactions

NCT00634504 2022-06-06

LVPK

BTG International Inc.

Phase 1 Completed
20 enrolled 9 charts
LymphoidOther hematologic neoplasmSarcoma

Leukemia, Lymphoma, Osteosarcoma, Renal Insufficiency

NCT02022358 2015-06-04

Will Glucarpidase After Methotrexate Treatment for Bone Sarcoma Lead to Fewer Side Effects and Reduce Chemotherapy Delays?

University College, London

Phase 2 Terminated
34 enrolled
OtherSarcoma

Osteosarcoma, Mucositis

NCT00634322 2014-09-15

High Dose Methotrexate With Leucovorin Rescue With or Without Glucarpidase in Osteosarcoma

BTG International Inc.

Phase 2 Terminated
7 enrolled 7 charts
Sarcoma

Osteosarcoma

NCT00481559 2014-01-17

Treatment Protocol of Voraxaze for Patients Experiencing or at Risk of Methotrexate Toxicity

BTG International Inc.

Approved for marketing
LymphoidOther hematologic neoplasmSarcoma

Leukemia, Lymphoma, Neoplasms, Osteosarcoma, Renal Insufficiency

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